Related papers: The serotonergic psychedelic N,N-dipropyltryptamin…
Neuroplasticity, the ability of the nervous system to adapt throughout an organism's lifespan, offers potential as both a biomarker and treatment target for neuropsychiatric conditions. Psychedelics, a burgeoning category of drugs, are…
Anesthetic agents are known to induce a range of alterations in cortical electrophysiological activity, such as the rise of signature patterns, changes in statistical properties, and altered dynamic behavior of neural records. Plenty of…
Reward processing and derangements thereof, such as drug addiction, involve the coordinated activity of many brain areas. Prior work has identified many behavioral, molecular biological and single neuron changes throughout the…
Humans have employed an incredible variety of plant-derived substances over the millennia in order to alter consciousness and perception. Among the innumerable narcotics, analgesics, 'ordeal' drugs, and other psychoactive substances…
Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We…
Synaptic connections are known to change dynamically. High-frequency presynaptic inputs induce decrease of synaptic weights. This process is known as short-term synaptic depression. The synaptic depression controls a gain for presynaptic…
Our brain is a complex information processing network in which the nervous system receives information from the environment to quickly react to incoming events or learns from experience to sharp our memory. In the nervous system, the brain…
Chaos provides many interesting properties that can be used to achieve computational tasks. Such properties are sensitivity to initial conditions, space filling, control and synchronization. Chaotic neural models have been devised to…
Background: Psychedelic drugs facilitate profound changes in consciousness and have potential to provide insights into the nature of human mental processes and their relation to brain physiology. Yet published scientific literature reflects…
We theoretically investigate long-term potentiation (LTP) in the hippocampus using a simple model of a neuron stimulated by three different time-structured input signals (regular, Markov, and chaotic). The synaptic efficacy change is…
Neurons in a micro-circuit connected by chemical synapses can have their connectivity affected by the prior activity of the cells. The number of synapses available for releasing neurotransmitter can be decreased by repetitive activation…
Psychedelics have shown potential in treating a range of mental health conditions, yet far less is known about their impact on creativity. This study examined three components of creativity-divergent thinking, cognitive reflection, and…
Neural synchrony in the brain at rest is usually variable and intermittent, thus intervals of predominantly synchronized activity are interrupted by intervals of desynchronized activity. Prior studies suggested that this temporal structure…
The discrete stochastic dynamics of a random walker in the presence of resetting and memory is analyzed. Resetting and memory effects may compete for certain parameter regime and lead to significant changes in the long time dynamics of the…
Experimental data have revealed that neuronal connection efficacy exhibits two forms of short-term plasticity, namely, short-term depression (STD) and short-term facilitation (STF). They have time constants residing between fast neural…
Short-term changes in efficacy have been postulated to enhance the ability of synapses to transmit information between neurons, and within neuronal networks. Even at the level of connections between single neurons, direct confirmation of…
The glutamatergic modulator ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant major depressive disorder (TRD). Although its mechanisms of action are not fully understood, changes in cortical…
Recently Segev et al. (Phys. Rev. E 64,2001, Phys.Rev.Let. 88, 2002) made long-term observations of spontaneous activity of in-vitro cortical networks, which differ from predictions of current models in many features. In this paper we…
Abstract Objective In Genetic Absence Epilepsy Rats From Strasbourg ( GAERS s), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are…
A massively recurrent neural network responds on one side to input stimuli and is autonomously active, on the other side, in the absence of sensory inputs. Stimuli and information processing depends crucially on the qualia of the…