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We address the challenge of optimizing the capacity-achieving input distribution for a multinomial channel under the constraint of limited input support size, which is a crucial aspect in the design of DNA storage systems. We propose an…

Information Theory · Computer Science 2025-01-28 Adir Kobovich , Eitan Yaakobi , Nir Weinberger

DNA data storage offers a high-density, long-term alternative to traditional storage systems, addressing the exponential growth of digital data. Composite DNA extends this paradigm by leveraging mixtures of nucleotides to increase storage…

Information Theory · Computer Science 2026-02-13 Busra Tegin , Tolga M Duman

Due to the redundant nature of DNA synthesis and sequencing technologies, a basic model for a DNA storage system is a multi-draw "shuffling-sampling" channel. In this model, a random number of noisy copies of each sequence is observed at…

Information Theory · Computer Science 2021-12-06 Kel Levick , Reinhard Heckel , Ilan Shomorony

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

Information Theory · Computer Science 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

Technologies for sequencing (reading) and synthesizing (writing) DNA have progressed on a Moore's law-like trajectory over the last three decades. This has motivated the idea of using DNA for data storage. Theoretically, DNA-based storage…

Emerging Technologies · Computer Science 2023-07-07 Ajay Manicka , Andrew Stephan , Sriram Chari , Gemma Mendonsa , Peyton Okubo , John Stolzberg-Schray , Anil Reddy , Marc Riedel

We present a distributed generic algorithm called DAMS dedicated to adaptive optimization in distributed environments. Given a set of metaheuristic, the goal of DAMS is to coordinate their local execution on distributed nodes in order to…

Neural and Evolutionary Computing · Computer Science 2012-07-19 Bilel Derbel , Sébastien Verel

To increase the information capacity of DNA storage, composite DNA letters were introduced. We propose a novel channel model for composite DNA in which composite sequences are decomposed into ordered standard non-composite sequences. The…

Information Theory · Computer Science 2025-10-31 Besart Dollma , Ohad Elishco , Eitan Yaakobi

DNA exhibits remarkable potential as a data storage solution due to its impressive storage density and long-term stability, stemming from its inherent biomolecular structure. However, developing this novel medium comes with its own set of…

Image and Video Processing · Electrical Eng. & Systems 2023-09-14 Trung Hieu Le , Xavier Pic , Jeremy Mateos , Marc Antonini

DNA, with remarkable properties of high density, durability, and replicability, is one of the most appealing storage media. Emerging DNA storage technologies use composite DNA letters, where information is represented by probability…

Information Theory · Computer Science 2025-03-26 Wenkai Zhang , Zhiying Wang

With the rapid increase of available digital data, DNA storage is identified as a storage media with high density and capability of long-term preservation, especially for archival storage systems. However, the encoding density (i.e., how…

Emerging Technologies · Computer Science 2021-08-26 Bingzhe Li , Li Ou , David Du

This paper proposes a new algorithm, referred to as GMAB, that combines concepts from the reinforcement learning domain of multi-armed bandits and random search strategies from the domain of genetic algorithms to solve discrete stochastic…

Neural and Evolutionary Computing · Computer Science 2023-02-16 Deniz Preil , Michael Krapp

We consider error-correcting coding for DNA-based storage. We model the DNA storage channel as a multi-draw IDS channel where the input data is chunked into $M$ short DNA strands, which are copied a random number of times, and the channel…

Information Theory · Computer Science 2023-06-22 Lorenz Welter , Issam Maarouf , Andreas Lenz , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

The capacity and capacity-achieving distribution for intensity-modulation and direct-detection (IM-DD) fiber-optic channels is theoretically investigated. Different from coherent fiber-optic channels, we indicate that the capacity-achieving…

Signal Processing · Electrical Eng. & Systems 2023-02-24 Dongdong Zou , Wei Wang , Sui Qi , Fan Li , Zhaohui Li

In this paper, we study achievable rates of concatenated coding schemes over a deoxyribonucleic acid (DNA) storage channel. Our channel model incorporates the main features of DNA-based data storage. First, information is stored on many,…

Information Theory · Computer Science 2020-05-04 Andreas Lenz , Lorenz Welter , Sven Puchinger

We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic

Modern optimization problems in scientific and engineering domains often rely on expensive black-box evaluations, such as those arising in physical simulations or deep learning pipelines, where gradient information is unavailable or…

Computation · Statistics 2026-01-05 Foo Hui-Mean , Yuan-chin Ivan Chang

Calculating the capacity (with or without feedback) of channels with memory and continuous alphabets is a challenging task. It requires optimizing the directed information (DI) rate over all channel input distributions. The objective is a…

Information Theory · Computer Science 2020-05-19 Ziv Aharoni , Dor Tsur , Ziv Goldfeld , Haim Henry Permuter

In modern large-scale machine learning applications, the training data are often partitioned and stored on multiple machines. It is customary to employ the "data parallelism" approach, where the aggregated training loss is minimized without…

Machine Learning · Computer Science 2017-08-28 Shun Zheng , Jialei Wang , Fen Xia , Wei Xu , Tong Zhang

The DNA storage channel is considered, in which the $M$ Deoxyribonucleic acid (DNA) molecules comprising each codeword are stored without order, sampled $N$ times with replacement, and then sequenced over a discrete memoryless channel. For…

Information Theory · Computer Science 2022-02-15 Nir Weinberger , Neri Merhav

Deep Neural Networks (DNNs) have recently been achieving state-of-the-art performance on a variety of computer vision related tasks. However, their computational cost limits their ability to be implemented in embedded systems with…

Computer Vision and Pattern Recognition · Computer Science 2020-08-26 Laurent Dillard , Yosuke Shinya , Taiji Suzuki
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