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Trained classification models can unintentionally lead to biased representations and predictions, which can reinforce societal preconceptions and stereotypes. Existing debiasing methods for classification models, such as adversarial…

Computation and Language · Computer Science 2021-09-23 Aili Shen , Xudong Han , Trevor Cohn , Timothy Baldwin , Lea Frermann

Single-cell RNA sequencing (scRNA-seq) data is a potent tool for comprehending the "language of life" and can provide insights into various downstream biomedical tasks. Large-scale language models (LLMs) are starting to be used for cell…

Computational Engineering, Finance, and Science · Computer Science 2023-06-08 Suyuan Zhao , Jiahuan Zhang , Zaiqing Nie

Semantic search is an important task which objective is to find the relevant index from a database for query. It requires a retrieval model that can properly learn the semantics of sentences. Transformer-based models are widely used as…

Machine Learning · Computer Science 2022-09-28 Mingxi Tan , Alexis Rolland , Andong Tian

Multimodal contrastive learning is a methodology for linking different data modalities; the canonical example is linking image and text data. The methodology is typically framed as the identification of a set of encoders, one for each…

Machine Learning · Statistics 2025-06-02 Ricardo Baptista , Andrew M. Stuart , Son Tran

Self-supervised learning has proven to be an effective way to learn representations in domains where annotated labels are scarce, such as medical imaging. A widely adopted framework for this purpose is contrastive learning and it has been…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Hugo Figueiras , Helena Aidos , Nuno Cruz Garcia

Contrastive learning has become a key component of self-supervised learning approaches for graph-structured data. Despite their success, existing graph contrastive learning methods are incapable of uncertainty quantification for node…

Predicting the secondary structure of RNA is a core challenge in computational biology, essential for understanding molecular function and designing novel therapeutics. The field has evolved from foundational but accuracy-limited…

Biomolecules · Quantitative Biology 2026-05-20 Giuseppe Sacco , Giovanni Bussi , Guido Sanguinetti

To improve performance in visual feature representation from photos or videos for practical applications, we generally require large-scale human-annotated labeled data while training deep neural networks. However, the cost of gathering and…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Zhenyuan Lu

Contrastive learning produces coherent semantic feature embeddings by encouraging positive samples to cluster closely while separating negative samples. However, existing contrastive learning methods lack principled guarantees on coverage…

Machine Learning · Computer Science 2026-03-30 Yahya Alkhatib , Wee Peng Tay

Training dense passage representations via contrastive learning has been shown effective for Open-Domain Passage Retrieval (ODPR). Existing studies focus on further optimizing by improving negative sampling strategy or extra pretraining.…

Computation and Language · Computer Science 2022-03-08 Bohong Wu , Zhuosheng Zhang , Jinyuan Wang , Hai Zhao

Humans rely on effective representations to learn from few examples and abstract useful information from sensory data. Inducing such representations in machine learning models has been shown to improve their performance on various…

Machine Learning · Computer Science 2025-02-03 Raja Marjieh , Sreejan Kumar , Declan Campbell , Liyi Zhang , Gianluca Bencomo , Jake Snell , Thomas L. Griffiths

Contrastive Learning has recently received interest due to its success in self-supervised representation learning in the computer vision domain. However, the origins of Contrastive Learning date as far back as the 1990s and its development…

Machine Learning · Computer Science 2020-10-29 Phuc H. Le-Khac , Graham Healy , Alan F. Smeaton

A single gene can encode for different protein versions through a process called alternative splicing. Since proteins play major roles in cellular functions, aberrant splicing profiles can result in a variety of diseases, including cancers.…

Genomics · Quantitative Biology 2021-03-09 Alvin Chan , Anna Korsakova , Yew-Soon Ong , Fernaldo Richtia Winnerdy , Kah Wai Lim , Anh Tuan Phan

Contrastive representation learning has emerged as a promising technique for continual learning as it can learn representations that are robust to catastrophic forgetting and generalize well to unseen future tasks. Previous work in…

Computer Vision and Pattern Recognition · Computer Science 2023-11-06 Rouzbeh Meshkinnejad , Jie Mei , Daniel Lizotte , Yalda Mohsenzadeh

How can you sample good negative examples for contrastive learning? We argue that, as with metric learning, contrastive learning of representations benefits from hard negative samples (i.e., points that are difficult to distinguish from an…

Machine Learning · Computer Science 2021-01-26 Joshua Robinson , Ching-Yao Chuang , Suvrit Sra , Stefanie Jegelka

Contrastive learning (CL), a self-supervised learning approach, can effectively learn visual representations from unlabeled data. Given the CL training data, generative models can be trained to generate synthetic data to supplement the real…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Yawen Wu , Zhepeng Wang , Dewen Zeng , Yiyu Shi , Jingtong Hu

Contrastive learning has emerged as an essential approach for self-supervised learning in visual representation learning. The central objective of contrastive learning is to maximize the similarities between two augmented versions of an…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Hengkui Dong , Xianzhong Long , Yun Li , Lei Chen

Self-supervised representation learning of biological sequence embeddings alleviates computational resource constraints on downstream tasks while circumventing expensive experimental label acquisition. However, existing methods mostly…

Biomolecules · Quantitative Biology 2020-12-29 Amy X. Lu , Alex X. Lu , Alan Moses

Contrastive learning -- a modern approach to extract useful representations from unlabeled data by training models to distinguish similar samples from dissimilar ones -- has driven significant progress in foundation models. In this work, we…

Machine Learning · Statistics 2025-10-15 Licong Lin , Song Mei

Contrastive learning (CL) methods effectively learn data representations in a self-supervision manner, where the encoder contrasts each positive sample over multiple negative samples via a one-vs-many softmax cross-entropy loss. By…

Machine Learning · Computer Science 2023-08-16 Huangjie Zheng , Xu Chen , Jiangchao Yao , Hongxia Yang , Chunyuan Li , Ya Zhang , Hao Zhang , Ivor Tsang , Jingren Zhou , Mingyuan Zhou