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Generative models can be categorized into two types: explicit generative models that define explicit density forms and allow exact likelihood inference, such as score-based diffusion models (SDMs) and normalizing flows; implicit generative…

Machine Learning · Statistics 2023-07-06 Jingwei Zhang , Han Shi , Jincheng Yu , Enze Xie , Zhenguo Li

Artificial intelligence (AI) is increasingly used in every stage of drug development. Continuing breakthroughs in AI-based methods for drug discovery require the creation, improvement, and refinement of drug discovery data. We posit a new…

Machine Learning · Computer Science 2024-05-08 Bing Hu , Ashish Saragadam , Anita Layton , Helen Chen

We introduce Discrete Voxel Diffusion (DVD), a discrete diffusion framework to generate, assess, and edit sparse voxels for SLat (Structured LATent) based 3D generative pipelines. Although discrete diffusion has not generally displaced…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Zhengrui Xiang , Jiaqi Wu , Fupeng Sun , Heliang Zheng , Yingzhen Li

Latent diffusion models have emerged as the leading approach for generating high-quality images and videos, utilizing compressed latent representations to reduce the computational burden of the diffusion process. While recent advancements…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Ivan Skorokhodov , Sharath Girish , Benran Hu , Willi Menapace , Yanyu Li , Rameen Abdal , Sergey Tulyakov , Aliaksandr Siarohin

Machine Learning (ML) is accelerating progress across fields and industries, but relies on accessible and high-quality training data. Some of the most important datasets are found in biomedical and financial domains in the form of…

Machine Learning · Computer Science 2023-08-30 Gianluca Truda

Diffusion models have established themselves as state-of-the-art generative models across various data modalities, including images and videos, due to their ability to accurately approximate complex data distributions. Unlike traditional…

Machine Learning · Computer Science 2025-10-23 Daniel Wesego

Standard Latent Diffusion Models rely on a complex, three-part architecture consisting of a separate encoder, decoder, and diffusion network, which are trained in multiple stages. This modular design is computationally inefficient, leads to…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Xiyuan Wang , Muhan Zhang

In the medical domain, acquiring large datasets is challenging due to both accessibility issues and stringent privacy regulations. Consequently, data availability and privacy protection are major obstacles to applying machine learning in…

Image and Video Processing · Electrical Eng. & Systems 2025-07-02 Wenwu Tang , Khaled Seyam , Bin Yang

Combining discrete and continuous data is an important capability for generative models. We present Discrete Flow Models (DFMs), a new flow-based model of discrete data that provides the missing link in enabling flow-based generative models…

Machine Learning · Statistics 2024-06-07 Andrew Campbell , Jason Yim , Regina Barzilay , Tom Rainforth , Tommi Jaakkola

We introduce a framework for intrinsic latent diffusion models operating directly on the surfaces of 3D shapes, with the goal of synthesizing high-quality textures. Our approach is underpinned by two contributions: field latents, a latent…

Computer Vision and Pattern Recognition · Computer Science 2024-05-30 Thomas W. Mitchel , Carlos Esteves , Ameesh Makadia

Diffusion models have excelled at generative tasks for both continuous and token-based domains, but their application to discrete ordinal data remains underdeveloped. We present CountsDiff, a diffusion framework designed to natively model…

High-resolution image synthesis remains a core challenge in generative modeling, particularly in balancing computational efficiency with the preservation of fine-grained visual detail. We present Latent Wavelet Diffusion (LWD), a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-17 Luigi Sigillo , Shengfeng He , Danilo Comminiello

Dataset bias is a significant challenge in machine learning, where specific attributes, such as texture or color of the images are unintentionally learned resulting in detrimental performance. To address this, previous efforts have focused…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Donggeun Ko , Sangwoo Jo , Dongjun Lee , Namjun Park , Jaekwang Kim

Deep learning is widely applied in computer-aided pathological diagnosis, which alleviates the pathologist workload and provide timely clinical analysis. However, most models generally require large-scale annotated data for training, which…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Zeyu Liu , Tianyi Zhang , Yufang He , Yunlu Feng , Yu Zhao , Guanglei Zhang

Diffusion Generative Models (DGM) have rapidly surfaced as emerging topics in the field of computer vision, garnering significant interest across a wide array of deep learning applications. Despite their high computational demand, these…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Denisha Thakkar , Vincent Quoc-Huy Trinh , Sonal Varma , Samira Ebrahimi Kahou , Hassan Rivaz , Mahdi S. Hosseini

Recent advances in generative modeling -- particularly diffusion models and flow matching -- have achieved remarkable success in synthesizing discrete data such as images and videos. However, adapting these models to physical applications…

Machine Learning · Computer Science 2025-11-26 Sifan Wang , Zehao Dou , Siming Shan , Tong-Rui Liu , Lu Lu

Image synthesis has seen significant advancements with the advent of diffusion-based generative models like Denoising Diffusion Probabilistic Models (DDPM) and text-to-image diffusion models. Despite their efficacy, there is a dearth of…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Ruipeng Ma , Jinhao Duan , Fei Kong , Xiaoshuang Shi , Kaidi Xu

Dataset distillation seeks to condense datasets into smaller but highly representative synthetic samples. While diffusion models now lead all generative benchmarks, current distillation methods avoid them and rely instead on GANs or…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Brian B. Moser , Federico Raue , Sebastian Palacio , Stanislav Frolov , Andreas Dengel

Diffusion models (DMs) have achieved state-of-the-art results for image synthesis tasks as well as density estimation. Applied in the latent space of a powerful pretrained autoencoder (LDM), their immense computational requirements can be…

Computer Vision and Pattern Recognition · Computer Science 2022-10-21 Jeremias Traub

Diffusion models have achieved great success in modeling continuous data modalities such as images, audio, and video, but have seen limited use in discrete domains such as language. Recent attempts to adapt diffusion to language have…

Computation and Language · Computer Science 2023-11-08 Justin Lovelace , Varsha Kishore , Chao Wan , Eliot Shekhtman , Kilian Q. Weinberger