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We consider the problem of distance estimation under the TKF91 model of sequence evolution by insertions, deletions and substitutions on a phylogeny. In an asymptotic regime where the expected sequence lengths tend to infinity, we show that…

Probability · Mathematics 2020-10-29 Wai-Tong Louis Fan , Brandon Legried , Sebastien Roch

In the context of error control in random linear network coding, it is useful to construct codes that comprise well-separated collections of subspaces of a vector space over a finite field. In this paper, the metric used is the so-called…

Information Theory · Computer Science 2009-04-08 Azadeh Khaleghi , Frank R. Kschischang

The rapid development of DNA storage has brought the deletion and insertion channel, once again, to the front line of research. When the number of deletions is equal to the number of insertions, the Fixed Length Levenshtein (FLL) metric is…

Information Theory · Computer Science 2021-06-30 Daniella Bar-Lev , Tuvi Etzion , Eitan Yaakobi

Phylogenetic tree reconstruction is traditionally based on multiple sequence alignments (MSAs) and heavily depends on the validity of this information bottleneck. With increasing sequence divergence, the quality of MSAs decays quickly.…

Populations and Evolution · Quantitative Biology 2011-01-11 Roland F. Schwarz , William Fletcher , Frank Förster , Benjamin Merget , Matthias Wolf , Jörg Schultz , Florian Markowetz

Although recovering an Euclidean distance matrix from noisy observations is a common problem in practice, how well this could be done remains largely unknown. To fill in this void, we study a simple distance matrix estimate based upon the…

Machine Learning · Statistics 2014-09-18 Luwan Zhang , Grace Wahba , Ming Yuan

Generative models are invaluable in many fields of science because of their ability to capture high-dimensional and complicated distributions, such as photo-realistic images, protein structures, and connectomes. How do we evaluate the…

Distances between probability distributions are a key component of many statistical machine learning tasks, from two-sample testing to generative modeling, among others. We introduce a novel distance between measures that compares them…

Machine Learning · Statistics 2025-07-09 Arturo Castellanos , Anna Korba , Pavlo Mozharovskyi , Hicham Janati

Several measures exist for string similarity, including notable ones like the edit distance and the indel distance. The former measures the count of insertions, deletions, and substitutions required to transform one string into another,…

Data Structures and Algorithms · Computer Science 2024-10-15 Sudatta Bhattacharya , Sanjana Dey , Elazar Goldenberg , Michal Koucký

Discrete biological sequence optimization requires iterative refinement under strict syntactic constraints. Diffusion models offer progressive refinement but do not naturally expose controllable discrete edit operations, while…

Computational Engineering, Finance, and Science · Computer Science 2026-03-05 Daiheng Zhang , Shiyang Zhang , Sizhuang He , Yangtian Zhang , Syed Asad Rizvi , David van Dijk

This paper introduces the sequence covering similarity, that we formally define for evaluating the similarity between a symbolic sequence (string) and a set of symbolic sequences (strings). From this covering similarity we derive a…

Data Structures and Algorithms · Computer Science 2018-03-12 Pierre-François Marteau

Frameshift translation is an important phenomenon that contributes to the appearance of novel Coding DNA Sequences (CDS) and functions in gene evolution, by allowing alternative amino acid translations of genes coding regions. Frameshift…

Data Structures and Algorithms · Computer Science 2017-04-14 Safa Jammali , Esaie Kuitche , Ayoub Rachati , François Bélanger , Michelle Scott , Aïda Ouangraoua

Sequence comparison is a prerequisite to virtually all comparative genomic analyses. It is often realized by sequence alignment techniques, which are computationally expensive. This has led to increased research into alignment-free…

Data Structures and Algorithms · Computer Science 2015-12-23 Maxime Crochemore , Gabriele Fici , Robert Mercaş , Solon P. Pissis

Distance metrics and their nonlinear variant play a crucial role in machine learning based real-world problem solving. We demonstrated how Euclidean and cosine distance measures differ not only theoretically but also in real-world medical…

Machine Learning · Computer Science 2021-02-25 Der-Chen Chang , Ophir Frieder , Chi-Feng Hung , Hao-Ren Yao

Semantic Embeddings are a popular way to represent knowledge in the field of zero-shot learning. We observe their interpretability and discuss their potential utility in a safety-critical context. Concretely, we propose to use them to add…

Machine Learning · Statistics 2019-05-21 Thomas Brunner , Frederik Diehl , Michael Truong Le , Alois Knoll

Measuring the distance between data points is fundamental to many statistical techniques, such as dimension reduction or clustering algorithms. However, improvements in data collection technologies has led to a growing versatility of…

Methodology · Statistics 2022-06-20 George Bolt , Simón Lunagómez , Christopher Nemeth

Pairwise sequence comparison is one of the most fundamental problems in string processing. The most common metric to quantify the similarity between sequences S and T is edit distance, d(S,T), which corresponds to the number of characters…

Data Structures and Algorithms · Computer Science 2024-07-04 Ahmet Cemal Alıcıoğlu , Can Alkan

Wasserstein distance, which measures the discrepancy between distributions, shows efficacy in various types of natural language processing (NLP) and computer vision (CV) applications. One of the challenges in estimating Wasserstein distance…

Machine Learning · Statistics 2022-06-27 Makoto Yamada , Yuki Takezawa , Ryoma Sato , Han Bao , Zornitsa Kozareva , Sujith Ravi

Cosine similarity is a popular distance measure that measures the similarity between two vectors in the inner product space. It is widely used in many data classification algorithms like K-Nearest Neighbors, Clustering etc. This study…

Machine Learning · Statistics 2025-02-05 Satyajeet Sahoo , Jhareswar Maiti

This research project aimed to overcome the challenge of analysing human language relationships, facilitate the grouping of languages and formation of genealogical relationship between them by developing automated comparison techniques.…

Computation and Language · Computer Science 2020-02-03 Gabija Mikulyte , David Gilbert

Measuring the distance between ontological elements is fundamental for ontology matching. String-based distance metrics are notorious for shallow syntactic matching. In this exploratory study, we investigate Wasserstein distance targeting…

Artificial Intelligence · Computer Science 2022-09-22 Yuan An , Alex Kalinowski , Jane Greenberg