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Atomic level qubits in silicon are attractive candidates for large-scale quantum computing, however, their quantum properties and controllability are sensitive to details such as the number of donor atoms comprising a qubit and their…

Mesoscale and Nanoscale Physics · Physics 2020-03-17 Muhammad Usman , Yi Z. Wong , Charles D. Hill , Lloyd C. L. Hollenberg

As Large Language Models (LLMs) become widely accessible, a detailed understanding of their knowledge within specific domains becomes necessary for successful real world use. This is particularly critical in the domains of medicine and…

The Segment Anything Model (SAM) exhibits a capability to segment a wide array of objects in natural images, serving as a versatile perceptual tool for various downstream image segmentation tasks. In contrast, medical image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Yizhe Zhang , Tao Zhou , Shuo Wang , Ye Wu , Pengfei Gu , Danny Z. Chen

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Comparative knowledge (e.g., steel is stronger and heavier than styrofoam) is an essential component of our world knowledge, yet understudied in prior literature. In this paper, we harvest the dramatic improvements in knowledge capabilities…

Computation and Language · Computer Science 2024-04-09 Phillip Howard , Junlin Wang , Vasudev Lal , Gadi Singer , Yejin Choi , Swabha Swayamdipta

Medication literacy is integral to health literacy, pivotal for medication safety and adherence. It denotes an individual's capacity to discern, comprehend, and convey medication-related information. Existing scales, however, are…

Other Quantitative Biology · Quantitative Biology 2024-05-07 Chen Zhenzhen , Ren Jiabao , Duan Tingyu , Chen Ke , Hou Ruyi , Li Yimiao , Zeng Leixiao , Meng Xiaoxuan , Wu Yibo , Liu Yu

Atomic decomposition -- breaking a candidate answer into claims before verifying each against a reference -- is a widely adopted design for LLM-based reference-grounded judges. However, atomic prompts are typically richer and longer, making…

Computation and Language · Computer Science 2026-03-31 Xinran Zhang

Large Language Models (LLMs) encounter challenges with the unique syntax of specific domains, such as biomolecules. Existing fine-tuning or modality alignment techniques struggle to bridge the domain knowledge gap and understand complex…

Biomolecules · Quantitative Biology 2024-06-28 Jinzhe Liu , Xiangsheng Huang , Zhuo Chen , Yin Fang

Despite the growing application of Large Language Models (LLMs) to theoretical physics, there is little academic exploration into how domain-specific physics reasoning ability develops while training these models. To investigate this, we…

Machine Learning · Computer Science 2026-04-22 Nathaniel S. Woodward , Zhiqi Gao , Yurii Kvasiuk , Kendrick M. Smith , Frederic Sala , Moritz Münchmeyer

Background:Cognitive assessments represent the most common clinical routine for the diagnosis of Alzheimer's Disease (AD). Given a large number of cognitive assessment tools and time-limited office visits, it is important to determine a…

Quantitative Methods · Quantitative Biology 2020-11-16 Bo Peng , Xiaohui Yao , Shannon L. Risacher , Andrew J. Saykin , Li Shen , Xia Ning

High failure rates in cardiac drug development necessitate virtual clinical trials via electrocardiogram (ECG) generation to reduce risks and costs. However, existing ECG generation models struggle to balance morphological realism with…

Machine Learning · Computer Science 2026-03-31 Qian Shao , Bang Du , Zepeng Li , Qiyuan Chen , Jiahe Chen , Hongxia Xu , Jimeng Sun , Jian Wu , Jintai Chen

Quantum-accurate computer simulations play a central role in understanding phase-change materials (PCMs) for advanced memory technologies. However, direct quantum-mechanical simulations are necessarily limited to simplified models,…

Materials Science · Physics 2022-09-20 Yuxing Zhou , Wei Zhang , En Ma , Volker L. Deringer

Methods of computational quantum chemistry provide accurate approximations of molecular properties crucial for computer-aided drug discovery and other areas of chemical science. However, high computational complexity limits the scalability…

This paper proposes a knowledge-enhanced disease diagnosis method based on a prompt learning framework. The method retrieves structured knowledge from external knowledge graphs related to clinical cases, encodes it, and injects it into the…

Computation and Language · Computer Science 2024-09-17 Zhang Zheng

Global machine learning force fields (MLFFs), that have the capacity to capture collective many-atom interactions in molecular systems, currently only scale up to a few dozen atoms due a considerable growth of the model complexity with…

Foundation models (FMs) are catalyzing a transformative shift in materials science (MatSci) by enabling scalable, general-purpose, and multimodal AI systems for scientific discovery. Unlike traditional machine learning models, which are…

Machine Learning · Computer Science 2025-06-27 Minh-Hao Van , Prateek Verma , Chen Zhao , Xintao Wu

Pathology foundation models (PFMs), as large-scale pre-trained models tailored for computational pathology, have significantly advanced a wide range of applications. Their ability to leverage prior knowledge from massive datasets has…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Weiping Lin , Shen Liu , Runchen Zhu , Yixuan Lin , Baoshun Wang , Liansheng Wang

Foundation models (FMs) are driving a prominent shift in biomedical imaging from task-specific models to unified backbone models for diverse tasks. This opens an avenue to integrate imaging, pathology, clinical records, and genomics data…

Quantitative Methods · Quantitative Biology 2026-04-23 Amgad Muneer , Kai Zhang , Ibraheem Hamdi , Rizwan Qureshi , Muhammad Waqas , Shereen Fouad , Hazrat Ali , Syed Muhammad Anwar , Jia Wu

Integrating information from multiple data sources can enable more precise, timely, and generalizable decisions. However, it is challenging to make valid causal inferences using observational data from multiple data sources. For example, in…

Methodology · Statistics 2023-02-08 Larry Han , Yige Li , Bijan A. Niknam , Jose R. Zubizarreta

Foundation medical segmentation models, with MedSAM being the most popular, have achieved promising performance across organs and lesions. However, MedSAM still suffers from compromised performance on specific lesions with intricate…

Quantitative Methods · Quantitative Biology 2025-07-16 Kecheng Chen , Xinyu Luo , Tiexin Qin , Jie Liu , Hui Liu , Victor Ho Fun Lee , Hong Yan , Haoliang Li