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The European Medicines Agency has in recent years allowed licensing of new pharmaceuticals at an earlier stage in the clinical trial process. When trial evidence is obtained at an early stage, the events of interest, such as disease…

Unit testing represents the foundational basis of the software testing pyramid, beneath integration and end-to-end testing. Automated software testing researchers have proposed a variety of techniques to assist developers in this…

Software Engineering · Computer Science 2022-03-25 Michele Tufano , Dawn Drain , Alexey Svyatkovskiy , Neel Sundaresan

GPUs are a key enabler of the revolution in machine learning and high performance computing, functioning as de facto co-processors to accelerate large-scale computation. As the programming stack and tool support have matured, GPUs have also…

Neural and Evolutionary Computing · Computer Science 2020-04-29 Jhe-Yu Liou , Xiaodong Wang , Stephanie Forrest , Carole-Jean Wu

Accurate segmentation of nodules in both 2D breast ultrasound (BUS) and 3D automated breast ultrasound (ABUS) is crucial for clinical diagnosis and treatment planning. Therefore, developing an automated system for nodule segmentation can…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Yuhao Huang , Ao Chang , Haoran Dou , Xing Tao , Xinrui Zhou , Yan Cao , Ruobing Huang , Alejandro F Frangi , Lingyun Bao , Xin Yang , Dong Ni

Retrieval-augmented generation (RAG) grounds large language models (LLMs) in up-to-date external evidence, yet existing multi-hop RAG pipelines still issue redundant subqueries, explore too shallowly, or wander through overly long search…

Computation and Language · Computer Science 2025-05-26 Yuelyu Ji , Rui Meng , Zhuochun Li , Daqing He

We propose CURE, a novel reinforcement learning framework with a dedicated reward design that co-evolves coding and unit test generation capabilities based on their interaction outcomes, without any ground-truth code as supervision. This…

Computation and Language · Computer Science 2025-09-26 Yinjie Wang , Ling Yang , Ye Tian , Ke Shen , Mengdi Wang

We present a novel classification-based algorithm called GeneClass for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple organisms such as Saccharomyces cerevisiae, we can learn a…

Quantitative Methods · Quantitative Biology 2007-05-23 Manuel Middendorf , Anshul Kundaje , Chris Wiggins , Yoav Freund , Christina Leslie

Background: The development of classification methods for personalized medicine is highly dependent on the identification of predictive genetic markers. In survival analysis it is often necessary to discriminate between influential and…

Methodology · Statistics 2018-02-27 Thomas Welchowski , Verena Zuber , Matthias Schmid

Prostate cancer is a dominant health concern calling for advanced diagnostic tools. Utilizing digital pathology and artificial intelligence, this study explores the potential of 11 deep neural network architectures for automated Gleason…

Entity resolution targets at identifying records that represent the same real-world entity from one or more datasets. A major challenge in learning-based entity resolution is how to reduce the label cost for training. Due to the quadratic…

Machine Learning · Computer Science 2020-12-21 Jingyu Shao , Qing Wang , Asiri Wijesinghe , Erhard Rahm

CUDA kernel optimization has become a critical bottleneck for AI performance, as deep learning training and inference efficiency directly depends on highly optimized GPU kernels. Despite the promise of Large Language Models (LLMs) for…

Machine Learning · Computer Science 2025-10-07 Ping Guo , Chenyu Zhu , Siyuan Chen , Fei Liu , Xi Lin , Zhichao Lu , Qingfu Zhang

Automatic scoring engines have been used for scoring approximately fifteen million test-takers in just the last three years. This number is increasing further due to COVID-19 and the associated automation of education and testing. Despite…

Computation and Language · Computer Science 2021-11-16 Anubha Kabra , Mehar Bhatia , Yaman Kumar , Junyi Jessy Li , Rajiv Ratn Shah

Evolution-based neural architecture search requires high computational resources, resulting in long search time. In this work, we propose a framework of applying the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) to the neural…

Neural and Evolutionary Computing · Computer Science 2021-07-16 Nilotpal Sinha , Kuan-Wen Chen

The overall aim of the software industry is to ensure delivery of high quality software to the end user. To ensure high quality software, it is required to test software. Testing ensures that software meets user specifications and…

Software Engineering · Computer Science 2014-11-06 Chayanika Sharma , Sangeeta Sabharwal , Ritu Sibal

[Context:] Model-based testing is an instrument for automated generation of test cases. It requires identifying requirements in documents, understanding them syntactically and semantically, and then translating them into a test model. One…

Software Engineering · Computer Science 2019-08-26 Jannik Fischbach , Maximilian Junker , Andreas Vogelsang , Dietmar Freudenstein

Breast cancer is one of the most threatening diseases in women's life; thus, the early and accurate diagnosis plays a key role in reducing the risk of death in a patient's life. Mammography stands as the reference technique for breast…

Machine Learning · Computer Science 2023-05-05 Juan Zuluaga-Gomez

Due to its importance and widespread use in industry, automated testing of REST APIs has attracted major interest from the research community in the last few years. However, most of the work in the literature has been focused on black-box…

Software Engineering · Computer Science 2023-09-18 Andrea Arcuri , Man Zhang , Juan Pablo Galeotti

The Abstraction and Reasoning Corpus remains one of the most compelling and challenging benchmarks for tracking progress toward achieving Artificial General Intelligence. In contrast to other evaluation datasets designed to assess an…

Artificial Intelligence · Computer Science 2025-11-05 Michael D. Moffitt

The efficient exploration of chemical space remains a central challenge, as many generative models still produce unstable or non-synthesizable compounds. To address these limitations, we present EvoMol-RL, a significant extension of the…

Machine Learning · Computer Science 2025-10-02 Gaelle Milon-Harnois , Chaimaa Touhami , Nicolas Gutowski , Benoit Da Mota , Thomas Cauchy

The most common method to auto-grade a student's submission in a CS1 or a CS2 course is to run it against a pre-defined test suite and compare the results against reference results. However, this technique cannot be used if the correctness…

Artificial Intelligence · Computer Science 2024-10-22 Aaryen Mehta , Gagan Aryan