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Liquid-liquid phase separation of aqueous two-phase system (ATPS) is fundamental across physical and biological sciences. While well understood for passive systems, how this process is regulated by active agents such as motile bacteria…

Soft Condensed Matter · Physics 2025-11-25 Dixi Yang , Anheng Wang , Chunming Wang , Hajime Tanaka , Jiaxing Yuan

Liquid-liquid phase separation has emerged as a fundamental mechanism underlying intracellular organization, with evidence for it being reported in numerous different systems. However, there is a growing concern regarding the lack of…

Soft Condensed Matter · Physics 2022-12-09 Mrityunjay Kothari , Tal Cohen

We propose a continuum theory of the liquid-liquid phase separation in an elastic network where phase-separated microscopic droplets rich in one fluid component can form as an interplay of fluids mixing, droplet nucleation, network…

Soft Condensed Matter · Physics 2021-01-04 Xuefeng Wei , Jiajia Zhou , Yanting Wang , Fanlong Meng

Liquid-liquid phase separation is important across biology, physics, and materials science. Although usually studied at equilibrium, active components - such as motor proteins, enzymes, and synthetic microswimmers - are increasingly…

Soft Condensed Matter · Physics 2026-01-06 Kan Chang , Yulin Li , Ming Yuan , Masaki Sano , Zhihong You , H. P. Zhang

Phase separation is the thermodynamic process that explains how droplets form in multicomponent fluids. These droplets can provide controlled compartments to localize chemical reactions, and reactions can also affect the droplets' dynamics.…

Soft Condensed Matter · Physics 2022-09-02 David Zwicker

Swimming cells often have to self-propel through fluids displaying non-Newtonian rheology. While past theoretical work seems to indicate that stresses arising from complex fluids should systematically hinder low-Reynolds number locomotion,…

Biological Physics · Physics 2015-06-30 Yi Man , Eric Lauga

We review understanding of kinetics of fluid phase separation in various space dimensions. Morphological differences, percolating or disconnected, based on overall composition in a binary liquid or density in a vapor-liquid system, have…

Statistical Mechanics · Physics 2020-06-05 Subir K. Das , Sutapa Roy , Jiarul Midya

Recent experimental realizations of liquid-liquid phase separation of active liquid crystals have offered an insight into the interaction between phase separation, ubiquitous in soft matter and biology, and chaotic active flows. In this…

Soft Condensed Matter · Physics 2025-04-23 Paarth Gulati , Fernando Caballero , M. Cristina Marchetti

Various biological and chemical processes lead to the nucleation and growth of non-wetting fluid bubbles within the pore space of a granular medium, such as the formation of gas bubbles in liquid-saturated lake-bed sediments. In…

Soft Condensed Matter · Physics 2022-05-13 Oliver W. Paulin , Liam C. Morrow , Matthew G. Hennessy , Christopher W. MacMinn

A recent study has demonstrated that phase separation in binary liquid mixtures is arrested in the presence of elastic networks and can lead to a nearly uniformly-sized distribution of the dilute-phase droplets. At longer timescales, these…

Soft Condensed Matter · Physics 2020-10-28 Mrityunjay Kothari , Tal Cohen

We extend the continuum theories of active nematohydrodynamics to model a two-fluid mixture with separate velocity fields for each fluid component, coupled through a viscous drag. The model is used to study an active nematic fluid, mixed…

Soft Condensed Matter · Physics 2023-08-02 Saraswat Bhattacharyya , Julia M. Yeomans

The precise control of liquid-liquid phase separation (LLPS) is the key to developing cutting-edge technologies that benefit diverse disciplines. Fluid flow was found to be capable of controlling the structure and effective temperature of…

Fluid Dynamics · Physics 2024-07-04 Yulin Li , Tong Zhou , Yanyu Li , Qi Zhang , Zhihong You

Living and engineered systems rely on the stable coexistence of two interspersed liquid phases. Yet surface tension drives their complete separation. Here we show that stable droplets of uniform and tuneable size can be produced through…

Kinetics of phase separation in a three dimensional single-component Lennard-Jones fluid, that exhibits vapor-liquid transition, is studied via molecular dynamics simulations after quenching homogeneous systems, of different overall…

Statistical Mechanics · Physics 2018-03-09 Sutapa Roy , Subir K. Das

The dynamics of phase separation in multi-component bilayer fluid vesicles is investigated by means of large-scale dissipative particle dynamics. The model explicitly accounts for solvent particles, thereby allowing for the very first…

Soft Condensed Matter · Physics 2009-11-10 Mohamed Laradji , P. B. Sunil Kumar

Membraneless droplets or liquid condensates formed via liquid-liquid phase separation (LLPS) play a pivotal role in cell biology and hold potential for biomedical engineering. While membraneless droplets are often studied in the context of…

Soft Condensed Matter · Physics 2025-11-07 Chenxi Liu , Ding Cao , Siyu Liu , Yilin Wu

Phase separation can drive spatial organization of multicomponent mixtures. For instance in developing animal embryos, effective phase separation descriptions have been used to account for the spatial organization of different tissue types.…

Soft Condensed Matter · Physics 2023-01-18 Simon Gsell , Matthias Merkel

The interplay between phase separation and wetting of multicomponent mixtures is ubiquitous in nature and technology and recently gained significant attention across scientific disciplines, due to the discovery of biomolecular condensates.…

Soft Condensed Matter · Physics 2022-10-14 Youchuang Chao , Olinka Ramirez-Soto , Christian Bahr , Stefan Karpitschka

Phase separation of a liquid mixture embedded within an elastic network is relevant to a wide range of natural and industrial systems, including biomolecular condensates interacting with the cytoskeleton, structural colouring in bird…

Soft Condensed Matter · Physics 2025-08-14 Oliver W. Paulin , Yicheng Qiang , David Zwicker

Droplet breakup is important in many natural and industrial processes, but the current classification of breakup regimes, especially the intermediate breakup regime, is ambiguous. In this study, the transitions of breakup regimes for…

Fluid Dynamics · Physics 2025-04-22 Zhikun Xu , Tianyou Wang , Zhizhao Che
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