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Self-supervised learning (SSL) has emerged as a promising paradigm for addressing the annotation bottleneck in medical imaging by learning representations from unlabeled data. However, its effectiveness depends heavily on the design of the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Chathura Wimalasiri

Representation learning for Whole Slide Images (WSIs) is pivotal in developing image-based systems to achieve higher precision in diagnostic pathology. We propose a two-stage framework for WSI representation learning. We sample relevant…

Image and Video Processing · Electrical Eng. & Systems 2020-04-20 Mohammed Adnan , Shivam Kalra , Hamid R. Tizhoosh

Whole slide images (WSIs) are the gold standard for pathological diagnosis and sub-typing. Current main-stream two-step frameworks employ offline feature encoders trained without domain-specific knowledge. Among them, attention-based…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Mingrui Ma , Chentao Li , Pan Huang , Jing Qin

Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Peihang Wu , Zehong Chen , Lijian Xu

Self-supervised learning (SSL) is a machine learning approach where the data itself provides supervision, eliminating the need for external labels. The model is forced to learn about the data structure or context by solving a pretext task.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Markus Marks , Manuel Knott , Neehar Kondapaneni , Elijah Cole , Thijs Defraeye , Fernando Perez-Cruz , Pietro Perona

Self-supervised learning (SSL) has emerged as a powerful paradigm for medical image representation learning, particularly in settings with limited labeled data. However, existing SSL methods often rely on complex architectures,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Azad Singh , Deepak Mishra

Diagnostic, prognostic and therapeutic decision-making of cancer in pathology clinics can now be carried out based on analysis of multi-gigapixel tissue images, also known as whole-slide images (WSIs). Recently, deep convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2022-09-08 Quoc Dang Vu , Kashif Rajpoot , Shan E Ahmed Raza , Nasir Rajpoot

In recent years, semi-supervised learning (SSL) has shown tremendous success in leveraging unlabeled data to improve the performance of deep learning models, which significantly reduces the demand for large amounts of labeled data. Many SSL…

Machine Learning · Computer Science 2020-06-02 Song-Bo Yang , Tian-li Yu

Whole Slide Imaging (WSI) is a cornerstone of digital pathology, offering detailed insights critical for diagnosis and research. Yet, the gigapixel size of WSIs imposes significant computational challenges, limiting their practical utility.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Ravi Kant Gupta , Shounak Das , Amit Sethi

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Classification of gigapixel Whole Slide Images (WSIs) is an important prediction task in the emerging area of computational pathology. There has been a surge of research in deep learning models for WSI classification with clinical…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Sajid Javed , Arif Mahmood , Talha Qaiser , Naoufel Werghi , Nasir Rajpoot

Self-supervised learning (SSL) methods are enabling an increasing number of deep learning models to be trained on image datasets in domains where labels are difficult to obtain. These methods, however, struggle to scale to the high…

Image and Video Processing · Electrical Eng. & Systems 2022-07-07 S. A. Rizvi , P. Cicalese , S. V. Seshan , S. Sciascia , J. U. Becker , H. V. Nguyen

Self-supervised learning (SSL) has emerged as a powerful technique for learning rich representations from unlabeled data. The data representations are able to capture many underlying attributes of data, and be useful in downstream…

Machine Learning · Computer Science 2023-12-01 Weicheng Zhu , Sheng Liu , Carlos Fernandez-Granda , Narges Razavian

Using features extracted from networks pretrained on ImageNet is a common practice in applications of deep learning for digital pathology. However it presents the downside of missing domain specific image information. In digital pathology,…

Computer Vision and Pattern Recognition · Computer Science 2020-01-14 Jacob Gildenblat , Eldad Klaiman

Histopathology whole slide images (WSIs) are being widely used to develop deep learning-based diagnostic solutions, especially for precision oncology. Most of these diagnostic softwares are vulnerable to biases and impurities in the…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Abhijeet Patil , Harsh Diwakar , Jay Sawant , Nikhil Cherian Kurian , Subhash Yadav , Swapnil Rane , Tripti Bameta , Amit Sethi

Although supervised learning has enabled high performance for image segmentation, it requires a large amount of labeled training data, which can be difficult to obtain in the medical imaging field. Self-supervised learning (SSL) methods…

Semantic segmentation of various tissue and nuclei types in histology images is fundamental to many downstream tasks in the area of computational pathology (CPath). In recent years, Deep Learning (DL) methods have been shown to perform well…

Computer Vision and Pattern Recognition · Computer Science 2023-02-14 Raja Muhammad Saad Bashir , Talha Qaiser , Shan E Ahmed Raza , Nasir M. Rajpoot

Over the last decade, supervised deep learning on manually annotated big data has been progressing significantly on computer vision tasks. But the application of deep learning in medical image analysis was limited by the scarcity of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Wei-Chien Wang , Euijoon Ahn , Dagan Feng , Jinman Kim

Task-specific deep learning models in histopathology offer promising opportunities for improving diagnosis, clinical research, and precision medicine. However, development of such models is often limited by availability of high-quality…

Self-supervised learning (SSL) enables label efficient training for machine learning models. This is essential for domains such as medical imaging, where labels are costly and time-consuming to curate. However, the most effective supervised…

Computer Vision and Pattern Recognition · Computer Science 2023-05-16 Cara Van Uden , Jeremy Irvin , Mars Huang , Nathan Dean , Jason Carr , Andrew Ng , Curtis Langlotz