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Reproduction numbers are widely used for the estimation and prediction of epidemic spreading processes over networks. However, conventional reproduction numbers of an overall network do not indicate where an epidemic is spreading.…

Systems and Control · Electrical Eng. & Systems 2025-06-23 Bo Chen , Baike She , Calvin Hawkins , Philip E. Paré , Matthew T. Hale

Accurate epidemic forecasting requires models that account for the layered and heterogeneous nature of real social interactions. The basic reproduction number $\mathcal R_0$ calculated from models that assume homogeneous mixing or…

Physics and Society · Physics 2025-10-15 Eric Alejandro Rozan , Mario Ignacio Simoy , Sebastian Bouzat , Marcelo Nestor Kuperman

The basic reproduction number ($R_0$) is an epidemiological metric that represents the average number of new infections caused by a single infectious individual in a completely susceptible population. The methodology for calculating this…

Algebraic Topology · Mathematics 2025-12-05 Trevor Reckell , Beckett Sterner , Petar Jevtić

The basic reproductive number -- $R_0$ -- is one of the most common and most commonly misapplied numbers in public health. Although often used to compare outbreaks and forecast pandemic risk, this single number belies the complexity that…

Populations and Evolution · Quantitative Biology 2020-04-15 Laurent Hébert-Dufresne , Benjamin M. Althouse , Samuel V. Scarpino , Antoine Allard

An important issue in theoretical epidemiology is the epidemic threshold phenomenon, which specify the conditions for an epidemic to grow or die out. In standard (mean-field-like) compartmental models the concept of the basic reproductive…

Biological Physics · Physics 2007-05-23 D. Alves , V. J. Haas , A. Caliri

Epidemic models are a valuable tool in the decision making process. Once a mathematical model for an epidemics has been established, the very next step is calculating a mathematical expression for the basic reproductive number, $R_0$, which…

Populations and Evolution · Quantitative Biology 2022-09-07 Carlos Hernandez-Suarez , Osval Montesinos Lopez

A social (sexual) network is modeled by an extension of the configuration model to the situation where edges have weights, e.g. reflecting the number of sex-contacts between the individuals. An epidemic model is defined on the network such…

Probability · Mathematics 2011-12-21 Tom Britton , David Lindenstrand

The basic reproduction number R0 -- the number of individuals directly infected by an infectious person in an otherwise susceptible population -- is arguably the most widely used estimator of how severe an epidemic outbreak can be. This…

Populations and Evolution · Quantitative Biology 2016-03-18 Petter Holme , Naoki Masuda

Reproduction numbers are widely used for the estimation and prediction of epidemic spreading processes over networks. However, reproduction numbers do not enable estimation and prediction in individual communities within networks, and they…

Systems and Control · Electrical Eng. & Systems 2025-06-23 Baike She , Philip E. Paré , Matthew Hale

Epidemiologic studies of infectious diseases often rely on models of contact networks to capture the complex interactions that govern disease spread, and ongoing projects aim to vastly increase the scale at which such data can be collected.…

Cryptography and Security · Computer Science 2026-04-10 Shlomi Hod , Debanuj Nayak , Jason R. Gantenberg , Iden Kalemaj , Thomas A. Trikalinos , Adam Smith

Designing effective strategies for controlling epidemic spread by vaccination is an important question in epidemiology, especially in the early stages when vaccines are limited. This is a challenging question when the contact network is…

Data Structures and Algorithms · Computer Science 2025-06-03 Dung Nguyen , Aravind Srinivasan , Renata Valieva , Anil Vullikanti , Jiayi Wu

The basic reproduction number $R_0$ is a fundamental quantity in epidemiological modeling, reflecting the typical number of secondary infections that arise from a single infected individual. While $R_0$ is widely known to scientists,…

Optimization and Control · Mathematics 2022-09-05 Kevin D. Smith , Francesco Bullo

Differential privacy has been used to privately calculate numerous network properties, but existing approaches often require the development of a new privacy mechanism for each property of interest. Therefore, we present a framework for…

Optimization and Control · Mathematics 2025-10-03 Huaiyuan Rao , Calvin Hawkins , Alexander Benvenuti , Matthew Hale

In this paper, we provide a straightforward approach to defining and deriving the key epidemiological quantity, the basic reproduction number, $R_0$, for Markovian epidemics in structured populations. The methodology derived is applicable…

Populations and Evolution · Quantitative Biology 2019-03-26 Peter Neal , Thitiya Theparod

We propose a novel approach to approximate the basic reproduction number $R_0$ as spectral radius of the Next-Generation Operator in time-periodic population models by characterizing the latter via evolution semigroups. Once birth/infection…

Numerical Analysis · Mathematics 2025-09-03 Dimitri Breda , Simone De Reggi , Jordi Ripoll

A key parameter in models for the spread of infectious diseases is the basic reproduction number $R_0$, which is the expected number of secondary cases a typical infected primary case infects during its infectious period in a large mostly…

Populations and Evolution · Quantitative Biology 2017-09-05 Kristoffer Spricer , Pieter Trapman

The basic reproduction number, $R_0$ is an important and widely used concept in the study of infectious diseases. We briefly review the recent trend of calculating the average of various $R_0$ estimates in systematic reviews aimed at…

Populations and Evolution · Quantitative Biology 2021-12-13 Pratyush K. Kollepara , Joel C. Miller

The basic reproduction number, $R_0$, is a well-known quantifier of epidemic spread. However, a class of existing methods for estimating $R_0$ from incidence data early in the epidemic can lead to an over-estimation of this quantity. In…

Populations and Evolution · Quantitative Biology 2024-03-27 Wajid Ali , Christopher E. Overton , Robert R. Wilkinson , Kieran J. Sharkey

When an infectious disease strikes a population, the number of newly reported cases is often the only available information that one can obtain during early stages of the outbreak. An important goal of early outbreak analysis is to obtain a…

Quantitative Methods · Quantitative Biology 2013-05-30 Bahman Davoudi , Babak Pourbohloul , Joel Miller , Rafael Meza , Lauren Ancel Meyers , David J. D. Earn

In this paper we consider epidemic models of directly transmissible SIR (susceptible $\to$ infective $\to$ recovered) and SEIR (with an additional latent class) infections in fully-susceptible populations with a social structure, consisting…

Populations and Evolution · Quantitative Biology 2015-12-11 Frank Ball , Lorenzo Pellis , Pieter Trapman
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