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Increasing the volume of training data can enable the auxiliary diagnostic algorithms for Autism Spectrum Disorder (ASD) to learn more accurate and stable models. However, due to the significant heterogeneity and domain shift in rs-fMRI…

Neurons and Cognition · Quantitative Biology 2025-07-11 Yiqian Luo , Qiurong Chen , Fali Li , Peng Xu , Yangsong Zhang

Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Early diagnosis and precise treatment are essential for ASD patients. Although researchers have built many analytical models, there has been limited progress in…

Neurons and Cognition · Quantitative Biology 2018-10-30 Juntang Zhuang , Nicha C. Dvornek , Xiaoxiao Li , Pamela Ventola , James S. Duncan

Resting-state fMRI is commonly used for diagnosing Autism Spectrum Disorder (ASD) by using network-based functional connectivity. It has been shown that ASD is associated with brain regions and their inter-connections. However,…

Neurons and Cognition · Quantitative Biology 2022-01-04 Ranjeet Ranjan Jha , Abhishek Bhardwaj , Devin Garg , Arnav Bhavsar , Aditya Nigam

Resting-state functional MRI (rs-fMRI) is a rich imaging modality that captures spontaneous brain activity patterns, revealing clues about the connectomic organization of the human brain. While many rs-fMRI studies have focused on static…

Machine Learning · Computer Science 2019-08-20 Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert R. Sabuncu

Autism spectrum disorder (ASD) is a highly disabling mental disease that brings significant impairments of social interaction ability to the patients, making early screening and intervention of ASD critical. With the development of the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Ruimin Ma , Ruitao Xie , Yanlin Wang , Jintao Meng , Yanjie Wei , Wenhui Xi , Yi Pan

Autism spectrum disorder (ASD) affects the brain connectivity at different levels. Nonetheless, non-invasively distinguishing such effects using magnetic resonance imaging (MRI) remains very challenging to machine learning diagnostic…

Machine Learning · Computer Science 2020-04-29 Ismail Bilgen , Goktug Guvercin , Islem Rekik

Diagnosis of Autism Spectrum Disorder (ASD) using clinical evaluation (cognitive tests) is challenging due to wide variations amongst individuals. Since no effective treatment exists, prompt and reliable ASD diagnosis can enable the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-11 Devika K , Venkata Ramana Murthy Oruganti , Dwarikanath Mahapatra , Ramanathan Subramanian

Functional magnetic resonance imaging (fMRI) has become instrumental in researching brain function. One application of fMRI is investigating potential neural features that distinguish people with autism spectrum disorder (ASD) from healthy…

Image and Video Processing · Electrical Eng. & Systems 2024-12-19 Sjir J. C. Schielen , Jesper Pilmeyer , Albert P. Aldenkamp , Danny Ruijters , Svitlana Zinger

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder impacting social and behavioral development. Resting-state fMRI, a non-invasive tool for capturing brain connectivity patterns, aids in early ASD diagnosis and differentiation…

Machine Learning · Computer Science 2025-02-27 Ziqiao Weng , Weidong Cai , Bo Zhou

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard…

Methodology · Statistics 2025-08-18 Wei Zhao , Brian J. Reich , Emily C. Hector

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that encompasses a wide variety of symptoms and degrees of impairment, which makes the diagnosis and treatment challenging. Functional magnetic resonance imaging (fMRI) has…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Yinchi Zhou , Peiyu Duan , Yuexi Du , Nicha C. Dvornek

Computer-aided early diagnosis of Alzheimer's disease (AD) and its prodromal form mild cognitive impairment (MCI) based on structure Magnetic Resonance Imaging (sMRI) has provided a cost-effective and objective way for early prevention and…

Image and Video Processing · Electrical Eng. & Systems 2021-11-16 Xin Zhang , Liangxiu Han , Wenyong Zhu , Liang Sun , Daoqiang Zhang

Single-subject mapping of resting-state brain functional activity to non-imaging phenotypes is a major goal of neuroimaging. The large majority of learning approaches applied today rely either on static representations or on short-term…

Machine Learning · Computer Science 2022-08-09 Ahmed El-Gazzar , Rajat Mani Thomas , Guido Van Wingen

Brain imaging classification is commonly approached from two perspectives: modeling the full image volume to capture global anatomical context, or constructing ROI-based graphs to encode localized and topological interactions. Although both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Wei Liang , Lifang He

While the prevalence of Autism Spectrum Disorder (ASD) is increasing, research continues in an effort to identify common etiological and pathophysiological bases. In this regard, modern machine learning and network science pave the way for…

Image and Video Processing · Electrical Eng. & Systems 2020-08-06 Sarah Itani , Dorina Thanou

Rare diseases represent the long tail of medical imaging, where AI models often fail due to the scarcity of representative training data. In clinical workflows, radiologists frequently consult case reports and literature when confronted…

Computation and Language · Computer Science 2025-11-10 Ha Young Kim , Jun Li , Ana Beatriz Solana , Carolin M. Pirkl , Benedikt Wiestler , Julia A. Schnabel , Cosmin I. Bercea

Autistic Spectrum Disorder (ASD) is a neurological disease characterized by difficulties with social interaction, communication, and repetitive activities. While its primary origin lies in genetics, early detection is crucial, and…

Machine Learning · Computer Science 2023-12-29 Rownak Ara Rasul , Promy Saha , Diponkor Bala , S M Rakib Ul Karim , Md. Ibrahim Abdullah , Bishwajit Saha

Purpose : Because functional MRI (fMRI) data sets are in general small, we sought a data efficient approach to resting state fMRI classification of autism spectrum disorder (ASD) versus neurotypical (NT) controls. We hypothesized that a…

Neurons and Cognition · Quantitative Biology 2022-06-23 Joseph Stember , Danielle Stember , Luca Pasquini , Jenabi Merhnaz , Andrei Holodny , Hrithwik Shalu

This work is an endeavor to develop a deep learning methodology for automated anatomical labeling of a given region of interest (ROI) in brain computed tomography (CT) scans. We combine both local and global context to obtain a…

Computer Vision and Pattern Recognition · Computer Science 2018-01-23 Srikrishna Varadarajan , Muktabh Mayank Srivastava , Monika Grewal , Pulkit Kumar