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Domain generalization in computational histopathology is hindered by heterogeneity in whole slide images (WSIs), caused by variations in tissue preparation, staining, and imaging conditions across institutions. Unlike machine learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Hikmat Khan , Syed Farhan Alam Zaidi , Pir Masoom Shah , Kiruthika Balakrishnan , Rabia Khan , Muhammad Waqas , Jia Wu

Modern deep neural networks struggle to transfer knowledge and generalize across diverse domains when deployed to real-world applications. Currently, domain generalization (DG) is introduced to learn a universal representation from multiple…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Yijun Yang , Shujun Wang , Lei Zhu , Lequan Yu

We present a clustering-based explainability technique for digital pathology models based on convolutional neural networks. Unlike commonly used methods based on saliency maps, such as occlusion, GradCAM, or relevance propagation, which…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Adam Bajger , Jan Obdržálek , Vojtěch Kůr , Rudolf Nenutil , Petr Holub , Vít Musil , Tomáš Brázdil

Computer-Aided Diagnosis and Treatment of Tumors is a hot topic of deep learning in recent years, which constitutes a series of medical tasks, such as detection of tumor markers, the outline of tumor leisures, subtypes and stages of tumors,…

Image and Video Processing · Electrical Eng. & Systems 2020-11-03 Dan Zhao , Guizhi Xu , Zhenghua XU , Thomas Lukasiewicz , Minmin Xue , Zhigang Fu

Domain Generalization (DG) aims to resolve distribution shifts between source and target domains, and current DG methods are default to the setting that data from source and target domains share identical categories. Nevertheless, there…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Zining Chen , Weiqiu Wang , Zhicheng Zhao , Fei Su , Aidong Men , Hongying Meng

With the advent of digital pathology and microscopic systems that can scan and save whole slide histological images automatically, there is a growing trend to use computerized methods to analyze acquired images. Among different…

Image and Video Processing · Electrical Eng. & Systems 2024-01-10 Amirreza Mahbod , Georg Dorffner , Isabella Ellinger , Ramona Woitek , Sepideh Hatamikia

As a recent noticeable topic, domain generalization (DG) aims to first learn a generic model on multiple source domains and then directly generalize to an arbitrary unseen target domain without any additional adaption. In previous DG…

Computer Vision and Pattern Recognition · Computer Science 2022-02-17 Yue Wang , Lei Qi , Yinghuan Shi , Yang Gao

Computer-aided diagnosis (CAD) based on histopathological imaging has progressed rapidly in recent years with the rise of machine learning based methodologies. Traditional approaches consist of training a classification model using features…

Computer Vision and Pattern Recognition · Computer Science 2019-03-29 Junaid Malik , Serkan Kiranyaz , Suchitra Kunhoth , Turker Ince , Somaya Al-Maadeed , Ridha Hamila , Moncef Gabbouj

The examination of histopathology images is considered to be the gold standard for the diagnosis and stratification of cancer patients. A key challenge in the analysis of such images is their size, which can run into the gigapixels and can…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Joseph Boyd , Mykola Liashuha , Eric Deutsch , Nikos Paragios , Stergios Christodoulidis , Maria Vakalopoulou

Deep learning has been increasingly incorporated into various computational pathology applications to improve its efficiency, accuracy, and robustness. Although successful, most previous approaches for image classification have crucial…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Anh Tien Nguyen , Jin Tae Kwak

The domain generalization problem has been widely investigated in deep learning for non-contrast imaging over the last years, but it received limited attention for contrast-enhanced imaging. However, there are marked differences in contrast…

The success of deep learning models deployed in the real world depends critically on their ability to generalize well across diverse data domains. Here, we address a fundamental challenge with selective classification during automated…

Computer Vision and Pattern Recognition · Computer Science 2023-11-29 Anuj Srivastava , Karm Patel , Pradeep Shenoy , Devarajan Sridharan

Domain generalization (DG), aiming at models able to work on multiple unseen domains, is a must-have characteristic of general artificial intelligence. DG based on single source domain training data is more challenging due to the lack of…

Computer Vision and Pattern Recognition · Computer Science 2023-04-17 Qingyue Yang , Hongjing Niu , Pengfei Xia , Wei Zhang , Bin Li

Domain Generalization (DG) aims to learn representations that remain robust under out-of-distribution (OOD) shifts and generalize effectively to unseen target domains. While recent invariant learning strategies and architectural advances…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Yu-Hsi Chen , Abd-Krim Seghouane

Domain generalization (DG) is a fundamental yet very challenging research topic in machine learning. The existing arts mainly focus on learning domain-invariant features with limited source domains in a static model. Unfortunately, there is…

Machine Learning · Computer Science 2022-05-30 Zhishu Sun , Zhifeng Shen , Luojun Lin , Yuanlong Yu , Zhifeng Yang , Shicai Yang , Weijie Chen

Standard supervised learning setting assumes that training data and test data come from the same distribution (domain). Domain generalization (DG) methods try to learn a model that when trained on data from multiple domains, would…

Computer Vision and Pattern Recognition · Computer Science 2020-08-18 Udit Maniyar , Joseph K J , Aniket Anand Deshmukh , Urun Dogan , Vineeth N Balasubramanian

Cervical cancer remains a major malignancy, necessitating extensive and complex histopathological assessments and comprehensive support tools. Although deep learning shows promise, these models still lack accuracy and generalizability.…

Computational pathology is part of precision oncology medicine. The integration of high-throughput data including genomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics into clinical practice improves cancer treatment…

Image and Video Processing · Electrical Eng. & Systems 2022-06-07 Liangrui Pan , Zhichao Feng , Shaoliang Peng

Machine learning models that can generalize to unseen domains are essential when applied in real-world scenarios involving strong domain shifts. We address the challenging domain generalization (DG) problem, where a model trained on a set…

Machine Learning · Computer Science 2022-10-04 Ahmed Frikha , Denis Krompaß , Volker Tresp

Domain Generalization (DG) studies the capability of a deep learning model to generalize to out-of-training distributions. In the last decade, literature has been massively filled with training methodologies that claim to obtain more…

Computer Vision and Pattern Recognition · Computer Science 2023-05-10 Simone Angarano , Mauro Martini , Francesco Salvetti , Vittorio Mazzia , Marcello Chiaberge