Related papers: Simulation-Based Design of Bicuspidization of the …
The predictive accuracy of wall-modeled large eddy simulation is studied by systematic simulation campaigns of turbulent channel flow. The effect of wall model, grid resolution and anisotropy, numerical convective scheme and subgrid-scale…
We introduce an innovative lumped-parameter model of the aortic valve, designed to efficiently simulate the impact of valve dynamics on blood flow. Our reduced model includes the elastic effects associated with the leaflets' curvature and…
Computer simulation of "virtual interventions" may inform optimal valve repair for a given patient prior to intervention. However, the paucity of noninvasive methods to determine in vivo mechanical parameters of valves limits the accuracy…
Accurate prediction of aortic expansion in uncomplicated type B aortic dissection (TBAD) can help identify patients who may benefit from timely thoracic endovascular aortic repair. This study investigates associations between biomechanical…
Abdominal aortic aneurysms (AAAs) are progressive focal dilatations of the abdominal aorta. AAAs may rupture, with a survival rate of only 20\%. Current clinical guidelines recommend elective surgical repair when the maximum AAA diameter…
Intracranial aneurysms remain a major cause of neurological morbidity and mortality worldwide, where rupture risk is tightly coupled to local hemodynamics particularly wall shear stress and oscillatory shear index. Conventional…
In this paper, wall-modeled large-eddy simulation (WMLES) is carried out with Ffowcs-Williams and Hawkings (FW-H) acoustic analogy to investigate the turbulent flow and hydrodynamic noise of an axisymmetric body of revolution. We first…
Understanding the complex interplay between morphologic and hemodynamic features in aortic dissection is critical for risk stratification and for the development of individualized therapy. This work evaluates the effects of entry and exit…
We report computational results of blood flow through a model of the human aortic arch and a vessel of actual diameter and length. On the top of the aortic arch the branching of the %%three arteries are included: the subclavian and jugular.…
We employ micro-particle image velocimetry ($\mu$-PIV) to investigate laminar micro-flows in hydrophobic microstructured channels, in particular the slip length. These microchannels consist of longitudinal micro-grooves, which can trap air…
Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid aortic valves, alter leaflet loading, increase strain, and accelerate disease progression.…
Although research studies in pneumatic soft robots develop rapidly, most pneumatic actuators are still controlled by rigid valves and conventional electronics. The existence of these rigid, electronic components sacrifices the compliance…
It has long been recognized that aortic root elasticity helps to ensure efficient aortic valve closure, but our understanding of the functional importance of the elasticity and geometry of the aortic root continues to evolve as increasingly…
We investigate the stability of the deformation modeled by the opening angle method, often used to give a measure of residual stresses in arteries and other biological soft tubular structures. Specifically, we study the influence of…
Objective: ascending aortic aneurysm growth prediction is still challenging in clinics. In this study, we evaluate and compare the ability of local and global shape features to predict ascending aortic aneurysm growth. Material and methods:…
Coronary heart disease (CHD) remains a top reason of mortality worldwide. This study introduces a novel approach by integrating patient-specific Multi-slice CT scans into CAD models and employing a one-dimensional numerical framework to…
This study presents wall-resolved large-eddy simulations (WRLES) of a high-lift airfoil, based on high-order flux reconstruction (FR) commercial software Dimaxer, which runs on consumer level GPUs. A series of independence tests are…
The treatment of intracranial aneurysms (IA) relies on angiography guidance using biplane views. However, accurate flow estimation and device sizing for treatment are often compromised by vessel overlap and foreshortening, which can obscure…
Each year, approximately 300,000 heart valve repair or replacement procedures are performed worldwide, including approximately 70,000 aortic valve replacement surgeries in the United States alone. This paper describes progress in…
We present an aeroacoustic shape optimization framework that relies on high-order Flux Reconstruction (FR), the gradient-free Mesh Adaptive Direct Search (MADS) optimization algorithm, and Large Eddy Simulation (LES). Our parallel…