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Federated or multi-site studies have distinct advantages over single-site studies, including increased generalizability, the ability to study underrepresented populations, and the opportunity to study rare exposures and outcomes. However,…

Machine Learning · Statistics 2023-09-25 Larry Han , Zhu Shen , Jose Zubizarreta

Protecting sensitive health data while enabling collaborative analysis is a central challenge in healthcare. Traditional machine learning (ML) requires institutions to pool anonymized patient records, centralizing analytical development and…

Machine Learning · Computer Science 2026-05-05 Gaurang Sharma , Juha Pajula , Aada Illikainen , Markus Rautell , Noora Lipsonen , Petri Alhainen , Mika Hilvo

Prevention of stroke with its associated risk factors has been one of the public health priorities worldwide. Emerging artificial intelligence technology is being increasingly adopted to predict stroke. Because of privacy concerns, patient…

Machine Learning · Computer Science 2020-12-16 Ce Ju , Ruihui Zhao , Jichao Sun , Xiguang Wei , Bo Zhao , Yang Liu , Hongshan Li , Tianjian Chen , Xinwei Zhang , Dashan Gao , Ben Tan , Han Yu , Chuning He , Yuan Jin

Federated Learning (FL) offers a promising approach for training clinical AI models without centralizing sensitive patient data. However, its real-world adoption is hindered by challenges related to privacy, resource constraints, and…

Estimating individualised treatment effect (ITE) -- that is the causal effect of a set of variables (also called exposures, treatments, actions, policies, or interventions), referred to as \textit{composite treatments}, on a set of outcome…

Machine Learning · Computer Science 2025-12-19 Vinod Kumar Chauhan , Lei Clifton , Gaurav Nigam , David A. Clifton

One-shot federated learning enables multi-site inference with minimal communication. However, sharing summary statistics can still leak sensitive individual-level information when sites have only a small number of patients. In particular,…

Methodology · Statistics 2026-04-02 Keisuke Hanada , Toshio Shimokawa , Kazushi Maruo

We study Federated Causal Inference, an approach to estimate treatment effects from decentralized data across centers. We compare three classes of Average Treatment Effect (ATE) estimators derived from the Plug-in G-Formula, ranging from…

Machine Learning · Statistics 2025-03-26 Rémi Khellaf , Aurélien Bellet , Julie Josse

When learning from sensitive data, care must be taken to ensure that training algorithms address privacy concerns. The canonical Private Aggregation of Teacher Ensembles, or PATE, computes output labels by aggregating the predictions of a…

Machine Learning · Computer Science 2022-09-23 Jiaqi Wang , Roei Schuster , Ilia Shumailov , David Lie , Nicolas Papernot

The proliferation of deep learning applications in healthcare calls for data aggregation across various institutions, a practice often associated with significant privacy concerns. This concern intensifies in medical image analysis, where…

Machine Learning · Computer Science 2023-07-03 Kishore Babu Nampalle , Pradeep Singh , Uppala Vivek Narayan , Balasubramanian Raman

In response to the growing need for generating real-world evidence from multi-site collaborative studies, we introduce an efficient collaborative learning approach to evaluate average treatment effect (ECO-ATE) in a multi-site setting under…

Methodology · Statistics 2026-04-09 Sijia Li , Rui Duan

Deep learning models have shown their advantage in many different tasks, including neuroimage analysis. However, to effectively train a high-quality deep learning model, the aggregation of a significant amount of patient information is…

Machine Learning · Computer Science 2020-12-08 Xiaoxiao Li , Yufeng Gu , Nicha Dvornek , Lawrence Staib , Pamela Ventola , James S. Duncan

Analyzing data from multiple sources offers valuable opportunities to improve the estimation efficiency of causal estimands. However, this analysis also poses many challenges due to population heterogeneity and data privacy constraints.…

Methodology · Statistics 2025-10-23 Rong Zhao , Jason Falvey , Xu Shi , Vernon M. Chinchilli , Chixiang Chen

Survival analysis or time-to-event analysis aims to model and predict the time it takes for an event of interest to happen in a population or an individual. In the medical context this event might be the time of dying, metastasis,…

Machine Learning · Computer Science 2022-02-09 Shadi Rahimian , Raouf Kerkouche , Ina Kurth , Mario Fritz

The Private Aggregation of Teacher Ensembles (PATE) is a machine learning framework that enables the creation of private models through the combination of multiple "teacher" models and a "student" model. The student model learns to predict…

Machine Learning · Computer Science 2023-05-22 Cuong Tran , Ferdinando Fioretto

In the social and health sciences, researchers often make causal inferences using sensitive variables. These researchers, as well as the data holders themselves, may be ethically and perhaps legally obligated to protect the confidentiality…

Methodology · Statistics 2024-08-28 Sharmistha Guha , Jerome P. Reiter

Causal inference typically assumes centralized access to individual-level data. Yet, in practice, data are often decentralized across multiple sites, making centralization infeasible due to privacy, logistical, or legal constraints. We…

Methodology · Statistics 2026-02-04 Rémi Khellaf , Aurélien Bellet , Julie Josse

Automated recognition of autistic behaviors in children is essential for early intervention and objective clinical assessment. However, the development of robust models is severely hindered by strict privacy regulations (e.g., HIPAA) and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Guangyu Sun , Wenhan Wu , Zhishuai Guo , Ziteng Wang , Pegah Khosravi , Chen Chen

Federated learning has emerged as a powerful framework for analysing distributed data, yet two challenges remain pivotal: heterogeneity across sites and privacy of local data. In this paper, we address both challenges within a federated…

Machine Learning · Computer Science 2026-04-07 Mengchu Li , Ye Tian , Yang Feng , Yi Yu

The growing development of artificial intelligence based solutions, together with privacy legislation, has driven the rise of the so-called privacy preserving machine learning architectures, such as federated learning. While federated…

Cryptography and Security · Computer Science 2026-05-05 Judith Sáinz-Pardo Díaz , Álvaro López García

Large volumes of medical data remain underutilized because centralizing distributed data is often infeasible due to strict privacy regulations and institutional constraints. In addition, models trained in centralized settings frequently…

Image and Video Processing · Electrical Eng. & Systems 2026-05-12 Puja Saha , Eranga Ukwatta