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Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes…

Computer Vision and Pattern Recognition · Computer Science 2022-07-20 Marvin Teichmann , Andre Aichert , Hanibal Bohnenberger , Philipp Ströbel , Tobias Heimann

Precision medicine in the quantitative management of chronic diseases and oncology would be greatly improved if the Computed Tomography (CT) scan of any patient could be segmented, parsed and analyzed in a precise and detailed way. However,…

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

The coronavirus pandemic has been going on since the year 2019, and the trend is still not abating. Therefore, it is particularly important to classify medical CT scans to assist in medical diagnosis. At present, Supervised Deep Learning…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Jiashu Xu , Sergii Stirenko

Deep convolutional neural networks (CNNs) are the current state-of-the-art for digital analysis of histopathological images. The large size of whole-slide microscopy images (WSIs) requires advanced memory handling to read, display and…

Machine Learning · Computer Science 2020-11-13 André Pedersen , Marit Valla , Anna M. Bofin , Javier Pérez de Frutos , Ingerid Reinertsen , Erik Smistad

The segmentation of metastatic bone disease (MBD) in whole-body MRI (WB-MRI) is a challenging problem. Due to varying appearances and anatomical locations of lesions, ambiguous boundaries, and severe class imbalance, obtaining reliable…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Joris Wuts , Jakub Ceranka , Nicolas Michoux , Frédéric Lecouvet , Jef Vandemeulebroucke

Whole Slide Imaging (WSI) is a cornerstone of digital pathology, offering detailed insights critical for diagnosis and research. Yet, the gigapixel size of WSIs imposes significant computational challenges, limiting their practical utility.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Ravi Kant Gupta , Shounak Das , Amit Sethi

Vision Language Models (VLMs) like CLIP have attracted substantial attention in pathology, serving as backbones for applications such as zero-shot image classification and Whole Slide Image (WSI) analysis. Additionally, they can function as…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Yuxuan Sun , Yunlong Zhang , Yixuan Si , Chenglu Zhu , Zhongyi Shui , Kai Zhang , Jingxiong Li , Xingheng Lyu , Tao Lin , Lin Yang

Self-supervised learning (SSL) methods have become a dominant paradigm for creating general purpose models whose capabilities can be transferred to downstream supervised learning tasks. However, most such methods rely on vast amounts of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Lakshay Sharma , Alex Marin

An increasing number of public datasets have shown a marked impact on automated organ segmentation and tumor detection. However, due to the small size and partially labeled problem of each dataset, as well as a limited investigation of…

Image and Video Processing · Electrical Eng. & Systems 2024-06-27 Jie Liu , Yixiao Zhang , Jie-Neng Chen , Junfei Xiao , Yongyi Lu , Bennett A. Landman , Yixuan Yuan , Alan Yuille , Yucheng Tang , Zongwei Zhou

Pre-training general-purpose visual features with convolutional neural networks without relying on annotations is a challenging and important task. Most recent efforts in unsupervised feature learning have focused on either small or highly…

Computer Vision and Pattern Recognition · Computer Science 2019-08-14 Mathilde Caron , Piotr Bojanowski , Julien Mairal , Armand Joulin

The use of self-supervised learning (SSL) to train pathology foundation models has increased substantially in the past few years. Notably, several models trained on large quantities of clinical data have been made publicly available in…

Proteins are essential component of human life and their structures are important for function and mechanism analysis. Recent work has shown the potential of AI-driven methods for protein structure prediction. However, the development of…

Representation learning of pathology whole-slide images (WSIs) has primarily relied on weak supervision with Multiple Instance Learning (MIL). This approach leads to slide representations highly tailored to a specific clinical task.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Tim Lenz , Peter Neidlinger , Marta Ligero , Georg Wölflein , Marko van Treeck , Jakob Nikolas Kather

Based on digital pathology slice scanning technology, artificial intelligence algorithms represented by deep learning have achieved remarkable results in the field of computational pathology. Compared to other medical images, pathology…

Image and Video Processing · Electrical Eng. & Systems 2023-11-17 Hao Quan , Xingyu Li , Weixing Chen , Qun Bai , Mingchen Zou , Ruijie Yang , Tingting Zheng , Ruiqun Qi , Xinghua Gao , Xiaoyu Cui

Deep neural networks are efficient at learning the data distribution if it is sufficiently sampled. However, they can be strongly biased by non-relevant factors implicitly incorporated in the training data. These include operational biases,…

Computer Vision and Pattern Recognition · Computer Science 2022-03-04 Kirill Sirotkin , Pablo Carballeira , Marcos Escudero-Viñolo

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

Whole-slide image visual question answering (WSI-VQA) frames pathology as an extreme-context search problem: to answer a free-form clinical query, a system must first navigate a gigapixel slide under a strict inspection budget to locate…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Chunze Yang , Qidong Liu , Wenjie Zhao , Yue Tang , Jiusong Ge , Di Zhang , Jiashuai Liu , Lei Wu , Junbo Lu , Ni Zhang , Xian Wu , Zeyu Gao , Chen Li

Self-supervised learning (SSL) has become the de facto training paradigm of large models, where pre-training is followed by supervised fine-tuning using domain-specific data and labels. Despite demonstrating comparable performance with…

Machine Learning · Computer Science 2024-06-05 Sofia Yfantidou , Dimitris Spathis , Marios Constantinides , Athena Vakali , Daniele Quercia , Fahim Kawsar

Deep neural networks have introduced significant advancements in the field of machine learning-based analysis of digital pathology images including prostate tissue images. With the help of transfer learning, classification and segmentation…

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