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Head computed tomography (CT) imaging is a widely-used imaging modality with multitudes of medical indications, particularly in assessing pathology of the brain, skull, and cerebrovascular system. It is commonly the first-line imaging in…

Large language models have revolutionized artificial intelligence by enabling large, generalizable models trained through self-supervision. This paradigm has inspired the development of scientific foundation models (FMs). However, applying…

The rapid proliferation of open-source medical foundation models (FMs) raises a practical question: how well do their pre-trained representations transfer to clinically relevant but data-scarce classification tasks? Particularly in CT-based…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Hartmut Häntze , Sarah de Boer , Myrthe Buser , Alessa Hering , Bram van Ginneken , Mathias Prokop , Jawed Nawabi , Sebastian Ziegelmayer , Lisa Adams , Keno Bressem

The advent of foundation models (FMs) as an emerging suite of AI techniques has struck a wave of opportunities in computational healthcare. The interactive nature of these models, guided by pre-training data and human instructions, has…

Machine Learning · Computer Science 2026-04-30 Yunkun Zhang , Jin Gao , Zheling Tan , Lingfeng Zhou , Kexin Ding , Mu Zhou , Shaoting Zhang , Dequan Wang

Foundation models pretrained on large-scale datasets are revolutionizing the field of computational pathology (CPath). The generalization ability of foundation models is crucial for the success in various downstream clinical tasks. However,…

Scientific texts often convey authority due to their technical language and complex data. However, this complexity can sometimes lead to the spread of misinformation. Non-experts are particularly susceptible to misleading claims based on…

Computation and Language · Computer Science 2025-06-10 Yuji Zhang , Qingyun Wang , Cheng Qian , Jiateng Liu , Chenkai Sun , Denghui Zhang , Tarek Abdelzaher , Chengxiang Zhai , Preslav Nakov , Heng Ji

Multi-omics research has enhanced our understanding of cancer heterogeneity and progression. Investigating molecular data through multi-omics approaches is crucial for unraveling the complex biological mechanisms underlying cancer, thereby…

Foundation models (FMs), i.e., models trained on a vast amount of typically unlabeled data, have become popular and available recently for the domain of histopathology. The key idea is to extract semantically rich vectors from any input…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Jonathan Ganz , Jonas Ammeling , Emely Rosbach , Ludwig Lausser , Christof A. Bertram , Katharina Breininger , Marc Aubreville

Brain Foundation Models (BFMs) are transforming neuroscience by enabling scalable and transferable learning from neural signals, advancing both clinical diagnostics and cutting-edge neuroscience exploration. Their emergence is powered by…

Machine Learning · Computer Science 2026-02-13 Fanqi Shen , Enhong Yang , Jiahe Li , Junru Hong , Xiaoran Pan , Zhizhang Yuan , Meng Li , Yang Yang

Vision foundation models (FMs) are accelerating the development of digital pathology algorithms and transforming biomedical research. These models learn, in a self-supervised manner, to represent histological features in highly…

Foundation Models (FMs) are models trained on large corpora of data that, at very large scale, can generalize to new tasks without any task-specific finetuning. As these models continue to grow in size, innovations continue to push the…

Machine Learning · Computer Science 2022-12-27 Avanika Narayan , Ines Chami , Laurel Orr , Simran Arora , Christopher Ré

Foundation Models (FMs) have shown impressive performance on various text and image processing tasks. They can generalize across domains and datasets in a zero-shot setting. This could make them suitable for automated quality inspection…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Simon Baeuerle , Pratik Khanna , Nils Friederich , Angelo Jovin Yamachui Sitcheu , Damir Shakirov , Andreas Steimer , Ralf Mikut

Foundation models have demonstrated remarkable capabilities in handling diverse modalities and tasks, outperforming conventional artificial intelligence (AI) approaches that are highly task-specific and modality-reliant. In the medical…

Machine Learning · Computer Science 2025-05-06 Xiaochen Wang , Jiaqi Wang , Houping Xiao , Jinghui Chen , Fenglong Ma

Recent advancements in large language models (LLMs) have transformed the field of question answering (QA). However, evaluating LLMs in the medical field is challenging due to the lack of standardized and comprehensive datasets. To address…

Computation and Language · Computer Science 2023-10-24 Junling Liu , Peilin Zhou , Yining Hua , Dading Chong , Zhongyu Tian , Andrew Liu , Helin Wang , Chenyu You , Zhenhua Guo , Lei Zhu , Michael Lingzhi Li

Recent advancements in artificial intelligence (AI), particularly foundation models (FMs), have revolutionized medical image analysis, demonstrating strong zero- and few-shot performance across diverse medical imaging tasks, from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Praveenbalaji Rajendran , Mojtaba Safari , Wenfeng He , Mingzhe Hu , Shansong Wang , Jun Zhou , Xiaofeng Yang

Machine learning force fields have emerged as promising tools for molecular dynamics (MD) simulations, potentially offering quantum-mechanical accuracy with the efficiency of classical MD. Inspired by foundational large language models,…

Computational Physics · Physics 2025-11-14 Denan Li , Jiyuan Yang , Xiangkai Chen , Lintao Yu , Shi Liu

This study introduces the Federated Medical Knowledge Injection (FEDMEKI) platform, a new benchmark designed to address the unique challenges of integrating medical knowledge into foundation models under privacy constraints. By leveraging a…

Artificial Intelligence · Computer Science 2024-08-20 Jiaqi Wang , Xiaochen Wang , Lingjuan Lyu , Jinghui Chen , Fenglong Ma

Foundation models (FMs) promise to generalize medical imaging, but their effectiveness varies. It remains unclear how pre-training domain (medical vs. general), paradigm (e.g., text-guided), and architecture influence embedding quality,…

AI methods are increasingly shaping pharmaceutical drug discovery. However, their translation to industrial applications remains limited due to their reliance on public datasets, lacking scale and diversity of proprietary pharmaceutical…

Machine Learning · Computer Science 2026-05-07 Markus Bujotzek , Evelyn Trautmann , Calum Hand , Ian Hales

Machine-learned interatomic potentials have transformed computational research in the physical sciences. Recent atomistic `foundation' models have changed the field yet again: trained on many different chemical elements and domains, these…

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