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Ultrasound Localization Microscopy (ULM) has presented great potential in functional imaging, benefiting from its ability to reconstruct deep microvasculature. However, the hemodynamic reconstruction is compromised by sparsity in the ULM…

Image and Video Processing · Electrical Eng. & Systems 2026-05-27 Jipeng Yan , Oscar Bates , Jingwen Zhu , Qingyuan Tan , Biao Huang , John Goodwin , Andriy S. Kozlov , Chris Dunsby , Meng-Xing Tang

We show that structural information can be extracted from single molecule localization microscopy (SMLM) data. More precisely, we reinterpret SMLM data as the measures of a phaseless optical diffraction tomography system for which the…

Signal Processing · Electrical Eng. & Systems 2023-07-19 Thanh-An Pham , Emmanuel Soubies , Ferréol Soulez , Michael Unser

Skull-induced aberrations remain a major drawback of transcranial ultrasound localization microscopy (ULM), degrading sensitivity and spatial accuracy through microbubble mislocalization, false detections, and imaging artifacts, such as…

Biomedical imaging is unequivocally dependent on the ability to reconstruct interpretable and high-quality images from acquired sensor data. This reconstruction process is pivotal across many applications, spanning from magnetic resonance…

Signal Processing · Electrical Eng. & Systems 2019-09-24 Ben Luijten , Regev Cohen , Frederik J. de Bruijn , Harold A. W. Schmeitz , Massimo Mischi , Yonina C. Eldar , Ruud J. G. van Sloun

Mapping blood microflows of the whole brain is crucial for early diagnosis of cerebral diseases. Ultrasound localization microscopy (ULM) was recently applied to map and quantify blood microflows in 2D in the brain of adult patients down to…

Medical Physics · Physics 2023-04-12 Hugues Favre , Mathieu Pernot , Mickael Tanter , Clément Papadacci

In portable, three dimensional, and ultra-fast ultrasound imaging systems, there is an increasing demand for the reconstruction of high quality images from a limited number of radio-frequency (RF) measurements due to receiver (Rx) or…

Computer Vision and Pattern Recognition · Computer Science 2018-08-08 Yeo Hun Yoon , Shujaat Khan , Jaeyoung Huh , Jong Chul Ye

Ultrasound Localization Microscopy (ULM) relies on the injection of microbubbles (MBs) to obtain highly resolved density maps of blood circulation in vivo, with a resolution that can reach 10 {\mu}m ~ {\lambda}/10 in the rodent brain.…

Automatic learning algorithms for improving the image quality of diagnostic B-mode ultrasound (US) images have been gaining popularity in the recent past. In this work, a novel convolutional neural network (CNN) is trained using time of…

Signal Processing · Electrical Eng. & Systems 2021-08-18 Roshan P Mathews , Mahesh Raveendranatha Panicker

Super-resolution ultrasound (SR-US) is a powerful imaging technique for capturing microvasculature and blood flow at high spatial resolution. However, accurate microbubble (MB) localization remains a key challenge, as errors in localization…

Image and Video Processing · Electrical Eng. & Systems 2025-01-06 Sepideh K. Gharamaleki , Brandon Helfield , Hassan Rivaz

The diffraction of light imposes a fundamental limit on the resolution of light microscopes. This limit can be circumvented by creating and exploiting independent behaviors of the sample at length scales below the diffraction limit. In…

Biological Physics · Physics 2024-06-19 Mohamadreza Fazel , Michael J. Wester

Transient brain-wide neuroimaging on a microscopic scale is pivotal for brain research, yet current modalities face challenges in meeting such spatiotemporal requirements. Functional ultrasound (fUS) enables transient neurovascular imaging…

Medical Physics · Physics 2025-12-09 Yang Cai , Shaoyuan Yan , Long Xu , Yanfeng Zhu , Bo Li , Kailiang Xu

In the recent past, there have been several efforts in accelerating computationally heavy beamforming algorithms such as minimum variance distortionless response (MVDR) beamforming to achieve real-time performance comparable to the popular…

Signal Processing · Electrical Eng. & Systems 2021-10-22 Sairoop Bodepudi , A N Madhavanunni , Mahesh Raveendranatha Panicker

We propose a novel deep-learning framework for super-resolution ultrasound images and videos in terms of spatial resolution and line reconstruction. We up-sample the acquired low-resolution image through a vision-based interpolation method;…

Computer Vision and Pattern Recognition · Computer Science 2023-05-03 Simone Cammarasana , Paolo Nicolardi , Giuseppe Patanè

For beamforming ultrasound (US) signals, typically a spatially constant speed-of-sound (SoS) is assumed to calculate delays. As SoS in tissue may vary relatively largely, this approximation may cause wavefront aberrations, thus degrading…

Image and Video Processing · Electrical Eng. & Systems 2019-12-12 Richard Rau , Dieter Schweizer , Valery Vishnevskiy , Orcun Goksel

Delay-and-sum (DAS) is the most widespread digital beamformer in high-frame-rate ultrasound imaging. Its implementation is simple and compatible with real-time applications. In this viewpoint article, we describe the fundamentals of DAS…

Signal Processing · Electrical Eng. & Systems 2021-12-17 Vincent Perrot , Maxime Polichetti , François Varray , Damien Garcia

Ultrafast ultrasound imaging insonifies a medium with one or a combination of a few plane waves at different beam-steered angles instead of many focused waves. It can achieve much higher frame rates, but often at the cost of reduced image…

Image and Video Processing · Electrical Eng. & Systems 2024-04-23 Ryan A. L. Schoop , Gijs Hendriks , Tristan van Leeuwen , Chris L. de Korte , Felix Lucka

Super-resolution ultrasound imaging through microbubble (MB) localisation and tracking, also known as ultrasound localisation microscopy, allows non-invasive sub-diffraction resolution imaging of microvasculature in animals and humans. The…

Image and Video Processing · Electrical Eng. & Systems 2025-05-23 Su Yan , Clotilde Vié , Marcelo Lerendegui , Herman Verinaz-Jadan , Jipeng Yan , Martina Tashkova , James Burn , Bingxue Wang , Gary Frost , Kevin G. Murphy , Meng-Xing Tang

Ultrasound image reconstruction can be approximately cast as a linear inverse problem that has traditionally been solved with penalized optimization using the $l_1$ or $l_2$ norm, or wavelet-based terms. However, such regularization…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Yuxin Zhang , Clément Huneau , Jérôme Idier , Diana Mateus

Guided ultrasonic wave localization uses spatially distributed multistatic sensor arrays and generalized beamforming strategies to detect and locate damage across a structure. The propagation channel is often very complex. Methods can…

Signal Processing · Electrical Eng. & Systems 2024-10-30 Ishan D. Khurjekar , Joel B. Harley

In many ultrasonic imaging systems, data acquisition and image formation are performed on separate computing devices. Data transmission is becoming a bottleneck, thus, efficient data compression is essential. Compression rates can be…

Image and Video Processing · Electrical Eng. & Systems 2021-09-02 Georgios Pilikos , Lars Horchens , Kees Joost Batenburg , Tristan van Leeuwen , Felix Lucka