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We present a novel neural network architecture, US-Net, for robust nuclei instance segmentation in histopathology images. The proposed framework integrates the nuclei detection and segmentation networks by sharing their outputs through the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-04 Zhaoyang Xu , Faranak Sobhani , Carlos Fernandez Moro , Qianni Zhang

Weakly supervised nuclei segmentation is a critical problem for pathological image analysis and greatly benefits the community due to the significant reduction of labeling cost. Adopting point annotations, previous methods mostly rely on…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Weizhen Liu , Qian He , Xuming He

Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tissues and staining conditions. To address…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kazuya Nishimura , Ryoma Bise , Haruka Hirose , Yasuhiro Kojima

The detection of nuclei and cells in histology images is of great value in both clinical practice and pathological studies. However, multiple reasons such as morphological variations of nuclei or cells make it a challenging task where…

Computer Vision and Pattern Recognition · Computer Science 2021-06-28 Yibao Sun , Xingru Huang , Huiyu Zhou , Qianni Zhang

Recent years have witnessed increasing interests in prompt-based learning in which models can be trained on only a few annotated instances, making them suitable in low-resource settings. When using prompt-based learning for text…

Computation and Language · Computer Science 2023-05-11 Hongjing Li , Hanqi Yan , Yanran Li , Li Qian , Yulan He , Lin Gui

We present a novel usage of Transformers to make image classification interpretable. Unlike mainstream classifiers that wait until the last fully connected layer to incorporate class information to make predictions, we investigate a…

Prompt learning is a new paradigm for utilizing pre-trained language models and has achieved great success in many tasks. To adopt prompt learning in the NER task, two kinds of methods have been explored from a pair of symmetric…

Computation and Language · Computer Science 2023-05-29 Yongliang Shen , Zeqi Tan , Shuhui Wu , Wenqi Zhang , Rongsheng Zhang , Yadong Xi , Weiming Lu , Yueting Zhuang

Despite the growing use of transformer models in computer vision, a mechanistic understanding of these networks is still needed. This work introduces a method to reverse-engineer Vision Transformers trained to solve image classification…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Martina G. Vilas , Timothy Schaumlöffel , Gemma Roig

Image-guided minimally invasive robotic surgery is commonly employed for tasks such as needle biopsies or localized therapies. However, the nonlinear deformation of various tissue types presents difficulties for surgeons in achieving…

Signal Processing · Electrical Eng. & Systems 2024-09-10 Fanxin Wang , Yikun Cheng , Sudipta S Mukherjee , Rohit Bhargava , Thenkurussi Kesavadas

Simultaneous segmentation and classification of nuclei in digital histology play an essential role in computer-assisted cancer diagnosis; however, it remains challenging. The highest achieved binary and multi-class Panoptic Quality (PQ)…

Computer Vision and Pattern Recognition · Computer Science 2024-04-29 Ibtihaj Ahmad , Syed Muhammad Israr , Zain Ul Islam

Segmentation of nuclei regions from histological images enables morphometric analysis of nuclei structures, which in turn helps in the detection and diagnosis of diseases under consideration. To develop a nuclei segmentation algorithm,…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Suman Mahapatra , Pradipta Maji

Sequence classification is the supervised learning task of building models that predict class labels of unseen sequences of symbols. Although accuracy is paramount, in certain scenarios interpretability is a must. Unfortunately, such…

Machine Learning · Computer Science 2020-06-26 Severin Gsponer , Luca Costabello , Chan Le Van , Sumit Pai , Christophe Gueret , Georgiana Ifrim , Freddy Lecue

Purpose: Recent developments in computational pathology have been driven by advances in Vision Foundation Models, particularly the Segment Anything Model (SAM). This model facilitates nuclei segmentation through two primary methods:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Xueyuan Li , Can Cui , Ruining Deng , Yucheng Tang , Quan Liu , Tianyuan Yao , Shunxing Bao , Naweed Chowdhury , Haichun Yang , Yuankai Huo

Transformers have become methods of choice in many applications thanks to their ability to represent complex interactions between elements. However, extending the Transformer architecture to non-sequential data such as molecules and…

Machine Learning · Computer Science 2022-04-27 Yoni Choukroun , Lior Wolf

In the field of face recognition, a model learns to distinguish millions of face images with fewer dimensional embedding features, and such vast information may not be properly encoded in the conventional model with a single branch. We…

Computer Vision and Pattern Recognition · Computer Science 2020-05-26 Yonghyun Kim , Wonpyo Park , Myung-Cheol Roh , Jongju Shin

Histopathology image analysis is critical yet challenged by the demand of segmenting tissue regions and nuclei instances for tumor microenvironment and cellular morphology analysis. Existing studies focused on tissue semantic segmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Qing Xu , Wenting Duan , Zhen Chen

We introduce associative embedding, a novel method for supervising convolutional neural networks for the task of detection and grouping. A number of computer vision problems can be framed in this manner including multi-person pose…

Computer Vision and Pattern Recognition · Computer Science 2017-06-12 Alejandro Newell , Zhiao Huang , Jia Deng

Nuclei appear small in size, yet, in real clinical practice, the global spatial information and correlation of the color or brightness contrast between nuclei and background, have been considered a crucial component for accurate nuclei…

Image and Video Processing · Electrical Eng. & Systems 2023-07-18 Zhenqi He , Mathias Unberath , Jing Ke , Yiqing Shen

Part-based representation has been proven to be effective for a variety of visual applications. However, automatic discovery of discriminative parts without object/part-level annotations is challenging. This paper proposes a discriminative…

Computer Vision and Pattern Recognition · Computer Science 2017-05-30 Xiaopeng Zhang , Hongkai Xiong , Weiyao Lin , Qi Tian

There has been a lot of interest in developing algorithms to extract clusters or communities from networks. This work proposes a method, based on blockmodelling, for leveraging communities and other topological features for use in a…

Social and Information Networks · Computer Science 2011-10-20 Leto Peel