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Droplet formation has emerged as an essential concept for the spatiotemporal organisation of biomolecules in cells. However, classical descriptions of droplet dynamics based on passive liquid-liquid phase separation cannot capture the…

Biological Physics · Physics 2025-11-14 David Zwicker , Oliver W. Paulin , Cathelijne ter Burg

We consider the dynamics of thin two-dimensional viscous droplets on chemically heterogeneous surfaces moving under the combined effects of slip, mass transfer and capillarity. The resulting long-wave evolution equation for the droplet…

Fluid Dynamics · Physics 2021-12-20 Danny Groves , Nikos Savva

Aqueous two-phase systems (ATPSs), that is, phase-separating solutions of water soluble but mutually immiscible molecular species, offer fascinating prospects for selective partitioning, purification, and extraction. Here, we formulate a…

Soft Condensed Matter · Physics 2023-11-29 Alberto Scacchi , Carlo Rigoni , Mikko Haataja , Jaakko V. I. Timonen , Maria Sammalkorpi

The two-phase mixing layer formed between parallel gas and liquid streams is an important fundamental problem in turbulent multiphase flows. The problem is relevant to many industrial applications and natural phenomena, such as air-blast…

Fluid Dynamics · Physics 2018-12-05 Y. Ling , D. Fuster , G. Tryggvason , S. Zaleski

Liposomes that achieve a heterogeneous and spatially organized surface through phase separation have been recognized to be a promising platform for delivery purposes. However, their design and optimization through experimentation can be…

Soft Condensed Matter · Physics 2021-11-05 Y. Wang , Y. Palzhanov , A. Quaini , M. Olshanskii , S. Majd

Liquid-liquid phase separation is now recognized as a common mechanism for regulating enzyme activity in cells. Insights from studies in cells are complemented by in vitro studies aimed at developing better understanding of mechanisms…

Biomolecules · Quantitative Biology 2020-10-23 Brian G. O'Flynn , Tanja Mittag

Liquid-liquid phase separation is emerging as a crucial phenomenon in several fundamental cell processes. A range of eukaryotic systems exhibit liquid condensates. However, their function in bacteria, which in general lack membrane-bound…

We investigate the dynamical pathways of a geometric phase transition in a two-dimensional active lattice gas undergoing motility-induced phase separation. The transition is between metastable morphologies of the liquid cluster: a…

Soft Condensed Matter · Physics 2026-01-01 Liheng Yao , Michael E. Cates , Robert L. Jack

We present a minimal model to study liquid phase separation in a fixed pH ensemble. The model describes a mixture composed of macromolecules that exist in three different charge states and have a tendency to phase separate. We introduce the…

Biological Physics · Physics 2020-10-30 Omar Adame-Arana , Christoph A. Weber , Vasily Zaburdaev , Jacques Prost , Frank Jülicher

Droplets abound in nature and technology. In general, they are multicomponent, and, when out of equilibrium, with gradients in concentration, implying flow and mass transport. Moreover, phase transitions can occur, with either evaporation,…

Fluid Dynamics · Physics 2020-05-11 Detlef Lohse , Xuehua Zhang

Active matter, encompassing natural systems, converts surrounding energy to sustain autonomous motion, exhibiting unique non-equilibrium behaviors such as active turbulence and phase separation. In this study, we develop a continuum…

Soft Condensed Matter · Physics 2026-05-06 Sohail Ahmed , Zixiang Lin , Zijie Qu

In this paper, we use the cell dynamics method to study the dynamics of phase transformation when three phases exist. The system we study is a two-dimensional system. The system is able to achieve three phases coexistence, which for…

Materials Science · Physics 2009-11-11 M. Iwamatsu

Fluid membranes made out of lipid bilayers are the fundamental separation structure in eukaryotic cells. Many physiological processes rely on dramatic shape and topological changes (e.g. fusion, fission) of fluid membrane systems. Fluidity…

Numerical Analysis · Mathematics 2010-07-29 Marino Arroyo , Antonio DeSimone , Luca Heltai

Results for the kinetics of vapor-liquid transitions, following temperature quenches with different densities, are presented from the molecular dynamics simulations of a Lennard-Jones system. For critical density, bicontinuous liquid and…

Statistical Mechanics · Physics 2018-03-09 Sutapa Roy , Subir K. Das

Proteins and nucleic acids can spontaneously self-assemble into membraneless droplet-like compartments, both in vitro and in vivo. A key component of these droplets are multi-valent proteins that possess several adhesive domains with…

Biomolecules · Quantitative Biology 2020-01-10 Srivastav Ranganathan , Eugene Shakhnovich

Confined granular fluids, placed in a shallow box that is vibrated vertically, can achieve homogeneous stationary states thanks to energy injection mechanisms that take place throughout the system. These states can be stable even at high…

Soft Condensed Matter · Physics 2015-06-12 Ricardo Brito , Dino Risso , Rodrigo Soto

We analyze motility-induced phase separation and bubbly phase separation in a two-dimensional lattice model of self-propelled particles. We compare systems where the dense (liquid) phase has slab and droplet geometries. We find that…

Soft Condensed Matter · Physics 2025-03-18 Liheng Yao , Robert L. Jack

Understanding the physics of phase-separation between solid and fluid phases as a mixture mass moves down slope is a long-standing challenge. Here, we propose an extension of the two phase mass flow model (Pudasaini, 2012) by including a…

Geophysics · Physics 2022-06-17 Shiva P. Pudasaini , Jan-Thomas Fischer

In biology, cells undergo deformations under the action of flow caused by the fluid surrounding them. These flows lead to shape changes and instabilities that have been explored in detail for single component vesicles. However, cell…

Fluid Dynamics · Physics 2025-10-15 Anirudh Venkatesh , Vivek Narsimhan

We use a continuum model to examine the effect of activity on a phase separating mixture of an extensile active nematic and a passive fluid. We highlight the distinct role of previously considered interfacial active stresses and bulk active…

Soft Condensed Matter · Physics 2022-12-26 Fernando Caballero , M. Cristina Marchetti