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In ophthalmological imaging, multiple imaging systems, such as color fundus, infrared, fluorescein angiography, optical coherence tomography (OCT) or OCT angiography, are often involved to make a diagnosis of retinal disease. Multi-modal…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Aline Sindel , Bettina Hohberger , Andreas Maier , Vincent Christlein

Vascular structures in the retina contain important information for the detection and analysis of ocular diseases, including age-related macular degeneration, diabetic retinopathy and glaucoma. Commonly used modalities in diagnosis of these…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Erick O. Rodrigues , Aura Conci , Panos Liatsis

Ophthalmological imaging utilizes different imaging systems, such as color fundus, infrared, fluorescein angiography, optical coherence tomography (OCT) or OCT angiography. Multiple images with different modalities or acquisition times are…

Image and Video Processing · Electrical Eng. & Systems 2022-01-10 Aline Sindel , Bettina Hohberger , Sebastian Fassihi Dehcordi , Christian Mardin , Robert Lämmer , Andreas Maier , Vincent Christlein

Optical coherence tomography angiography (OCTA) is a novel noninvasive imaging modality for visualization of retinal blood flow in the human retina. Using specific OCTA imaging biomarkers for the identification of pathologies, automated…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Anna Breger , Felix Goldbach , Bianca S. Gerendas , Ursula Schmidt-Erfurth , Martin Ehler

Segmenting the retinal vasculature entails a trade-off between how much of the overall vascular structure we identify vs. how precisely we segment individual vessels. In particular, state-of-the-art methods tend to under-segment faint…

Computer Vision and Pattern Recognition · Computer Science 2019-03-28 Aashis Khanal , Rolando Estrada

Retinal vessel segmentation is generally grounded in image-based datasets collected with bench-top devices. The static images naturally lose the dynamic characteristics of retina fluctuation, resulting in diminished dataset richness, and…

Optical Coherence Tomography Angiography (OCT-A) is a non-invasive imaging technique, and has been increasingly used to image the retinal vasculature at capillary level resolution. However, automated segmentation of retinal vessels in OCT-A…

Image and Video Processing · Electrical Eng. & Systems 2020-12-10 Yuhui Ma , Huaying Hao , Huazhu Fu , Jiong Zhang , Jianlong Yang , Jiang Liu , Yalin Zheng , Yitian Zhao

Purpose: We proposed a deep convolutional neural network (CNN), named Retinal Fluid Segmentation Network (ReF-Net) to segment volumetric retinal fluid on optical coherence tomography (OCT) volume. Methods: 3 x 3-mm OCT scans were acquired…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Yukun Guo , Tristan T. Hormel , Honglian Xiong , Jie Wang , Thomas S. Hwang , Yali Jia

Optical coherence tomography angiography (OCTA) is an imaging technique that allows for non-invasive investigation of the microvasculature in the retina. OCTA uses laser light reflectance to measure moving blood cells. Hereby, it visualizes…

Tissues and Organs · Quantitative Biology 2020-02-11 Astrid M. E. Engberg , Vedrana A. Dahl , Anders B. Dahl

Topological and geometrical analysis of retinal blood vessel is a cost-effective way for early detection of many common diseases. Meanwhile, automated vessel segmentation and vascular tree analysis are still lacking in terms of…

Image and Video Processing · Electrical Eng. & Systems 2021-11-24 Xingzheng Lyu , Li Cheng , Sanyuan Zhang

Age-related macular degeneration (AMD) is characterized by early micro-vascular alterations that can be captured non-invasively using optical coherence tomography angiography (OCTA), yet most deep learning (DL) models rely on global…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Margalit G. Mitzner , Moinak Bhattacharya , Zhilin Zou , Chao Chen , Prateek Prasanna

Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality that allows micron-level resolution to visualize the retinal microvasculature. The retinal vessel segmentation in OCTA images is still an open problem,…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Mingchao Li , Yerui Chen , Weiwei Zhang , Qiang Chen

The retinal vasculature provides important clues in the diagnosis and monitoring of systemic diseases including hypertension and diabetes. The microvascular system is of primary involvement in such conditions, and the retina is the only…

Image and Video Processing · Electrical Eng. & Systems 2022-03-29 Ali Hatamizadeh , Hamid Hosseini , Niraj Patel , Jinseo Choi , Cameron C. Pole , Cory M. Hoeferlin , Steven D. Schwartz , Demetri Terzopoulos

Automated detection of retinal structures, such as retinal vessels (RV), the foveal avascular zone (FAZ), and retinal vascular junctions (RVJ), are of great importance for understanding diseases of the eye and clinical decision-making. In…

Image and Video Processing · Electrical Eng. & Systems 2022-08-24 Jinkui Hao , Ting Shen , Xueli Zhu , Yonghuai Liu , Ardhendu Behera , Dan Zhang , Bang Chen , Jiang Liu , Jiong Zhang , Yitian Zhao

Optical coherence tomography angiography (OCTA) is a novel imaging modality that has been widely utilized in ophthalmology and neuroscience studies to observe retinal vessels and microvascular systems. However, publicly available OCTA…

Image and Video Processing · Electrical Eng. & Systems 2022-12-27 Mingchao Li , Kun Huang , Qiuzhuo Xu , Jiadong Yang , Yuhan Zhang , Zexuan Ji , Keren Xie , Songtao Yuan , Qinghuai Liu , Qiang Chen

The utilisation of deep learning segmentation algorithms that learn complex organs and tissue patterns and extract essential regions of interest from the noisy background to improve the visual ability for medical image diagnosis has…

Computer Vision and Pattern Recognition · Computer Science 2023-11-03 Yanming Guo

We identify two major limitations in the existing studies on retinal vessel segmentation: (1) Most existing works are restricted to one modality, i.e., the Color Fundus (CF). However, multi-modality retinal images are used every day in the…

Image and Video Processing · Electrical Eng. & Systems 2026-01-01 Bo Wen , Anna Heinke , Akshay Agnihotri , Dirk-Uwe Bartsch , William Freeman , Truong Nguyen , Cheolhong An

Vessel segmentation of retinal images is a key diagnostic capability in ophthalmology. This problem faces several challenges including low contrast, variable vessel size and thickness, and presence of interfering pathology such as…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Venkateswararao Cherukuri , Vijay Kumar BG , Raja Bala , Vishal Monga

Retinal vessel segmentation is crucial for intelligent ophthalmic diagnosis, yet it faces three major challenges: insufficient multi-scale feature fusion, disruption of contextual continuity, and noise interference. This study proposes a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Xinran Xu , Yuliang Ma , Sifu Cai , Ming Meng , Qiang Lv , Ruoyan Shi

Structural changes in retinal blood vessels are critical biomarkers for the onset and progression of glaucoma and other ocular diseases. However, current vessel segmentation approaches largely rely on supervised learning and extensive…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Cheng Huang , Weizheng Xie , Fan Gao , Yutong Liu , Ruoling Wu , Zeyu Han , Jingxi Qiu , Xiangxiang Wang , Zhenglin Yang , Hao Wang , Yongbin Yu
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