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Access to individual-level health data is essential for gaining new insights and advancing science. In particular, modern methods based on artificial intelligence rely on the availability of and access to large datasets. In the health…

Synthetic data generation is a powerful tool for privacy protection when considering public release of record-level data files. Initially proposed about three decades ago, it has generated significant research and application interest. To…

Methodology · Statistics 2023-08-03 Jingchen Hu , Claire McKay Bowen

Recent advances in deep generative models have greatly expanded the potential to create realistic synthetic health datasets. These synthetic datasets aim to preserve the characteristics, patterns, and overall scientific conclusions derived…

Machine Learning · Computer Science 2024-07-04 Jennifer A Bartell , Sander Boisen Valentin , Anders Krogh , Henning Langberg , Martin Bøgsted

Privacy-preserving synthetic data offers a promising solution to harness segregated data in high-stakes domains where information is compartmentalized for regulatory, privacy, or institutional reasons. This survey provides a comprehensive…

Cryptography and Security · Computer Science 2025-03-28 Viktor Schlegel , Anil A Bharath , Zilong Zhao , Kevin Yee

The digitization of medical records ushered in a new era of big data to clinical science, and with it the possibility that data could be shared, to multiply insights beyond what investigators could abstract from paper records. The need to…

Machine Learning · Computer Science 2021-06-03 Ofer Mendelevitch , Michael D. Lesh

The increasing use of synthetic data generated by Large Language Models (LLMs) presents both opportunities and challenges in data-driven applications. While synthetic data provides a cost-effective, scalable alternative to real-world data…

Computation and Language · Computer Science 2025-07-25 Tevin Atwal , Chan Nam Tieu , Yefeng Yuan , Zhan Shi , Yuhong Liu , Liang Cheng

Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating…

Machine Learning · Computer Science 2019-11-28 Saloni Dash , Ritik Dutta , Isabelle Guyon , Adrien Pavao , Andrew Yale , Kristin P. Bennett

The availability of genomic data is essential to progress in biomedical research, personalized medicine, etc. However, its extreme sensitivity makes it problematic, if not outright impossible, to publish or share it. As a result, several…

Genomics · Quantitative Biology 2022-01-19 Bristena Oprisanu , Georgi Ganev , Emiliano De Cristofaro

Machine learning heavily relies on data, but real-world applications often encounter various data-related issues. These include data of poor quality, insufficient data points leading to under-fitting of machine learning models, and…

Machine Learning · Computer Science 2025-04-07 Yingzhou Lu , Lulu Chen , Yuanyuan Zhang , Minjie Shen , Huazheng Wang , Xiao Wang , Capucine van Rechem , Tianfan Fu , Wenqi Wei

The widespread adoption of electronic health records and digital healthcare data has created a demand for data-driven insights to enhance patient outcomes, diagnostics, and treatments. However, using real patient data presents privacy and…

Machine Learning · Computer Science 2023-11-15 Aryan Jadon , Shashank Kumar

Motivated by privacy concerns in long-term longitudinal studies in medical and social science research, we study the problem of continually releasing differentially private synthetic data from longitudinal data collections. We introduce a…

Data Structures and Algorithms · Computer Science 2024-05-28 Mark Bun , Marco Gaboardi , Marcel Neunhoeffer , Wanrong Zhang

Generating synthetic tabular health data is challenging, and evaluating their quality is equally, if not more, complex. This systematic review highlights the critical importance of rigorous evaluation of synthetic health data to ensure…

Machine Learning · Computer Science 2026-05-15 Nazia Nafis , Inaki Esnaola , Alvaro Martinez-Perez , Maria-Cruz Villa-Uriol , Venet Osmani

Synthetic data has gained significant momentum thanks to sophisticated machine learning tools that enable the synthesis of high-dimensional datasets. However, many generation techniques do not give the data controller control over what…

Cryptography and Security · Computer Science 2022-11-22 Florimond Houssiau , Samuel N. Cohen , Lukasz Szpruch , Owen Daniel , Michaela G. Lawrence , Robin Mitra , Henry Wilde , Callum Mole

Synthetic health data have the potential to mitigate privacy concerns when sharing data to support biomedical research and the development of innovative healthcare applications. Modern approaches for data generation based on machine…

Machine Learning · Computer Science 2023-01-11 Chao Yan , Yao Yan , Zhiyu Wan , Ziqi Zhang , Larsson Omberg , Justin Guinney , Sean D. Mooney , Bradley A. Malin

Privacy poses a significant obstacle to the progress of learning analytics (LA), presenting challenges like inadequate anonymization and data misuse that current solutions struggle to address. Synthetic data emerges as a potential remedy,…

Cryptography and Security · Computer Science 2024-01-17 Qinyi Liu , Mohammad Khalil , Ronas Shakya , Jelena Jovanovic

Access to genomic data is highly regulated due to its sensitive nature. While safeguards are essential, cumbersome data access processes pose a significant barrier to the development of AI methods for genomics. Synthetic data generation can…

Cryptography and Security · Computer Science 2026-05-01 Daniil Filienko , Martine De Cock , Sikha Pentyala

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Synthetic data is emerging as a cost-effective solution necessary to meet the increasing data demands of AI development, created either from existing knowledge or derived from real data. The traditional classification of synthetic data…

Machine Learning · Computer Science 2025-08-07 Vibeke Binz Vallevik , Serena Elizabeth Marshall , Aleksandar Babic , Jan Franz Nygaard

This paper presents the results of a novel scoping review on the practical models for generating three different types of synthetic health records (SHRs): medical text, time series, and longitudinal data. The innovative aspects of the…

Machine Learning · Computer Science 2024-11-20 Mohammad Loni , Fatemeh Poursalim , Mehdi Asadi , Arash Gharehbaghi

Synthetic data has emerged as a powerful resource in life sciences, offering solutions for data scarcity, privacy protection and accessibility constraints. By creating artificial datasets that mirror the characteristics of real data, allows…

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