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High-throughput phenotyping, the automated mapping of patient signs and symptoms to standardized ontology concepts, is essential to gaining value from electronic health records (EHR) in the support of precision medicine. Despite…

Artificial Intelligence · Computer Science 2024-06-24 Syed I. Munzir , Daniel B. Hier , Chelsea Oommen , Michael D. Carrithers

This paper introduces an approach that combines the language reasoning capabilities of large language models (LLMs) with the benefits of local training to tackle complex, domain-specific tasks. Specifically, the authors demonstrate their…

Computation and Language · Computer Science 2023-08-04 V. K. Cody Bumgardner , Aaron Mullen , Sam Armstrong , Caylin Hickey , Jeff Talbert

Despite the many use cases for large language models (LLMs) in creating personalized chatbots, there has been limited research on evaluating the extent to which the behaviors of personalized LLMs accurately and consistently reflect specific…

Computation and Language · Computer Science 2024-04-03 Hang Jiang , Xiajie Zhang , Xubo Cao , Cynthia Breazeal , Deb Roy , Jad Kabbara

Large Language Models (LLMs) consistently excel in diverse medical Natural Language Processing (NLP) tasks, yet their substantial computational requirements often limit deployment in real-world healthcare settings. In this work, we…

Computation and Language · Computer Science 2026-02-20 Pietro Ferrazzi , Mattia Franzin , Alberto Lavelli , Bernardo Magnini

It is well-established that more data generally improves AI model performance. However, data collection can be challenging for certain tasks due to the rarity of occurrences or high costs. These challenges are evident in our use case, where…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Martin Thißen , Thi Ngoc Diep Tran , Barbara Esteve Ratsch , Ben Joel Schönbein , Ute Trapp , Beate Egner , Romana Piat , Elke Hergenröther

Clinical notes recorded during a patient's perioperative journey holds immense informational value. Advances in large language models (LLMs) offer opportunities for bridging this gap. Using 84,875 pre-operative notes and its associated…

Computation and Language · Computer Science 2025-04-03 Charles Alba , Bing Xue , Joanna Abraham , Thomas Kannampallil , Chenyang Lu

Large-scale language models (LLMs) often offer clinical judgments based on incomplete information, increasing the risk of misdiagnosis. Existing studies have primarily evaluated confidence in single-turn, static settings, overlooking the…

Computation and Language · Computer Science 2026-01-23 Zhiyao Ren , Yibing Zhan , Siyuan Liang , Guozheng Ma , Baosheng Yu , Dacheng Tao

The recent emergence of Large Language Models (LLMs) has heralded a new era of human-AI interaction. These sophisticated models, exemplified by Chat-GPT and its successors, have exhibited remarkable capabilities in language understanding.…

Computation and Language · Computer Science 2024-07-26 Christopher Clarke , Yuzhao Heng , Lingjia Tang , Jason Mars

Digital health interventions increasingly deliver home exercise programs via sensor-equipped devices such as smartphones, enabling remote monitoring of adherence and performance. However, current software is usually authored before clinical…

Medical conversation summarization is integral in capturing information gathered during interactions between patients and physicians. Summarized conversations are used to facilitate patient hand-offs between physicians, and as part of…

Computation and Language · Computer Science 2021-11-30 Varun Nair , Namit Katariya , Xavier Amatriain , Ilya Valmianski , Anitha Kannan

Medical caption prediction which can be regarded as a task of medical report generation (MRG), requires the automatic generation of coherent and accurate captions for the given medical images. However, the scarcity of labelled medical…

Computer Vision and Pattern Recognition · Computer Science 2023-06-12 Bang Yang , Asif Raza , Yuexian Zou , Tong Zhang

In radiology, Artificial Intelligence (AI) has significantly advanced report generation, but automatic evaluation of these AI-produced reports remains challenging. Current metrics, such as Conventional Natural Language Generation (NLG) and…

Computation and Language · Computer Science 2024-02-20 Qingqing Zhu , Xiuying Chen , Qiao Jin , Benjamin Hou , Tejas Sudharshan Mathai , Pritam Mukherjee , Xin Gao , Ronald M Summers , Zhiyong Lu

Large language models (LLMs) have demonstrated remarkable capabilities for medical question answering and programming, but their potential for generating interpretable computable phenotypes (CPs) is under-explored. In this work, we…

Machine Learning · Computer Science 2025-08-08 Guilherme Seidyo Imai Aldeia , Daniel S. Herman , William G. La Cava

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinformatics data, demonstrated through two use cases: PRSGPT,…

Computation and Language · Computer Science 2026-01-21 Muhammad Muneeb , David B. Ascher

Self-assessment is a key aspect of reliable intelligence, yet evaluations of large language models (LLMs) focus mainly on task accuracy. We adapted the 10-item General Self-Efficacy Scale (GSES) to elicit simulated self-assessments from ten…

Artificial Intelligence · Computer Science 2025-11-27 Daniel I Jackson , Emma L Jensen , Syed-Amad Hussain , Emre Sezgin

Word-level psycholinguistic norms lend empirical support to theories of language processing. However, obtaining such human-based measures is not always feasible or straightforward. One promising approach is to augment human norming datasets…

With the rapid development of artificial intelligence (AI), large language models (LLMs) have shown strong capabilities in natural language understanding, reasoning, and generation, attracting amounts of research interest in applying LLMs…

Artificial Intelligence · Computer Science 2024-07-30 Tongyue Shi , Jun Ma , Zihan Yu , Haowei Xu , Minqi Xiong , Meirong Xiao , Yilin Li , Huiying Zhao , Guilan Kong

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

There is an increasing interest in developing artificial intelligence (AI) systems to process and interpret electronic health records (EHRs). Natural language processing (NLP) powered by pretrained language models is the key technology for…