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Large language models (LLMs) have shown remarkable performance on many tasks in different domains. However, their performance in closed-book biomedical machine reading comprehension (MRC) has not been evaluated in depth. In this work, we…

Computation and Language · Computer Science 2024-10-28 Shubham Vatsal , Ayush Singh

Large language models (LLMs) have exhibited impressive reasoning abilities on a wide range of complex tasks. However, enhancing these capabilities through post-training remains resource intensive, particularly in terms of data and…

Artificial Intelligence · Computer Science 2025-08-13 Shuo Cai , Su Lu , Qi Zhou , Kejing Yang , Zhijie Sang , Congkai Xie , Hongxia Yang

Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

Machine Learning · Computer Science 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

This study addresses key challenges in developing domain-specific large language models (LLMs) for Chinese state-owned assets and enterprises (SOAEs), where current approaches face three limitations: 1) constrained model capacity that…

Computation and Language · Computer Science 2025-05-09 Jingyang Deng , Ran Chen , Jo-Ku Cheng , Jinwen Ma

Cancer staging is critical for patient prognosis and treatment planning, yet extracting pathologic TNM staging from unstructured pathology reports poses a persistent challenge. Existing natural language processing (NLP) and machine learning…

Artificial Intelligence · Computer Science 2025-11-04 Yeawon Lee , Christopher C. Yang , Chia-Hsuan Chang , Grace Lu-Yao

In this study, we introduce CT-LLM, a 2B large language model (LLM) that illustrates a pivotal shift towards prioritizing the Chinese language in developing LLMs. Uniquely initiated from scratch, CT-LLM diverges from the conventional…

Large Language Models (LLMs) have made significant progress in various fields. However, challenges remain in Multi-Disciplinary Team (MDT) medical consultations. Current research enhances reasoning through role assignment, task…

Artificial Intelligence · Computer Science 2025-03-19 Kai Chen , Xinfeng Li , Tianpei Yang , Hewei Wang , Wei Dong , Yang Gao

The advancement of large language models (LLMs) has opened new frontiers in natural language processing, particularly in specialized domains like healthcare. In this paper, we propose the Incremental Curriculum-Based Fine-Tuning (ICFT)…

Computation and Language · Computer Science 2025-02-04 Robert Long , Eric Gonzalez , Harrison Fuller

Reinforcement learning (RL)-based dynamic treatment regimes (DTRs) hold promise for automating complex clinical decision-making, yet their practical deployment remains hindered by the intensive engineering required to inject clinical…

Machine Learning · Computer Science 2025-08-08 Zhiyao Luo , Tingting Zhu

Large Language Models (LLMs) have demonstrated remarkable capabilities in modern medicine, yet their application in Traditional Chinese Medicine (TCM) remains severely limited by the absence of standardized benchmarks and the scarcity of…

Computation and Language · Computer Science 2025-12-29 Zihao Cheng , Yuheng Lu , Huaiqian Ye , Zeming Liu , Minqi Wang , Jingjing Liu , Zihan Li , Wei Fan , Yuanfang Guo , Ruiji Fu , Shifeng She , Gang Wang , Yunhong Wang

Large language models (LLMs) are typically trained on general source data for various domains, but a recent surge in domain-specific LLMs has shown their potential to outperform general-purpose models in domain-specific tasks (e.g.,…

Computation and Language · Computer Science 2024-08-09 Vithursan Thangarasa , Mahmoud Salem , Shreyas Saxena , Kevin Leong , Joel Hestness , Sean Lie

Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

Computation and Language · Computer Science 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Scientific literature understanding is crucial for extracting targeted information and garnering insights, thereby significantly advancing scientific discovery. Despite the remarkable success of Large Language Models (LLMs), they face…

Machine Learning · Computer Science 2025-04-21 Sihang Li , Jin Huang , Jiaxi Zhuang , Yaorui Shi , Xiaochen Cai , Mingjun Xu , Xiang Wang , Linfeng Zhang , Guolin Ke , Hengxing Cai

Large language models (LLMs) are increasingly applied in computer science education for tasks such as tutoring, content generation, and code assessment. However, systematic evaluations aligned with formal curricula and certification…

Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

Computation and Language · Computer Science 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

Enhancing the reasoning capabilities of Large Language Models (LLMs) with efficiency and scalability remains a fundamental challenge in artificial intelligence research. This paper presents a rigorous experimental investigation into how…

Computation and Language · Computer Science 2025-04-02 Yunjie Ji , Sitong Zhao , Xiaoyu Tian , Haotian Wang , Shuaiting Chen , Yiping Peng , Han Zhao , Xiangang Li

Continual pre-training (CPT) has been an important approach for adapting language models to specific domains or tasks. To make the CPT approach more traceable, this paper presents a technical report for continually pre-training Llama-3…

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

The biomedical field relies heavily on concept linking in various areas such as literature mining, graph alignment, information retrieval, question-answering, data, and knowledge integration. Although large language models (LLMs) have made…

Computation and Language · Computer Science 2023-07-04 Qinyong Wang , Zhenxiang Gao , Rong Xu

High computation costs and latency of large language models such as GPT-4 have limited their deployment in clinical settings. Small language models (SLMs) offer a cost-effective alternative, but their limited capacity requires biomedical…

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