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Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Continual instruction tuning(CIT) during the post-training phase is crucial for adapting multimodal large language models (MLLMs) to evolving real-world demands. However, the progress is hampered by the lack of benchmarks with rigorous,…

Large language models (LLMs) have demonstrated exceptional performance in various NLP applications. However, the majority of existing open-source LLMs are pre-trained primarily on English data and little part of other languages. This…

Due to the continuous emergence of new data, version updates have become an indispensable requirement for Large Language Models (LLMs). The training paradigms for version updates of LLMs include pre-training from scratch (PTFS) and…

Improving Multi-modal Large Language Models (MLLMs) in the post-training stage typically relies on supervised fine-tuning (SFT) or reinforcement learning (RL), which require expensive and manually annotated multi-modal data--an ultimately…

Developing therapeutics is a lengthy and expensive process that requires the satisfaction of many different criteria, and AI models capable of expediting the process would be invaluable. However, the majority of current AI approaches…

To enhance the performance of large language models (LLMs) in biomedical natural language processing (BioNLP) by introducing a domain-specific instruction dataset and examining its impact when combined with multi-task learning principles.…

We present an advanced approach to medical question-answering (QA) services, using fine-tuned Large Language Models (LLMs) to improve the accuracy and reliability of healthcare information. Our study focuses on optimizing models like…

Multimodal large language models (MLLMs) have made rapid progress, yet their reasoning ability often lags behind strong text-only LLMs. Bridging this gap typically requires large-scale multimodal reasoning data or reinforcement learning,…

Large language models (LLMs) have demonstrated remarkable performance on various medical benchmarks, but their capabilities across different cognitive levels remain underexplored. Inspired by Bloom's Taxonomy, we propose a…

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensuring accuracy, safety, and ethical alignment. Existing frameworks inadequately dissect domain-specific…

Despite the success of large language models (LLMs) in various domains, their potential in Traditional Chinese Medicine (TCM) remains largely underexplored due to two critical barriers: (1) the scarcity of high-quality TCM data and (2) the…

Digital health analytics face critical challenges nowadays. The sophisticated analysis of patient-generated health content, which contains complex emotional and medical contexts, requires scarce domain expertise, while traditional ML…

The emergence of various medical large language models (LLMs) in the medical domain has highlighted the need for unified evaluation standards, as manual evaluation of LLMs proves to be time-consuming and labor-intensive. To address this…

Large Language Models (LLMs) have achieved remarkable success across various domains. However, a fundamental question remains: Can LLMs effectively utilize causal knowledge for prediction and generation? Through empirical studies, we find…

Accurate estimation of postmenstrual age (PMA) at scan is crucial for assessing neonatal development and health. While deep learning models have achieved high accuracy in predicting PMA from brain MRI, they often function as black boxes,…

This paper explores the development of the Six Stages of Information Search Model and its enhancement through the application of the Large Language Model (LLM) powered Information Search Processes (ISP) in healthcare. The Six Stages Model,…

Accurate symptom-to-disease classification and clinically grounded treatment recommendations remain challenging, particularly in heterogeneous patient settings with high diagnostic risk. Existing large language model (LLM)-based systems…

Large language models (LLMs) have significantly advanced human language understanding and generation, with pretraining data quality and organization being crucial to their performance. Multi-stage pretraining is a promising approach, but…