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Related papers: Explainable Artificial Intelligence for Drug Disco…

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Traditional drug discovery is a long, expensive, and complex process. Advances in Artificial Intelligence (AI) and Machine Learning (ML) are beginning to change this narrative. Here, we provide a comprehensive overview of different AI and…

Artificial Intelligence · Computer Science 2024-11-12 Khartik Uppalapati , Eeshan Dandamudi , S. Nick Ice , Gaurav Chandra , Kirsten Bischof , Christian L. Lorson , Kamal Singh

Language Models (LMs) have significantly advanced natural language processing and enabled remarkable progress across diverse domains, yet their black-box nature raises critical concerns about the interpretability of their internal…

Computation and Language · Computer Science 2025-09-29 Avash Palikhe , Zichong Wang , Zhipeng Yin , Rui Guo , Qiang Duan , Jie Yang , Wenbin Zhang

The adoption of intelligent systems creates opportunities as well as challenges for medical work. On the positive side, intelligent systems have the potential to compute complex data from patients and generate automated diagnosis…

Human-Computer Interaction · Computer Science 2019-02-19 Yao Xie , Ge Gao , Xiang 'Anthony' Chen

Large Language Models (LLMs) have played a pivotal role in advancing Artificial Intelligence (AI). However, despite their achievements, LLMs often struggle to explain their decision-making processes, making them a 'black box' and presenting…

Computation and Language · Computer Science 2025-06-30 Avash Palikhe , Zhenyu Yu , Zichong Wang , Wenbin Zhang

Explainable AI (XAI) is widely viewed as a sine qua non for ever-expanding AI research. A better understanding of the needs of XAI users, as well as human-centered evaluations of explainable models are both a necessity and a challenge. In…

Artificial Intelligence · Computer Science 2024-10-17 Yao Rong , Tobias Leemann , Thai-trang Nguyen , Lisa Fiedler , Peizhu Qian , Vaibhav Unhelkar , Tina Seidel , Gjergji Kasneci , Enkelejda Kasneci

With artificial intelligence (AI) embedded in many everyday software systems, effectively and reliably developing and maintaining AI systems becomes an essential skill for software developers. However, the complexity inherent to AI poses…

Human-Computer Interaction · Computer Science 2025-04-22 Thomas Weber

Introduction: Artificial intelligence (AI) is exhibiting tremendous potential to reduce the massive costs and long timescales of drug discovery. There are however important challenges currently limiting the impact and scope of AI models.…

Other Quantitative Biology · Quantitative Biology 2024-09-25 Ghita Ghislat , Saiveth Hernandez-Hernandez , Chayanit Piyawajanusorn , Pedro J. Ballester

In this survey, we address the key challenges in Large Language Models (LLM) research, focusing on the importance of interpretability. Driven by increasing interest from AI and business sectors, we highlight the need for transparency in…

Computation and Language · Computer Science 2024-07-23 Erik Cambria , Lorenzo Malandri , Fabio Mercorio , Navid Nobani , Andrea Seveso

Artificial Intelligence (AI) shows promising applications for the perception and planning tasks in autonomous driving (AD) due to its superior performance compared to conventional methods. However, inscrutable AI systems exacerbate the…

Robotics · Computer Science 2024-11-12 Anton Kuznietsov , Balint Gyevnar , Cheng Wang , Steven Peters , Stefano V. Albrecht

The remarkable achievements of Artificial Intelligence (AI) algorithms, particularly in Machine Learning (ML) and Deep Learning (DL), have fueled their extensive deployment across multiple sectors, including Software Engineering (SE).…

Software Engineering · Computer Science 2025-02-06 Sicong Cao , Xiaobing Sun , Ratnadira Widyasari , David Lo , Xiaoxue Wu , Lili Bo , Jiale Zhang , Bin Li , Wei Liu , Di Wu , Yixin Chen

Machine learning models are increasingly being used in critical sectors, but their black-box nature has raised concerns about accountability and trust. The field of explainable artificial intelligence (XAI) or explainable machine learning…

Artificial Intelligence · Computer Science 2023-11-14 Ryan Zhou , Ting Hu

Given the sheer volume of surgical procedures and the significant rate of postoperative fatalities, assessing and managing surgical complications has become a critical public health concern. Existing artificial intelligence (AI) tools for…

In recent years, Explainable AI (xAI) attracted a lot of attention as various countries turned explanations into a legal right. xAI allows for improving models beyond the accuracy metric by, e.g., debugging the learned pattern and…

Software Engineering · Computer Science 2022-10-05 Mohamed Karim Belaid , Eyke Hüllermeier , Maximilian Rabus , Ralf Krestel

Explainable Artificial Intelligence (XAI) is central to the debate on integrating Artificial Intelligence (AI) and Machine Learning (ML) algorithms into clinical practice. High-performing AI/ML models, such as ensemble learners and deep…

Machine Learning · Computer Science 2024-07-30 Alessandro De Carlo , Enea Parimbelli , Nicola Melillo , Giovanna Nicora

Most of state of the art methods applied on time series consist of deep learning methods that are too complex to be interpreted. This lack of interpretability is a major drawback, as several applications in the real world are critical…

Machine Learning · Computer Science 2021-04-05 Thomas Rojat , Raphaël Puget , David Filliat , Javier Del Ser , Rodolphe Gelin , Natalia Díaz-Rodríguez

The use of Deep Reinforcement Learning (DRL) schemes has increased dramatically since their first introduction in 2015. Though uses in many different applications are being found, they still have a problem with the lack of interpretability.…

Machine Learning · Computer Science 2023-03-09 Thomas Hickling , Abdelhafid Zenati , Nabil Aouf , Phillippa Spencer

Deep learning (DL) models have been popular due to their ability to learn directly from the raw data in an end-to-end paradigm, alleviating the concern of a separate error-prone feature extraction phase. Recent DL-based neuroimaging studies…

Machine Learning · Computer Science 2023-07-20 Md. Mahfuzur Rahman , Vince D. Calhoun , Sergey M. Plis

The increasing use of Machine Learning (ML) in sensitive domains such as healthcare, finance, and public policy has raised concerns about the transparency of automated decisions. Explainable AI (XAI) addresses this by clarifying how models…

Artificial Intelligence · Computer Science 2026-02-13 Natalia Abarca , Andrés Carvallo , Claudia López Moncada , Felipe Bravo-Marquez

As cannabis use has increased in recent years, researchers have come to rely on sophisticated machine learning models to predict cannabis use behavior and its impact on health. However, many artificial intelligence (AI) models lack…

Human-Computer Interaction · Computer Science 2025-03-11 Tongze Zhang , Tammy Chung , Anind Dey , Sang Won Bae

Discovering new medicines is the hallmark of human endeavor to live a better and longer life. Yet the pace of discovery has slowed down as we need to venture into more wildly unexplored biomedical space to find one that matches today's high…

Artificial Intelligence · Computer Science 2022-02-16 Tri Minh Nguyen , Thin Nguyen , Truyen Tran