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Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant…

The field of self-supervised learning (SSL) for 3D medical images lacks consistency and standardization. While many methods have been developed, it is impossible to identify the current state-of-the-art, due to i) varying and small…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Tassilo Wald , Constantin Ulrich , Jonathan Suprijadi , Sebastian Ziegler , Michal Nohel , Robin Peretzke , Gregor Köhler , Klaus H. Maier-Hein

The field of Machine Learning, a subset of Artificial Intelligence, has led to remarkable advancements in many areas, including medicine. Machine Learning algorithms require large datasets to train computer models successfully. Although…

Image and Video Processing · Electrical Eng. & Systems 2019-12-30 Andrew A. Borkowski , Marilyn M. Bui , L. Brannon Thomas , Catherine P. Wilson , Lauren A. DeLand , Stephen M. Mastorides

The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Alexander Weers , Alexander H. Berger , Laurin Lux , Peter Schüffler , Daniel Rueckert , Johannes C. Paetzold

Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin \& eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher…

Data-driven methods have shown tremendous progress in medical image analysis. In this context, deep learning-based supervised methods are widely popular. However, they require a large amount of training data and face issues in…

Computer Vision and Pattern Recognition · Computer Science 2023-06-02 Ziang Xu , Jens Rittscher , Sharib Ali

In the segmentation of remotely sensed images, deep learning models are typically pre-trained using large image databases like ImageNet before fine-tuned on domain-specific datasets. However, the performance of these fine-tuned models is…

Computer Vision and Pattern Recognition · Computer Science 2026-05-01 Yuan Fang , Yuanzhi Cai , Jagannath Aryal , Qinfeng Zhu , Hong Huang , Cheng Zhang , Lei Fan

Recent advances in whole slide imaging (WSI) technology have led to the development of a myriad of computer vision and artificial intelligence (AI) based diagnostic, prognostic, and predictive algorithms. Computational Pathology (CPath)…

The incorporation of physical information in machine learning frameworks is transforming medical image analysis (MIA). By integrating fundamental knowledge and governing physical laws, these models achieve enhanced robustness and…

Image and Video Processing · Electrical Eng. & Systems 2024-08-05 Chayan Banerjee , Kien Nguyen , Olivier Salvado , Truyen Tran , Clinton Fookes

Medical image segmentation is a critical yet challenging task, primarily due to the difficulty of obtaining extensive datasets of high-quality, expert-annotated images. Contrastive learning presents a potential but still problematic…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Shuang Zeng , Lei Zhu , Xinliang Zhang , Hangzhou He , Yanye Lu

Pathology image analysis plays a pivotal role in medical diagnosis, with deep learning techniques significantly advancing diagnostic accuracy and research. While numerous studies have been conducted to address specific pathological tasks,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Dankai Liao , Sicheng Chen , Nuwa Xi , Qiaochu Xue , Jieyu Li , Lingxuan Hou , Zeyu Liu , Chang Han Low , Yufeng Wu , Yiling Liu , Yanqin Jiang , Dandan Li , Shangqing Lyu

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Whole slide imaging is routinely adopted for carcinoma diagnosis and prognosis. Abundant experience is required for pathologists to achieve accurate and reliable diagnostic results of whole slide images (WSI). The huge size and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Pingyi Chen , Chenglu Zhu , Sunyi Zheng , Honglin Li , Lin Yang

Computational cytology is a critical, rapid-developing, yet challenging topic in the field of medical image computing which analyzes the digitized cytology image by computer-aided technologies for cancer screening. Recently, an increasing…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Hao Jiang , Yanning Zhou , Yi Lin , Ronald CK Chan , Jiang Liu , Hao Chen

Histopathological images are widely used for the analysis of diseased (tumor) tissues and patient treatment selection. While the majority of microscopy image processing was previously done manually by pathologists, recent advances in…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Andrey Ignatov , Josephine Yates , Valentina Boeva

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

Existing Vision-Language Models (VLMs) are predominantly trained on web-scraped, noisy image-text data, exhibiting limited exposure to the specialized domain of RS. This deficiency results in poor performance on RS-specific tasks, as…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Angelos Zavras , Dimitrios Michail , Xiao Xiang Zhu , Begüm Demir , Ioannis Papoutsis

Task-specific deep learning models in histopathology offer promising opportunities for improving diagnosis, clinical research, and precision medicine. However, development of such models is often limited by availability of high-quality…

Digitized histopathology glass slides, known as Whole Slide Images (WSIs), are often several gigapixels large and contain sensitive metadata information, which makes distributed processing unfeasible. Moreover, artifacts in WSIs may result…

Computational Engineering, Finance, and Science · Computer Science 2023-09-14 Yuandou Wang , Neel Kanwal , Kjersti Engan , Chunming Rong , Zhiming Zhao

In medical image segmentation, limited external validity remains a critical obstacle when models are deployed across unseen datasets, an issue particularly pronounced in the ultrasound image domain. Existing solutions-such as domain…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Christian Schmidt , Heinrich Martin Overhoff