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Recent years have witnessed a substantial increase in the use of deep learning to solve various natural language processing (NLP) problems. Early deep learning models were constrained by their sequential or unidirectional nature, such that…

Information Retrieval · Computer Science 2024-03-05 Jiajia Wang , Jimmy X. Huang , Xinhui Tu , Junmei Wang , Angela J. Huang , Md Tahmid Rahman Laskar , Amran Bhuiyan

Encoder-only transformer models such as BERT offer a great performance-size tradeoff for retrieval and classification tasks with respect to larger decoder-only models. Despite being the workhorse of numerous production pipelines, there have…

DNA language models have advanced genomics, but their downstream performance varies widely due to differences in tokenization, pretraining data, and architecture. We argue that a major bottleneck lies in tokenizing sparse and unevenly…

Genomics · Quantitative Biology 2025-12-23 Xiaoxiao Zhou , Zihan Wang , Jingbo Shang , Yang E. Li

Tabular data is prevalent across diverse domains in machine learning. With the rapid progress of deep tabular prediction methods, especially pretrained (foundation) models, there is a growing need to evaluate these methods systematically…

Machine Learning · Computer Science 2025-11-10 Han-Jia Ye , Si-Yang Liu , Hao-Run Cai , Qi-Le Zhou , De-Chuan Zhan

DNA Language Models, such as GROVER, DNABERT2 and the Nucleotide Transformer, operate on DNA sequences that inherently contain sequencing errors, mutations, and laboratory-induced noise, which may significantly impact model performance.…

Computation and Language · Computer Science 2025-03-04 Hyunwoo Yoo , Haebin Shin , Kaidi Xu , Gail Rosen

RNA is a vital biomolecule with numerous roles and functions within cells, and interest in targeting it for therapeutic purposes has grown significantly in recent years. However, fully understanding and predicting RNA behavior, particularly…

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

What can pre-trained multilingual sequence-to-sequence models like mBART contribute to translating low-resource languages? We conduct a thorough empirical experiment in 10 languages to ascertain this, considering five factors: (1) the…

This paper presents the Ensemble Nucleotide Byte-level Encoder-Decoder (ENBED) foundation model, analyzing DNA sequences at byte-level precision with an encoder-decoder Transformer architecture. ENBED uses a sub-quadratic implementation of…

Machine Learning · Computer Science 2024-08-26 Aditya Malusare , Harish Kothandaraman , Dipesh Tamboli , Nadia A. Lanman , Vaneet Aggarwal

Visual as well as genetic biometrics are routinely employed to identify species and individuals in biological applications. However, no attempts have been made in this domain to computationally enhance visual classification of rare classes…

Computer Vision and Pattern Recognition · Computer Science 2023-09-14 Tayfun Karaderi , Tilo Burghardt , Raphael Morard , Daniela Schmidt

Over the past few decades, Artificial Intelligence(AI) has progressed from the initial machine learning stage to the deep learning stage, and now to the stage of foundational models. Foundational models have the characteristics of…

Computation and Language · Computer Science 2024-11-28 Lewen Yang , Xuanyu Zhou , Juao Fan , Xinyi Xie , Shengxin Zhu

Processing information locked within clinical health records is a challenging task that remains an active area of research in biomedical NLP. In this work, we evaluate a broad set of machine learning techniques ranging from simple RNNs to…

Data-efficient image classification is a challenging task that aims to solve image classification using small training data. Neural network-based deep learning methods are effective for image classification, but they typically require…

Neural and Evolutionary Computing · Computer Science 2022-12-05 Ying Bi , Bing Xue , Mengjie Zhang

With the success of large-scale pre-training in language tasks, there is an increasing trend of applying it to the domain of life sciences. In particular, pre-training methods based on DNA sequences have received increasing attention…

Artificial Intelligence · Computer Science 2024-09-10 Chaoqi Liang , Lifeng Qiao , Peng Ye , Nanqing Dong , Jianle Sun , Weiqiang Bai , Yuchen Ren , Xinzhu Ma , Hongliang Yan , Chunfeng Song , Wanli Ouyang , Wangmeng Zuo

The genome sequence contains the blueprint for governing cellular processes. While the availability of genomes has vastly increased over the last decades, experimental annotation of the various functional, non-coding and regulatory elements…

Genomics · Quantitative Biology 2024-04-10 Frederikke Isa Marin , Felix Teufel , Marc Horlacher , Dennis Madsen , Dennis Pultz , Ole Winther , Wouter Boomsma

Code representation learning, which aims to encode the semantics of source code into distributed vectors, plays an important role in recent deep-learning-based models for code intelligence. Recently, many pre-trained language models for…

Computation and Language · Computer Science 2021-09-10 Xin Wang , Yasheng Wang , Fei Mi , Pingyi Zhou , Yao Wan , Xiao Liu , Li Li , Hao Wu , Jin Liu , Xin Jiang

Identifying phenotypes plays an important role in furthering our understanding of disease biology through practical applications within healthcare and the life sciences. The challenge of dealing with the complexities and noise within…

Applications · Statistics 2023-04-28 Andre Vauvelle , Hamish Tomlinson , Aaron Sim , Spiros Denaxas

The use of modern Natural Language Processing (NLP) techniques has shown to be beneficial for software engineering tasks, such as vulnerability detection and type inference. However, training deep NLP models requires significant…

Software Engineering · Computer Science 2023-09-12 Anastasiia Grishina , Max Hort , Leon Moonen

Efficient text embedding is crucial for large-scale natural language processing (NLP) applications, where storage and computational efficiency are key concerns. In this paper, we explore how using binary representations (barcodes) instead…

Computation and Language · Computer Science 2025-07-24 Soumen Sinha , Shahryar Rahnamayan , Azam Asilian Bidgoli

Ground beetles are a highly sensitive and speciose biological indicator, making them vital for monitoring biodiversity. However, they are currently an underutilized resource due to the manual effort required by taxonomic experts to perform…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 S M Rayeed , Alyson East , Samuel Stevens , Sydne Record , Charles V Stewart