Related papers: AlpaCare:Instruction-tuned Large Language Models f…

Instruction tuning (IT) is crucial to tailoring large language models (LLMs) towards human-centric interactions. Recent advancements have shown that the careful selection of a small, high-quality subset of IT data can significantly enhance…

Fine-tuning on task-specific question-answer pairs is a predominant method for enhancing the performance of instruction-tuned large language models (LLMs) on downstream tasks. However, in certain specialized domains, such as healthcare or…

Instruction tuning is a pivotal technique for aligning large language models (LLMs) with human intentions, safety constraints, and domain-specific requirements. This survey provides a comprehensive overview of the full pipeline,…

To acquire instruction-following capabilities, large language models (LLMs) undergo instruction tuning, where they are trained on instruction-response pairs using next-token prediction (NTP). Efforts to improve instruction tuning often…

When using supervised fine-tuning (SFT) to adapt large language models (LLMs) to specific domains, a significant challenge arises: should we use the entire SFT dataset for fine-tuning? Common practice often involves fine-tuning directly on…

Large language models (LLMs) can potentially democratize access to medical knowledge. While many efforts have been made to harness and improve LLMs' medical knowledge and reasoning capacities, the resulting models are either closed-source…

In-context Learning (ICL) utilizes structured demonstration-query inputs to induce few-shot learning on Language Models (LMs), which are not originally pre-trained on ICL-style data. To bridge the gap between ICL and pre-training, some…

Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses…

Adapting pretrained language models to novel domains, such as clinical applications, traditionally involves retraining their entire set of parameters. Parameter-Efficient Fine-Tuning (PEFT) techniques for fine-tuning language models…

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

Large Language Models (LLMs) have demonstrated significant potential in transforming clinical applications. In this study, we investigate the efficacy of four techniques in adapting LLMs for clinical use-cases: continuous pretraining,…

Large Language Models (LLMs) have demonstrated remarkable adaptability, showcasing their capacity to excel in tasks for which they were not explicitly trained. However, despite their impressive natural language processing (NLP)…

Current Large Language Models (LLMs) exhibit significant limitations, notably in structured, interpretable, and verifiable medical reasoning, alongside practical deployment challenges related to computational resources and data privacy.…

Large Language Models (LLMs) hold significant promise for transforming digital health by enabling automated medical question answering. However, ensuring these models meet critical industry standards for factual accuracy, usefulness, and…

High-quality supervised fine-tuning (SFT) data are crucial for eliciting strong capabilities from pretrained large language models (LLMs). Typically, instructions are paired with multiple responses sampled from other LLMs, which are often…

Instruction finetuning (IFT) is critical for aligning Large Language Models (LLMs) to follow instructions. While many effective IFT datasets have been introduced recently, they predominantly focus on high-resource languages like English. To…

This study presents a comprehensive analysis and comparison of two predominant fine-tuning methodologies - full-parameter fine-tuning and parameter-efficient tuning - within the context of medical Large Language Models (LLMs). We developed…

We evaluate four state-of-the-art instruction-tuned large language models (LLMs) -- ChatGPT, Flan-T5 UL2, Tk-Instruct, and Alpaca -- on a set of 13 real-world clinical and biomedical natural language processing (NLP) tasks in English, such…

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…