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Despite the success of large language models (LLMs) on general-purpose tasks, their performance in highly specialized domains such as biomedicine remains unsatisfactory. A key limitation is the inability of LLMs to effectively leverage…

Computation and Language · Computer Science 2026-05-08 Xin Gao , Ruiyi Zhang , Meixi Du , Peijia Qin , Pengtao Xie

General large language models (LLMs) such as ChatGPT have shown remarkable success. However, such LLMs have not been widely adopted for medical purposes, due to poor accuracy and inability to provide medical advice. We propose IvyGPT, an…

Computation and Language · Computer Science 2023-07-21 Rongsheng Wang , Yaofei Duan , ChanTong Lam , Jiexi Chen , Jiangsheng Xu , Haoming Chen , Xiaohong Liu , Patrick Cheong-Iao Pang , Tao Tan

Large language models (LLMs) have shown remarkable in-context learning (ICL) capabilities, yet their potential for sequential decision-making remains underexplored. In this paper, we study the ICL capabilities of LLMs in sequential…

Machine Learning · Computer Science 2026-05-12 Minmin Zhang , Sina Aghaei , Soroush Saghafian

The integration of Large Language Models (LLMs) into healthcare promises to transform medical diagnostics, research, and patient care. Yet, the progression of medical LLMs faces obstacles such as complex training requirements, rigorous…

Machine Learning · Computer Science 2024-04-26 Emre Can Acikgoz , Osman Batur İnce , Rayene Bench , Arda Anıl Boz , İlker Kesen , Aykut Erdem , Erkut Erdem

The recent progress of large language models (LLMs), including ChatGPT and GPT-4, in comprehending and responding to human instructions has been remarkable. Nevertheless, these models typically perform better in English and have not been…

Computation and Language · Computer Science 2023-04-18 Honglin Xiong , Sheng Wang , Yitao Zhu , Zihao Zhao , Yuxiao Liu , Linlin Huang , Qian Wang , Dinggang Shen

This paper presents the overview of the development and fine-tuning of large language models (LLMs) designed specifically for answering medical questions. We are mainly improving the accuracy and efficiency of providing reliable answers to…

Computation and Language · Computer Science 2025-01-30 Aysegul Ucar , Soumik Nayak , Anunak Roy , Burak Taşcı , Gülay Taşcı

Medical Large Vision-Language Models (Med-LVLMs) demonstrate significant potential in healthcare, but their reliance on general medical data and coarse-grained global visual understanding limits them in intelligent ophthalmic diagnosis.…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Sijing Li , Tianwei Lin , Lingshuai Lin , Wenqiao Zhang , Jiang Liu , Xiaoda Yang , Juncheng Li , Yucheng He , Xiaohui Song , Jun Xiao , Yueting Zhuang , Beng Chin Ooi

For years, semantic interoperability standards have sought to streamline the exchange of clinical data, yet their deployment remains time-consuming, resource-intensive, and technically challenging. To address this, we introduce a…

Computation and Language · Computer Science 2025-07-08 Alvaro Riquelme , Pedro Costa , Catalina Martinez

The recent success of large language models (LLMs) has been largely driven by vast public datasets. However, the next frontier for LLM development lies beyond public data. Much of the world's most valuable information is private, especially…

Widely used language models (LMs) are typically built by scaling up a two-stage training pipeline: a pre-training stage that uses a very large, diverse dataset of text and a fine-tuning (sometimes, 'alignment') stage that uses targeted…

Computation and Language · Computer Science 2023-10-20 Eric Mitchell , Rafael Rafailov , Archit Sharma , Chelsea Finn , Christopher D. Manning

Large Language Models (LLMs) are increasingly deployed in medicine. However, their utility in non-generative clinical prediction, often presumed inferior to specialized models, remains under-evaluated, leading to ongoing debate within the…

Learning never ends, and there is no age limit to grow yourself. However, the educational landscape may face challenges in effectively catering to students' inclusion and diverse learning needs. These students should have access to…

Computers and Society · Computer Science 2024-05-02 Syed Hasib Akhter Faruqui , Nazia Tasnim , Iftekhar Ibne Basith , Suleiman Obeidat , Faruk Yildiz

Large language models (LLMs) are increasingly utilized in healthcare applications. However, their deployment in clinical practice raises significant safety concerns, including the potential spread of harmful information. This study…

Cryptography and Security · Computer Science 2025-03-05 Hang Zhang , Qian Lou , Yanshan Wang

While Large Language Models (LLMs) excel in world knowledge understanding, adapting them to specific subfields requires precise adjustments. Due to the model's vast scale, traditional global fine-tuning methods for large models can be…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Jiawei Chen , Yue Jiang , Dingkang Yang , Mingcheng Li , Jinjie Wei , Ziyun Qian , Lihua Zhang

Supervised fine-tuning (SFT) is a critical step in aligning large language models (LLMs) with human instructions and values, yet many aspects of SFT remain poorly understood. We trained a wide range of base models on a variety of datasets…

Computation and Language · Computer Science 2025-10-31 Yuto Harada , Yusuke Yamauchi , Yusuke Oda , Yohei Oseki , Yusuke Miyao , Yu Takagi

Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

Computation and Language · Computer Science 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

Supervised fine-tuning (SFT) is crucial for aligning Large Language Models (LLMs) with human instructions. The primary goal during SFT is to select a small yet representative subset of training data from the larger pool, such that…

Computation and Language · Computer Science 2024-12-10 Tingyu Xia , Bowen Yu , Kai Dang , An Yang , Yuan Wu , Yuan Tian , Yi Chang , Junyang Lin

Automated Program Repair (APR) aims to fix bugs by generating patches. And existing work has demonstrated that "pre-training and fine-tuning" paradigm enables Large Language Models (LLMs) improve fixing capabilities on APR. However,…

Software Engineering · Computer Science 2024-09-13 Guochang Li , Chen Zhi , Jialiang Chen , Junxiao Han , Shuiguang Deng

Recently, the increasing demand for superior medical services has highlighted the discrepancies in the medical infrastructure. With big data, especially texts, forming the foundation of medical services, there is an exigent need for…

Computation and Language · Computer Science 2024-07-17 Yuanhe Tian , Ruyi Gan , Yan Song , Jiaxing Zhang , Yongdong Zhang

Large Language Models (LLMs), such as GPT3.5, have exhibited remarkable proficiency in comprehending and generating natural language. On the other hand, medical assistants hold the potential to offer substantial benefits for individuals.…

Computation and Language · Computer Science 2024-04-05 Kai Zhang , Yangyang Kang , Fubang Zhao , Xiaozhong Liu