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Histopathology remains the gold standard for cancer diagnosis and prognosis. With the advent of transcriptome profiling, multi-modal learning combining transcriptomics with histology offers more comprehensive information. However, existing…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Yupei Zhang , Xiaofei Wang , Anran Liu , Lequan Yu , Chao Li

Photomultiplier tubes (PMTs) are widely used as photon sensors for neutrino and dark matter detection. Accurate charge and time information extracted from PMT waveforms is crucial for event reconstruction. An algorithm based on…

Instrumentation and Detectors · Physics 2026-03-23 Xingyi Lin , Jinghuan Xu , Yongbo Huang , Jingzhe Tang , Tianying Xiao , Yingke Li

Ultrasound imaging is generally employed for real-time investigation of internal anatomy of the human body for disease identification. Delineation of the anatomical boundary of organs and pathological lesions is quite challenging due to the…

Computer Vision and Pattern Recognition · Computer Science 2019-01-23 Sumanth Nandamuri , Debarghya China , Pabitra Mitra , Debdoot Sheet

Dense retrieval calls for discriminative embeddings to represent the semantic relationship between query and document. It may benefit from the using of large language models (LLMs), given LLMs' strong capability on semantic understanding.…

Computation and Language · Computer Science 2025-11-25 Zheng Liu , Chaofan Li , Shitao Xiao , Yingxia Shao , Defu Lian

Multivariate linear mixed models (mvLMMs) have been widely used in many areas of genetics, and have attracted considerable recent interest in genome-wide association studies (GWASs). However, fitting mvLMMs is computationally non-trivial,…

Quantitative Methods · Quantitative Biology 2013-09-13 Xiang Zhou , Matthew Stephens

Decoding sits between a language model and everything we do with it, yet it is still treated as a heuristic knob-tuning exercise. We argue decoding should be understood as a principled optimisation layer: at each token, we solve a…

Machine Learning · Computer Science 2026-02-26 Xiaotong Ji , Rasul Tutunov , Matthieu Zimmer , Haitham Bou-Ammar

This paper focuses on solving a challenging problem of blind deconvolution demixing involving modulated inputs. Specifically, multiple input signals $s_n(t)$, each bandlimited to $B$ Hz, are modulated with known random sequences $r_n(t)$…

Signal Processing · Electrical Eng. & Systems 2026-02-17 Humera Hameed , Ali Ahmed

The analysis of multivariate time series data is challenging due to the various frequencies of signal changes that can occur over both short and long terms. Furthermore, standard deep learning models are often unsuitable for such datasets,…

Machine Learning · Computer Science 2023-06-21 Iman Deznabi , Madalina Fiterau

Covariate adjustment is an approach to improve the precision of trial analyses by adjusting for baseline variables that are prognostic of the primary endpoint. Motivated by the SEARCH Universal HIV Test-and-Treat Trial (2013-2017), we tell…

Methodology · Statistics 2025-12-16 Laura B. Balzer , Mark J. van der Laan , Maya L. Petersen

Ultrasound imaging is widely used for real-time, noninvasive diagnosis, but speckle and related artifacts reduce image quality and can hinder interpretation. We present a diffusion-based ultrasound despeckling method built on the Image…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Shuoqi Chen , Yujia Wu , Geoffrey P. Luke

We introduce a new convolutional AutoEncoder architecture for user modelling and recommendation tasks with several improvements over the state of the art. Firstly, our model has the flexibility to learn a set of associations and…

Machine Learning · Computer Science 2025-09-10 Antoine Ledent , Petr Kasalický , Rodrigo Alves , Hady W. Lauw

The function of biomolecules such as proteins depends on their ability to interconvert between a wide range of structures or "conformations." Researchers have endeavored for decades to develop computational methods to predict the…

Biomolecules · Quantitative Biology 2026-02-05 Daniel D. Richman , Jessica Karaguesian , Carl-Mikael Suomivuori , Ron O. Dror

Large-scale biobanks are being collected around the world in efforts to better understand human health and risk factors for disease. They often survey hundreds of thousands of individuals, combining questionnaires with clinical, genetic,…

Quantitative Methods · Quantitative Biology 2019-03-19 Qifan Yang , Gennady V. Roshchupkin , Wiro J. Niessen , Sarah E. Medland , Alyssa H. Zhu , Paul M. Thompson , Neda Jahanshad

This article focuses on covariance estimation for multi-study data. Popular approaches employ factor-analytic terms with shared and study-specific loadings that decompose the variance into (i) a shared low-rank component, (ii)…

Methodology · Statistics 2026-01-26 Lorenzo Mauri , Niccolò Anceschi , David B. Dunson

While meta-analyzing retrospective cancer patient cohorts, an investigation of differences in the expressions of target oncogenes across cancer subtypes is of substantial interest because the results may uncover novel tumorigenesis…

Methodology · Statistics 2023-07-03 Subharup Guha , David C. Christiani , S. V. Subramanian , Yi Li

Decompilation is the procedure of transforming binary programs into a high-level representation, such as source code, for human analysts to examine. While modern decompilers can reconstruct and recover much information that is discarded…

Machine Learning · Computer Science 2021-03-25 Pratyay Banerjee , Kuntal Kumar Pal , Fish Wang , Chitta Baral

The enzyme turnover rate is a fundamental parameter in enzyme kinetics, reflecting the catalytic efficiency of enzymes. However, enzyme turnover rates remain scarce across most organisms due to the high cost and complexity of experimental…

Machine Learning · Computer Science 2025-09-16 Bozhen Hu , Cheng Tan , Siyuan Li , Jiangbin Zheng , Sizhe Qiu , Jun Xia , Stan Z. Li

Turbulence-degraded image frames are distorted by both turbulent deformations and space-time-varying blurs. To suppress these effects, we propose a multi-frame reconstruction scheme to recover a latent image from the observed image…

Computer Vision and Pattern Recognition · Computer Science 2017-12-12 Chun Pong Lau , Yu Hin Lai , Lok Ming Lui

Recent studies utilize multiple kernel learning to deal with incomplete-data problem. In this study, we introduce new methods that do not only complete multiple incomplete kernel matrices simultaneously, but also allow control of the…

Machine Learning · Computer Science 2018-12-26 Rachelle Rivero , Tsuyoshi Kato

Chest radiographs are used for the diagnosis of multiple critical illnesses (e.g., Pneumonia, heart failure, lung cancer), for this reason, systems for the automatic or semi-automatic analysis of these data are of particular interest. An…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Declan McIntosh , Tunai Porto Marques , Alexandra Branzan Albu
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