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Objective: To enable privacy-preserving learning of high quality generative and discriminative machine learning models from distributed electronic health records. Methods and Results: We describe general and scalable strategy to build…

Cryptography and Security · Computer Science 2018-06-19 Marina Blanton , Ah Reum Kang , Subhadeep Karan , Jaroslaw Zola

Privacy is crucial in many applications of machine learning. Legal, ethical and societal issues restrict the sharing of sensitive data making it difficult to learn from datasets that are partitioned between many parties. One important…

Machine Learning · Statistics 2018-09-21 Christina Heinze-Deml , Brian McWilliams , Nicolai Meinshausen

Applying machine learning (ML) to sensitive domains requires privacy protection of the underlying training data through formal privacy frameworks, such as differential privacy (DP). Yet, usually, the privacy of the training data comes at…

Machine Learning · Computer Science 2022-11-09 Franziska Boenisch , Christopher Mühl , Roy Rinberg , Jannis Ihrig , Adam Dziedzic

Integrating information from multiple data sources can enable more precise, timely, and generalizable decisions. However, it is challenging to make valid causal inferences using observational data from multiple data sources. For example, in…

Methodology · Statistics 2023-02-08 Larry Han , Yige Li , Bijan A. Niknam , Jose R. Zubizarreta

With growing concerns about user data collection, individualized privacy has emerged as a promising solution to balance protection and utility by accounting for diverse user privacy preferences. Instead of enforcing a uniform level of…

Machine Learning · Computer Science 2026-02-04 Lucas Lange , Ole Borchardt , Erhard Rahm

The classical machine learning paradigm requires the aggregation of user data in a central location where machine learning practitioners can preprocess data, calculate features, tune models and evaluate performance. The advantage of this…

In many practical situations, randomly assigning treatments to subjects is uncommon due to feasibility constraints. For example, economic aid programs and merit-based scholarships are often restricted to those meeting specific income or…

Due to medical data privacy regulations, it is often infeasible to collect and share patient data in a centralised data lake. This poses challenges for training machine learning algorithms, such as deep convolutional networks, which often…

Computer Vision and Pattern Recognition · Computer Science 2019-10-03 Wenqi Li , Fausto Milletarì , Daguang Xu , Nicola Rieke , Jonny Hancox , Wentao Zhu , Maximilian Baust , Yan Cheng , Sébastien Ourselin , M. Jorge Cardoso , Andrew Feng

Federated learning (FL) takes a first step towards privacy-preserving machine learning by training models while keeping client data local. Models trained using FL may still leak private client information through model updates during…

Machine Learning · Computer Science 2023-01-18 Nasser Aldaghri , Hessam Mahdavifar , Ahmad Beirami

Constructing confidence intervals (CIs) for the average treatment effect (ATE) from patient records is crucial to assess the effectiveness and safety of drugs. However, patient records typically come from different hospitals, thus raising…

Machine Learning · Computer Science 2025-10-16 Yuxin Wang , Maresa Schröder , Dennis Frauen , Jonas Schweisthal , Konstantin Hess , Stefan Feuerriegel

Privacy and algorithmic fairness have become two central issues in modern machine learning. Although each has separately emerged as a rapidly growing research area, their joint effect remains comparatively under-explored. In this paper, we…

Machine Learning · Statistics 2026-03-26 Gengyu Xue , Yi Yu

Average Treatment Effect (ATE) estimation is a well-studied problem in causal inference. However, it does not necessarily capture the heterogeneity in the data, and several approaches have been proposed to tackle the issue, including…

Machine Learning · Computer Science 2024-03-19 Raghavendra Addanki , Siddharth Bhandari

The estimation of average treatment effects (ATEs), defined as the difference in expected outcomes between treatment and control groups, is a central topic in causal inference. This study develops semiparametric efficient estimators for ATE…

Machine Learning · Computer Science 2025-05-29 Masahiro Kato , Fumiaki Kozai , Ryo Inokuchi

Collaborative machine learning techniques such as federated learning (FL) enable the training of models on effectively larger datasets without data transfer. Recent initiatives have demonstrated that segmentation models trained with FL can…

Image and Video Processing · Electrical Eng. & Systems 2021-07-07 Alexander Ziller , Dmitrii Usynin , Nicolas Remerscheid , Moritz Knolle , Marcus Makowski , Rickmer Braren , Daniel Rueckert , Georgios Kaissis

Differential privacy is the leading mathematical framework for privacy protection, providing a probabilistic guarantee that safeguards individuals' private information when publishing statistics from a dataset. This guarantee is achieved by…

Methodology · Statistics 2025-08-19 Yuki Ohnishi , Jordan Awan

Federated learning has emerged as an attractive approach to protect data privacy by eliminating the need for sharing clients' data while reducing communication costs compared with centralized machine learning algorithms. However, recent…

How can agents exchange information to learn while protecting privacy? Healthcare centers collaborating on clinical trials must balance knowledge sharing with safeguarding sensitive patient data. We address this challenge by using…

Machine Learning · Computer Science 2025-03-19 Marios Papachristou , M. Amin Rahimian

With increasing concerns over privacy in healthcare, especially for sensitive medical data, this research introduces a federated learning framework that combines local differential privacy and secure aggregation using Secure Multi-Party…

Machine Learning · Computer Science 2024-12-03 Mohamad Haj Fares , Ahmed Mohamed Saad Emam Saad

Federated learning (FL) is a distributed machine learning technique designed to preserve data privacy and security, and it has gained significant importance due to its broad range of applications. This paper addresses the problem of optimal…

Statistics Theory · Mathematics 2025-01-16 Tony Cai , Abhinav Chakraborty , Lasse Vuursteen

There is intense interest in applying machine learning to problems of causal inference in fields such as healthcare, economics and education. In particular, individual-level causal inference has important applications such as precision…

Machine Learning · Statistics 2017-05-17 Uri Shalit , Fredrik D. Johansson , David Sontag