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Multi-omics data is increasingly being utilized to advance computational methods for cancer classification. However, multi-omics data integration poses significant challenges due to the high dimensionality, data complexity, and distinct…

Genomics · Quantitative Biology 2024-10-10 Fadi Alharbi , Aleksandar Vakanski , Boyu Zhang , Murtada K. Elbashir , Mohanad Mohammed

The integration of diverse clinical modalities such as medical imaging and the tabular data extracted from patients' Electronic Health Records (EHRs) is a crucial aspect of modern healthcare. Integrative analysis of multiple sources can…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Daniel Duenias , Brennan Nichyporuk , Tal Arbel , Tammy Riklin Raviv

Accurate cancer survival prediction requires integration of diverse data modalities that reflect the complex interplay between imaging, clinical parameters, and textual reports. However, existing multimodal approaches suffer from simplistic…

Machine Learning · Computer Science 2025-07-01 Aakash Tripathi , Asim Waqas , Matthew B. Schabath , Yasin Yilmaz , Ghulam Rasool

Early and accurate prediction of overall survival (OS) time can help to obtain better treatment planning for brain tumor patients. Although many OS time prediction methods have been developed and obtain promising results, there are still…

Image and Video Processing · Electrical Eng. & Systems 2020-07-16 Tao Zhou , Huazhu Fu , Yu Zhang , Changqing Zhang , Xiankai Lu , Jianbing Shen , Ling Shao

Recent advances in machine learning and prevalence of digital medical images have opened up an opportunity to address the challenging brain tumor segmentation (BTS) task by using deep convolutional neural networks. However, different from…

Image and Video Processing · Electrical Eng. & Systems 2022-01-10 Dingwen Zhang , Guohai Huang , Qiang Zhang , Jungong Han , Junwei Han , Yizhou Yu

Developing applicable clinical machine learning models is a difficult task when the data includes spatial information, for example, radiation dose distributions across adjacent organs at risk. We describe the co-design of a modeling system,…

The complementary information found in different modalities of patient data can aid in more accurate modelling of a patient's disease state and a better understanding of the underlying biological processes of a disease. However, the…

Machine Learning · Computer Science 2025-04-18 Annette Spooner , Mohammad Karimi Moridani , Azadeh Safarchi , Salim Maher , Fatemeh Vafaee , Amany Zekry , Arcot Sowmya

Multimodal MRI provides critical complementary information for accurate brain tumor segmentation. However, conventional methods struggle when certain modalities are missing due to issues such as image quality, protocol inconsistencies,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Runze Cheng , Xihang Qiu , Ming Li , Ye Zhang , Chun Li , Fei Yu

We consider the analysis of high dimensional data given in the form of a matrix with columns consisting of observations and rows consisting of features. Often the data is such that the observations do not reside on a regular grid, and the…

Machine Learning · Statistics 2017-08-22 Gal Mishne , Ronen Talmon , Israel Cohen , Ronald R. Coifman , Yuval Kluger

Background: Brain tumor segmentation has a significant impact on the diagnosis and treatment of brain tumors. Accurate brain tumor segmentation remains challenging due to their irregular shapes, vague boundaries, and high variability.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Zhanyuan Jia , Ni Yao , Danyang Sun , Chuang Han , Yanting Li , Jiaofen Nan , Fubao Zhu , Chen Zhao , Weihua Zhou

Microscopic examination of slides prepared from tissue samples is the primary tool for detecting and classifying cancerous lesions, a process that is time-consuming and requires the expertise of experienced pathologists. Recent advances in…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Saba Fatema , Brighton Nuwagira , Sayoni Chakraborty , Reyhan Gedik , Baris Coskunuzer

Brain tumors are a complex and potentially life-threatening medical condition that requires accurate diagnosis and timely treatment. In this paper, we present a machine learning-based system designed to assist healthcare professionals in…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Belal Badawy , Romario Sameh Samir , Youssef Tarek , Mohammed Ahmed , Rana Ibrahim , Manar Ahmed , Mohamed Hassan

The research on developing CNN-based fully-automated Brain-Tumor-Segmentation systems has been progressed rapidly. For the systems to be applicable in practice, a good The research on developing CNN-based fully-automated…

Image and Video Processing · Electrical Eng. & Systems 2022-05-04 Juncheng Tong , Chunyan Wang

Clinicians usually combine information from multiple sources to achieve the most accurate diagnosis, and this has sparked increasing interest in leveraging multimodal deep learning for diagnosis. However, in real clinical scenarios, due to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Kai Han , Chongwen Lyu , Lele Ma , Chengxuan Qian , Siqi Ma , Zheng Pang , Jun Chen , Zhe Liu

As machine learning (ML)-based decision support tools proliferate in clinical practice, understanding how clinicians integrate personalized ML predictions alongside randomized controlled trial (RCT) evidence is critical. We designed a…

Human-Computer Interaction · Computer Science 2026-05-19 Zeshan Hussain , Barbara D. Lam , Fernando A. Acosta-Perez , Irbaz Bin Riaz , Maia Jacobs , Andrew J. Yee , David Sontag

Robust and generalizable segmentation of brain tumors on multi-parametric magnetic resonance imaging (MRI) remains difficult because tumor types differ widely. The BraTS 2025 Lighthouse Challenge benchmarks segmentation methods on diverse…

The concept of personalised medicine in cancer therapy is becoming increasingly important. There already exist drugs administered specifically for patients with tumours presenting well-defined mutations. However, the field is still in its…

Biomolecules · Quantitative Biology 2024-08-26 Abbi Abdel-Rehim , Oghenejokpeme Orhobor , Gareth Griffiths , Larisa Soldatova , Ross D. King

This paper presents architecture for health care data warehouse specific to cancer diseases which could be used by executive managers, doctors, physicians and other health professionals to support the healthcare process. The data today…

Databases · Computer Science 2012-11-20 Osama El-Sayed Sheta , Ahmed Nour Eldeen

Purpose: Deep learning methods have shown promising results in the segmentation, and detection of diseases in medical images. However, most methods are trained and tested on data from a single source, modality, organ, or disease type,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Nchongmaje Ndipenocha , Alina Mirona , Kezhi Wanga , Yongmin Li

Pan-omics, pan-cancer analysis has advanced our understanding of the molecular heterogeneity of cancer, expanding what was known from single-cancer or single-omics studies. However, pan-cancer, pan-omics analyses have been limited in their…

Applications · Statistics 2021-03-02 Sarah Samorodnitsky , Katherine A. Hoadley , Eric F. Lock