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Access to large-scale high-quality healthcare databases is key to accelerate medical research and make insightful discoveries about diseases. However, access to such data is often limited by patient privacy concerns, data sharing…

Data synthesis has been advocated as an important approach for utilizing data while protecting data privacy. In recent years, a plethora of tabular data synthesis algorithms (i.e., synthesizers) have been proposed. Some synthesizers satisfy…

Cryptography and Security · Computer Science 2025-09-09 Yuntao Du , Ninghui Li

Artificial intelligence (AI) has the potential to transform healthcare, but it requires access to health data. Synthetic data that is generated through machine learning models trained on real data, offers a way to share data while…

Computers and Society · Computer Science 2025-08-13 Vibeke Binz Vallevik , Anne Kjersti C. Befring , Severin Elvatun , Jan Franz Nygaard

Introduction: The amount of data generated by original research is growing exponentially. Publicly releasing them is recommended to comply with the Open Science principles. However, data collected from human participants cannot be released…

Machine Learning · Statistics 2023-10-11 Rémy Chapelle , Bruno Falissard

Training generative machine learning models to produce synthetic tabular data has become a popular approach for enhancing privacy in data sharing. As this typically involves processing sensitive personal information, releasing either the…

Cryptography and Security · Computer Science 2026-02-02 Georgi Ganev , Emiliano De Cristofaro

Generative models have been found effective for data synthesis due to their ability to capture complex underlying data distributions. The quality of generated data from these models is commonly evaluated by visual inspection for image…

Machine Learning · Computer Science 2022-10-18 Emily Muller , Xu Zheng , Jer Hayes

The scarcity of high-quality annotated medical data, particularly in mental health, poses a significant bottleneck for training robust machine learning models. Privacy regulations restrict data sharing, making synthetic data generation a…

This paper presents a comprehensive systematic review of generative models (GANs, VAEs, DMs, and LLMs) used to synthesize various medical data types, including imaging (dermoscopic, mammographic, ultrasound, CT, MRI, and X-ray), text,…

Data privacy is a critical challenge in modern medical workflows as the adoption of electronic patient records has grown rapidly. Stringent data protection regulations limit access to clinical records for training and integrating machine…

In the current data driven era, synthetic data, artificially generated data that resembles the characteristics of real world data without containing actual personal information, is gaining prominence. This is due to its potential to…

Machine Learning · Computer Science 2023-09-06 Tshilidzi Marwala , Eleonore Fournier-Tombs , Serge Stinckwich

Enhancing reproducibility and data accessibility is essential to scientific research. However, ensuring data privacy while achieving these goals is challenging, especially in the medical field, where sensitive data are often commonplace.…

Methodology · Statistics 2025-09-24 Marta Cipriani , Lorenzo Di Rocco , Maria Puopolo , Marco Alfò

Synthetic data is often positioned as a solution to replace sensitive fixed-size datasets with a source of unlimited matching data, freed from privacy concerns. There has been much progress in synthetic data generation over the last decade,…

Machine Learning · Computer Science 2025-06-09 Graham Cormode , Samuel Maddock , Enayat Ullah , Shripad Gade

Access to real-world medical data is often restricted due to privacy regulations, posing a significant barrier to the advancement of healthcare research. Synthetic data offers a promising alternative; however, generating realistic,…

Artificial Intelligence · Computer Science 2025-08-13 Arshia Ilaty , Hossein Shirazi , Hajar Homayouni

In today's business landscape, organizations need to find the right balance between using their customers' data ethically to power AI solutions and being compliant regarding data privacy and data usage regulations. In this paper, we discuss…

Computers and Society · Computer Science 2025-03-18 Aditi Godbole

Data stewards seeking to provide access to large-scale social science data face a difficult challenge. They have to share data in ways that protect privacy and confidentiality, are informative for many analyses and purposes, and are…

To make medical datasets accessible without sharing sensitive patient information, we introduce a novel end-to-end approach for generative de-identification of dynamic medical imaging data. Until now, generative methods have faced…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Hadrien Reynaud , Qingjie Meng , Mischa Dombrowski , Arijit Ghosh , Thomas Day , Alberto Gomez , Paul Leeson , Bernhard Kainz

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

Advances in generative models have transformed the field of synthetic image generation for privacy-preserving data synthesis (PPDS). However, the field lacks a comprehensive survey and comparison of synthetic image generation methods across…

Cryptography and Security · Computer Science 2025-06-27 Yunsung Chung , Yunbei Zhang , Nassir Marrouche , Jihun Hamm

The generation of privacy-preserving synthetic datasets is a promising avenue for overcoming data scarcity in medical AI research. Post-hoc privacy filtering techniques, designed to remove samples containing personally identifiable…

Machine Learning · Computer Science 2025-10-03 Adil Koeken , Alexander Ziller , Moritz Knolle , Daniel Rueckert

Recognizing pain in video is crucial for improving patient-computer interaction systems, yet traditional data collection in this domain raises significant ethical and logistical challenges. This study introduces a novel approach that…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Jonas Nasimzada , Jens Kleesiek , Ken Herrmann , Alina Roitberg , Constantin Seibold