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Modeling sequence evolution on phylogenetic trees is a useful technique in computational biology. Especially powerful are models which take account of the heterogeneous nature of sequence evolution according to the "grammar" of the encoded…

Quantitative Methods · Quantitative Biology 2015-06-04 Oscar Westesson , Ian Holmes

Precision and reliability of barcode-based biodiversity assessment can be affected at several steps during acquisition and analysis of the data. Identification of barcodes is one of the crucial steps in the process and can be accomplished…

Populations and Evolution · Quantitative Biology 2017-04-19 Oleksandr Holovachov , Quiterie Haenel , Sarah J. Bourlat , Ulf Jondelius

Large-scale language model pretraining is a very successful form of self-supervised learning in natural language processing, but it is increasingly expensive to perform as the models and pretraining corpora have become larger over time. We…

Computation and Language · Computer Science 2023-06-07 Haoxin Li , Phillip Keung , Daniel Cheng , Jungo Kasai , Noah A. Smith

In recent years, with the growing amount of biomedical documents, coupled with advancement in natural language processing algorithms, the research on biomedical named entity recognition (BioNER) has increased exponentially. However, BioNER…

Computation and Language · Computer Science 2020-09-22 Usman Naseem , Matloob Khushi , Vinay Reddy , Sakthivel Rajendran , Imran Razzak , Jinman Kim

In the genome biology research, regulatory genome modeling is an important topic for many regulatory downstream tasks, such as promoter classification, transaction factor binding sites prediction. The core problem is to model how regulatory…

Genomics · Quantitative Biology 2021-11-04 Shentong Mo , Xi Fu , Chenyang Hong , Yizhen Chen , Yuxuan Zheng , Xiangru Tang , Zhiqiang Shen , Eric P Xing , Yanyan Lan

Encoder-based transformer models are central to biomedical and clinical Natural Language Processing (NLP), as their bidirectional self-attention makes them well-suited for efficiently extracting structured information from unstructured text…

Metagenomic disease prediction commonly relies on species abundance tables derived from large, incomplete reference catalogs, constraining resolution and discarding valuable information contained in DNA reads. To overcome these limitations,…

Genomics · Quantitative Biology 2026-01-08 Gaspar Roy , Eugeni Belda , Baptiste Hennecart , Yann Chevaleyre , Edi Prifti , Jean-Daniel Zucker

The brain can only be fully understood through the lens of the behavior it generates -- a guiding principle in modern neuroscience research that nevertheless presents significant technical challenges. Many studies capture behavior with…

Neurons and Cognition · Quantitative Biology 2026-03-02 Yanchen Wang , Han Yu , Ari Blau , Yizi Zhang , The International Brain Laboratory , Liam Paninski , Cole Hurwitz , Matt Whiteway

Biomedical text mining is becoming increasingly important as the number of biomedical documents rapidly grows. With the progress in natural language processing (NLP), extracting valuable information from biomedical literature has gained…

Computation and Language · Computer Science 2019-10-21 Jinhyuk Lee , Wonjin Yoon , Sungdong Kim , Donghyeon Kim , Sunkyu Kim , Chan Ho So , Jaewoo Kang

Pre-trained models of source code have recently been successfully applied to a wide variety of Software Engineering tasks; they have also seen some practical adoption in practice, e.g. for code completion. Yet, we still know very little…

Software Engineering · Computer Science 2023-12-11 Anjan Karmakar , Romain Robbes

DNA sequence encoding is fundamental to gene function prediction, protein synthesis, and diverse downstream biological tasks. Despite the substantial progress achieved by large-scale DNA sequence pretraining, existing studies have…

Machine Learning · Computer Science 2026-04-21 Zhijiang Tang , Jiaxin Qi , Yan Cui , Jinli Ou , Yuhua Zheng , Jianqiang Huang

The Transformer architecture and transfer learning have marked a quantum leap in natural language processing, improving the state of the art across a range of text-based tasks. This paper examines how these advancements can be applied to…

Software Engineering · Computer Science 2022-08-29 Pasquale Salza , Christoph Schwizer , Jian Gu , Harald C. Gall

As part of an ongoing worldwide effort to comprehend and monitor insect biodiversity, this paper presents the BIOSCAN-5M Insect dataset to the machine learning community and establish several benchmark tasks. BIOSCAN-5M is a comprehensive…

Purpose: This study aimed to enhance protein sequence classification using natural language processing (NLP) techniques while addressing the impact of sequence similarity on model performance. We compared various machine learning and deep…

Quantitative Methods · Quantitative Biology 2025-05-26 Huma Perveen , Julie Weeds

Bioacoustics, the study of sounds produced by living organisms, plays a vital role in conservation, biodiversity monitoring, and behavioral studies. Many tasks in this field, such as species, individual, and behavior classification and…

Machine- and deep-learning approaches for biological sequences depend critically on transforming raw DNA, RNA, and protein FASTA files into informative numerical representations. However, this process is often fragmented across multiple…

Genomics · Quantitative Biology 2025-12-01 Hamid Ismail , Marwan Bikdash

Predicting gene function from its DNA sequence is a fundamental challenge in biology. Many deep learning models have been proposed to embed DNA sequences and predict their enzymatic function, leveraging information in public databases…

Motivation: Biomedical named-entity normalization involves connecting biomedical entities with distinct database identifiers in order to facilitate data integration across various fields of biology. Existing systems for biomedical named…

Computation and Language · Computer Science 2023-10-24 Zainab Awan , Tim Kahlke , Peter Ralph , Paul Kennedy

Although the prediction of dialects is an important language processing task, with a wide range of applications, existing work is largely limited to coarse-grained varieties. Inspired by geolocation research, we propose the novel task of…

Computation and Language · Computer Science 2020-12-08 Muhammad Abdul-Mageed , Chiyu Zhang , AbdelRahim Elmadany , Lyle Ungar

Specialised transformers-based models (such as BioBERT and BioMegatron) are adapted for the biomedical domain based on publicly available biomedical corpora. As such, they have the potential to encode large-scale biological knowledge. We…

Computation and Language · Computer Science 2022-12-22 Oskar Wysocki , Zili Zhou , Paul O'Regan , Deborah Ferreira , Magdalena Wysocka , Dónal Landers , André Freitas