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The early detection of Alzheimer's disease (AD) requires an understanding of the relationships between a wide range of features. Conditional independencies and partial correlations are suitable measures for these relationships, because they…

Applications · Statistics 2025-01-22 Lucas Vogels , Reza Mohammadi , Marit Schoonhoven , S. Ilker Birbil , Martin Dyrba

In biomedical image analysis, the applicability of deep learning methods is directly impacted by the quantity of image data available. This is due to deep learning models requiring large image datasets to provide high-level performance.…

Machine Learning · Computer Science 2023-08-14 Muhammad Muneeb Saad , Ruairi O'Reilly , Mubashir Husain Rehmani

Whereas MRI produces anatomic information about the brain, functional MRI (fMRI) tells us about neural activity within the brain, including how various regions communicate with each other. The full chorus of conversations within the brain…

Neural and Evolutionary Computing · Computer Science 2022-11-29 Joseph Stember , Mehrnaz Jenabi , Luca Pasquini , Kyung Peck , Andrei Holodny , Hrithwik Shalu

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Yang Ming , Jiang Shi Zhong , Zhou Su Juan

Alzheimer's disease is a progressive form of dementia that results in problems with memory, thinking, and behavior. It often starts with abnormal aggregation and deposition of beta amyloid and tau, followed by neuronal damage such as…

Applications · Statistics 2022-06-03 Dengdeng Yu , Linbo Wang , Dehan Kong , Hongtu Zhu

Integrating brain imaging data with clinical reports offers a valuable opportunity to leverage complementary multimodal information for more effective and timely diagnosis in practical clinical settings. This approach has gained significant…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Jing Zhang , Xiaowei Yu , Minheng Chen , Lu Zhang , Tong Chen , Yan Zhuang , Chao Cao , Yanjun Lyu , Li Su , Tianming Liu , Dajiang Zhu

Recent advances in neuroimaging have deepened our understanding of the brain's complex functional and structural organization. Among these, functional Magnetic Resonance Imaging (fMRI) - particularly resting-state fMRI (rs-fMRI) - has…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 M. Moein Esfahani , Sepehr Salem Ghahfarokhi , Mohammed Alser , Jingyu Liu , Vince Calhoun

To understand multifactorial conditions such as Alzheimers disease (AD) we need brain signatures that predict the impact of multiple pathologies and their interactions. To help uncover the relationships between brain circuits and cognitive…

Quantitative Methods · Quantitative Biology 2018-12-31 Alexandra Badea , Natalie A Delpratt , RJ Anderson , Russell Dibb , Yi Qi , Hongjiang Wei , Chunlei Liu , William C Wetsel , Brian B Avants , Carol Colton

It is of great significance to apply deep learning for the early diagnosis of Alzheimer's Disease (AD). In this work, a novel tensorizing GAN with high-order pooling is proposed to assess Mild Cognitive Impairment (MCI) and AD. By…

Machine Learning · Computer Science 2020-08-04 Wen Yu , Baiying Lei , Michael K. Ng , Albert C. Cheung , Yanyan Shen , Shuqiang Wang

Brain network analysis plays an increasingly important role in studying brain function and the exploring of disease mechanisms. However, existing brain network construction tools have some limitations, including dependency on empirical…

Neurons and Cognition · Quantitative Biology 2024-07-29 Yongcheng Zong , Shuqiang Wang

Quantifying functional connectivity (FC), a vital metric for the diagnosis of various brain disorders, traditionally relies on the use of a pre-defined brain atlas. However, using such atlases can lead to issues regarding selection bias and…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Tyler Ward , Abdullah-Al-Zubaer Imran

Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to…

Recently, machine learning techniques especially predictive modeling and pattern recognition in biomedical sciences from drug delivery system to medical imaging has become one of the important methods which are assisting researchers to have…

Computer Vision and Pattern Recognition · Computer Science 2017-05-23 Saman Sarraf , Ghassem Tofighi

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

Machine Learning · Computer Science 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

In medical imaging, image synthesis is the estimation process of one image (sequence, modality) from another image (sequence, modality). Since images with different modalities provide diverse biomarkers and capture various features,…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Firoozeh Shomal Zadeh , Sevda Molani , Maysam Orouskhani , Marziyeh Rezaei , Mehrzad Shafiei , Hossein Abbasi

Fusing medical images and the corresponding 3D shape representation can provide complementary information and microstructure details to improve the operational performance and accuracy in brain surgery. However, compared to the substantial…

Image and Video Processing · Electrical Eng. & Systems 2021-07-22 Bowen Hu , Baiying Lei , Yanyan Shen , Yong Liu , Shuqiang Wang

Recent progress in Generative Adversarial Networks (GANs) has shown promising signs of improving GAN training via architectural change. Despite some early success, at present the design of GAN architectures requires human expertise,…

Machine Learning · Computer Science 2019-06-27 Hanchao Wang , Jun Huan

Insomnia affects a vast population of the world and can have a wide range of causes. Existing treatments for insomnia have been linked with many side effects like headaches, dizziness, etc. As such, there is a clear need for improved…

Signal Processing · Electrical Eng. & Systems 2025-07-22 Kevin Monteiro , Sam Nallaperuma-Herzberg , Martina Mason , Steve Niederer

Generative adversarial network (GAN) still exists some problems in dealing with speech enhancement (SE) task. Some GAN-based systems adopt the same structure from Pixel-to-Pixel directly without special optimization. The importance of the…

Audio and Speech Processing · Electrical Eng. & Systems 2021-03-09 Huixiang Huang , Renjie Wu , Jingbiao Huang , Jucai Lin , Jun Yin

We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused…

Machine Learning · Computer Science 2020-04-01 Sebastian Pölsterl , Ignacio Sarasua , Benjamín Gutiérrez-Becker , Christian Wachinger