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Related papers: Intermittent Control for Safe Long-Acting Insulin …

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In this paper, we present a model free approach to calculate long-acting insulin doses for Type 2 Diabetic (T2D) subjects in order to bring their blood glucose (BG) concentration to be within a safe range. The proposed strategy tunes the…

Systems and Control · Electrical Eng. & Systems 2022-12-29 Mohamad Al Ahdab , Torben Knudsen , Jakob Stoustrup , John Leth

In type 2 diabetes (T2D) treatment, finding a safe and effective basal insulin dose is a challenge. The dose-response is highly individual and to ensure safety, people with T2D titrate by slowly increasing the daily insulin dose to meet…

Systems and Control · Electrical Eng. & Systems 2022-11-28 Sarah Ellinor Engell , Tinna Björk Aradóttir , Tobias K. S. Ritschel , Henrik Bengtsson , John Bagterp Jørgensen

Despite recent advances in insulin preparations and technology, adjusting insulin remains an ongoing challenge for the majority of people with type 1 diabetes (T1D) and longstanding type 2 diabetes (T2D). In this study, we propose the…

People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring…

Signal Processing · Electrical Eng. & Systems 2020-09-08 Taiyu Zhu , Kezhi Li , Pau Herrero , Pantelis Georgiou

People with type 1 diabetes (T1D) lack the ability to produce the insulin their bodies need. As a result, they must continually make decisions about how much insulin to self-administer to adequately control their blood glucose levels.…

Machine Learning · Computer Science 2020-09-22 Ian Fox , Joyce Lee , Rodica Pop-Busui , Jenna Wiens

Patients with Type I Diabetes (T1D) must take insulin injections to prevent the serious long term effects of hyperglycemia - high blood glucose (BG). Patients must also be careful not to inject too much insulin because this could induce…

Machine Learning · Computer Science 2019-04-01 Neil C. Borle , Edmond A. Ryan , Russell Greiner

People with type 1 diabetes (T1D) struggle to calculate the optimal insulin dose at mealtime, especially when under multiple daily injections (MDI) therapy. Effectively, they will not always perform rigorous and precise calculations, but…

Artificial Intelligence · Computer Science 2023-09-19 Anas El Fathi , Marc D. Breton

While the Artificial Pancreas is effective in regulating the blood glucose in the safe range of 70-180 mg/dl in type 1 diabetic patients, the high intra-patient variability, as well as exogenous meal disturbances, poses a serious challenge.…

Systems and Control · Electrical Eng. & Systems 2022-06-30 Bhabani Shankar Dey , Anirudh Nath , Abhilash Patel , Indra Narayan Kar

The goal of this paper is to propose a new mathematical model for the combined effect of different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) patients. The model gives the possibility to take into…

Systems and Control · Electrical Eng. & Systems 2023-01-11 Mohamad Al Ahdab , John Leth , Torben Knudsen , Peter Vestergaard , Henrik Clausen

Diabetes cases worldwide have risen steadily over the past decades, lending urgency to the search for more efficient, effective, and personalized ways to treat the disease. Current treatment strategies, however, may fail to maintain…

Tissues and Organs · Quantitative Biology 2014-03-05 S. M. Kissler , C. Cichowitz , S. Sankaranarayanan , D. M. Bortz

Intensive care unit (ICU) patients exhibit erratic blood glucose (BG) fluctuations, including hypoglycemic and hyperglycemic episodes, and require exogenous insulin delivery to keep their BG in healthy ranges. Glycemic control via glycemic…

Background: Accurate week-ahead forecasts of continuous glucose monitoring (CGM) derived metrics could enable proactive diabetes management, but relative performance of modern tabular learning approaches is incompletely defined. Methods: We…

Other Quantitative Biology · Quantitative Biology 2026-01-05 Simon Lebech Cichosz , Stine Hangaard , Thomas Kronborg , Peter Vestergaard , Morten Hasselstrøm Jensen

Diabetes mellitus is a global health crisis characterized by poor blood sugar regulation, impacting millions of people worldwide and leading to severe complications and mortality. Although Type 1 Diabetes Mellitus (T1DM) has a lower number…

Other Quantitative Biology · Quantitative Biology 2025-04-14 Rinrada Jadsadaphongphaibool , Dadi Bi , Christian D. Lorenz , Yansha Deng , Robert Schober

Modern treatments for Type 1 diabetes (T1D) use devices known as artificial pancreata (APs), which combine an insulin pump with a continuous glucose monitor (CGM) operating in a closed-loop manner to control blood glucose levels. In…

Machine Learning · Computer Science 2018-12-04 Matthew O'Kelly , Aman Sinha , Justin Norden , Hongseok Namkoong

Type 1 Diabetes (T1D) management requires continuous adjustment of insulin and lifestyle behaviors to maintain blood glucose within a safe target range. Although automated insulin delivery (AID) systems have improved glycemic outcomes, many…

Self-monitoring of blood glucose (SMBG) and continuous glucose monitoring (CGM) are commonly used by type 1 diabetes (T1D) patients to measure glucose concentrations. The proposed adaptive basal-bolus algorithm (ABBA) supports inputs from…

Systems and Control · Electrical Eng. & Systems 2024-12-20 Qingnan Sun , Marko V. Jankovic , João Budzinski , Brett Moore , Peter Diem , Christoph Stettler , Stavroula G. Mougiakakou

Background and objective: Hybrid automated insulin delivery (hAID) systems represent the most advanced therapy for type 1 diabetes (T1D). Current systems rely on linear or linearized models of glucose homeostasis, which may compromise…

Systems and Control · Electrical Eng. & Systems 2025-12-08 Vihangkumar V. Naik , Eleonora Manzoni , Clara Escorihuela-Altaba , Jose Garcia-Tirado

Calculating mealtime insulin doses poses a significant challenge for individuals with Type 1 Diabetes (T1D). Doses should perfectly compensate for expected post-meal glucose excursions, requiring a profound understanding of the individual's…

Quantitative Methods · Quantitative Biology 2024-06-24 Anas El Fathi , Elliott Pryor , Marc D. Breton

We propose and create an incentive based recommendation algorithm aimed at improving the lifestyle of diabetic patients. This algorithm is integrated into a real world mobile application to provide personalized health recommendations.…

Human-Computer Interaction · Computer Science 2025-04-22 Wasim Abbas , Hafiz Syed Muhammad Bilal , Asim Abbas , Muhammad Afzal , Je-Hoon Lee

The conventional method of glucose measurement such as pricking blood from the body is prevalent which brings pain and trauma. Invasive methods of measurement sometimes raise the risk of blood infection to the patient. Sometimes, some of…

Medical Physics · Physics 2023-08-24 Prateek Jain , Amit Joshi , Saraju Mohanty
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