Deep reinforcement learning for fMRI prediction of Autism Spectrum Disorder
Abstract
Purpose : Because functional MRI (fMRI) data sets are in general small, we sought a data efficient approach to resting state fMRI classification of autism spectrum disorder (ASD) versus neurotypical (NT) controls. We hypothesized that a Deep Reinforcement Learning (DRL) classifier could learn effectively on a small fMRI training set. Methods : We trained a Deep Reinforcement Learning (DRL) classifier on 100 graph-label pairs from the Autism Brain Imaging Data Exchange (ABIDE) database. For comparison, we trained a Supervised Deep Learning (SDL) classifier on the same training set. Results : DRL significantly outperformed SDL, with a p-value of 2.4 x 10^(-7). DRL achieved superior results for a variety of classifier performance metrics, including an F1 score of 76, versus 67 for SDL. Whereas SDL quickly overfit the training data, DRL learned in a progressive manner that generalised to the separate testing set. Conclusion : DRL can learn to classify ASD versus NT in a data efficient manner, doing so for a small training set. Future work will involve optimizing the neural network for data efficiency and applying the approach to other fMRI data sets, namely for brain cancer patients.
Keywords
Cite
@article{arxiv.2206.11224,
title = {Deep reinforcement learning for fMRI prediction of Autism Spectrum Disorder},
author = {Joseph Stember and Danielle Stember and Luca Pasquini and Jenabi Merhnaz and Andrei Holodny and Hrithwik Shalu},
journal= {arXiv preprint arXiv:2206.11224},
year = {2022}
}
Comments
arXiv admin note: text overlap with arXiv:2106.09812