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Thanks to automated cryo-EM and GPU-accelerated processing, single-particle cryo-EM has become a rapid structure determination method that permits capture of dynamical structures of molecules in solution, which has been recently…

Quantitative Methods · Quantitative Biology 2025-09-30 Szu-Chi Chung , Cheng-Yu Hung , Huei-Lun Siao , Hung-Yi Wu , Wei-Hau Chang , I-Ping Tu

Feature matching is an important technique to identify a single object in different images. It helps machines to construct recognition of a specific object from multiple perspectives. For years, feature matching has been commonly used in…

Computer Vision and Pattern Recognition · Computer Science 2020-10-26 Hang Zhu , Zihao Wang

Instance-level alignment is widely exploited for person re-identification, e.g. spatial alignment, latent semantic alignment and triplet alignment. This paper probes another feature alignment modality, namely cluster-level feature alignment…

Computer Vision and Pattern Recognition · Computer Science 2020-08-18 Qiuyu Chen , Wei Zhang , Jianping Fan

The central problem in cryo-electron microscopy (cryo-EM) is to recover the 3D structure from noisy 2D projection images which requires estimating the missing projection angles (poses). Recent methods attempted to solve the 3D…

Computer Vision and Pattern Recognition · Computer Science 2023-02-15 Lin Yao , Ruihan Xu , Zhifeng Gao , Guolin Ke , Yuhang Wang

Achieving a comprehensive understanding of the behaviour of proteins is greatly facilitated by the knowledge of their structures, thermodynamics and dynamics. All this information can be provided in an effective manner in terms of…

Quantitative Methods · Quantitative Biology 2019-03-27 Massimiliano Bonomi , Michele Vendruscolo

Cryo-electron microscopy (cryo-EM) enables the atomic-resolution visualization of biomolecules; however, modern direct detectors generate data volumes that far exceed the available storage and transfer bandwidth, thereby constraining…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Zain Shabeeb , Daniel Saeedi , Darin Tsui , Vida Jamali , Amirali Aghazadeh

Constructing atomic models from cryo-electron microscopy (cryo-EM) maps is a crucial yet intricate task in structural biology. While advancements in deep learning, such as convolutional neural networks (CNNs) and graph neural networks…

Quantitative Methods · Quantitative Biology 2024-11-01 Xin , Ma , Dong Si

We revisit the topic of common lines between projection images in single particle cryo-electron microscopy (cryo-EM). We derive a novel low-rank constraint on a certain $2n \times n$ matrix storing properly-scaled basis vectors for the…

Optimization and Control · Mathematics 2024-06-10 Tommi Muller , Adriana L. Duncan , Eric J. Verbeke , Joe Kileel

Recent breakthroughs in high-resolution imaging of biomolecules in solution with cryo-electron microscopy (cryo-EM) have unlocked new doors for the reconstruction of molecular volumes, thereby promising further advances in biology,…

Image and Video Processing · Electrical Eng. & Systems 2022-05-27 Claire Donnat , Axel Levy , Frederic Poitevin , Ellen Zhong , Nina Miolane

Cryo-electron microscopy is a state-of-the-art method for determining high-resolution three-dimensional models of molecules, from their two-dimensional projection images taken by an electron microscope. A crucial step in this method is to…

Image and Video Processing · Electrical Eng. & Systems 2022-12-16 Eitan Rosen , Yoel Shkolnisky

One of the main challenges in simultaneous localization and mapping (SLAM) is real-time processing. High-computational loads linked to data acquisition and processing complicate this task. This article presents an efficient feature…

We introduce a new rotationally invariant viewing angle classification method for identifying, among a large number of Cryo-EM projection images, similar views without prior knowledge of the molecule. Our rotationally invariant features are…

Biomolecules · Quantitative Biology 2014-03-19 Zhizhen Zhao , Amit Singer

Multimodal representation learning aims to capture both shared and complementary semantic information across multiple modalities. However, the intrinsic heterogeneity of diverse modalities presents substantial challenges to achieve…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Chengxuan Qian , Shuo Xing , Shawn Li , Yue Zhao , Zhengzhong Tu

The Coherence Length Diagram and the related maps have been shown to represent a useful tool for image analysis. Setting threshold parameters is one of the most important issues when dealing with such applications, as they affect both the…

Computer Vision and Pattern Recognition · Computer Science 2014-09-12 Roberto Marazzato , Amelia Carolina Sparavigna

Cryo-EM data processing typically focuses on the structure of the main conformational state under investigation and discards images that belong to other states. This approach can reach atomic resolution, but ignores vast amounts of valuable…

Biomolecules · Quantitative Biology 2024-02-20 Felix Lambrecht , Andreas Kröpelin , Mario Lüttich , Michael Habeck , David Haselbach , Holger Stark

In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer

Existing 3D foundation models typically align point clouds to frozen vision-language spaces like CLIP, which achieve strong cross-modal retrieval by compressing 3D shape into a global vector. However, this global-only alignment cannot…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Zebin He , Mingxin Yang , Shuhui Yang , Hanxiao Sun , Xintong Han , Chunchao Guo , Wenhan Luo

Carotid atherosclerosis is a focal disease at the bifurcations of the carotid artery. To quantitatively monitor the local changes in the vessel-wall-plus-plaque thickness (VWT) and compare the VWT distributions for different patients or for…

Computational Geometry · Computer Science 2020-10-30 Gary P. T. Choi , Bernard Chiu , Chris H. Rycroft

In this paper, we present an efficient visual SLAM system designed to tackle both short-term and long-term illumination challenges. Our system adopts a hybrid approach that combines deep learning techniques for feature detection and…

Robotics · Computer Science 2025-02-28 Kuan Xu , Yuefan Hao , Shenghai Yuan , Chen Wang , Lihua Xie

We present a novel approach for relocalization or place recognition, a fundamental problem to be solved in many robotics, automation, and AR applications. Rather than relying on often unstable appearance information, we consider a situation…

Robotics · Computer Science 2022-08-30 Lan Hu , Zhongwei Luo , Runze Yuan , Yuchen Cao , Jiaxin Wei , Kai Wangand Laurent Kneip