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Organoids are complex, three dimensional, self-organizing cell cultures which manifest organ-like features and represent a powerful platform for studying human disease and developing treatment options. Organoid development is characterized…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Chase Cartwright , Gongbo Guo , Sai Teja Pusuluri , Christopher N. Mayhew , Mark Hester , Horacio E. Castillo

High-throughput image analysis in the biomedical domain has gained significant attention in recent years, driving advancements in drug discovery, disease prediction, and personalized medicine. Organoids, specifically, are an active area of…

Recent advances in brain organoid technology are exciting new ways, which have the potential to change the way how doctors and researchers understand and treat cerebral diseases. Despite the remarkable use of brain organoids derived from…

Image and Video Processing · Electrical Eng. & Systems 2022-11-03 Jingli Shi

The objective of this paper is to significantly reduce the manual workload required from medical professionals in complex 3D segmentation tasks that cannot be yet fully automated. For instance, in radiotherapy planning, organs at risk must…

Volume electron microscopy is the method of choice for the in-situ interrogation of cellular ultrastructure at the nanometer scale. Recent technical advances have led to a rapid increase in large raw image datasets that require…

Computer Vision and Pattern Recognition · Computer Science 2023-03-08 Andreas Müller , Deborah Schmidt , Lucas Rieckert , Michele Solimena , Martin Weigert

Stem cell-derived organoids are a promising tool to model native human tissues as they resemble human organs functionally and structurally compared to traditional monolayer cell-based assays. For instance, colon organoids can spontaneously…

Quantitative Methods · Quantitative Biology 2022-10-14 Lyan Abdul , Jocelyn Xu , Alexander Sotra , Abbas Chaudary , Jerry Gao , Shravanthi Rajasekar , Nicky Anvari , Hamidreza Mahyar , Boyang Zhang

Organ segmentation is a fundamental task in medical imaging since it is useful for many clinical automation pipelines. However, some tasks do not require full segmentation. Instead, a classifier can identify the selected organ without…

Computer Vision and Pattern Recognition · Computer Science 2025-01-13 Halid Ziya Yerebakan , Yoshihisa Shinagawa , Gerardo Hermosillo Valadez

Modeling the 3D structures of cells and tissues is crucial in biology. Sequential cross-sectional images from electron microscopy provide high-resolution intracellular structure information. The segmentation of complex cell structures…

Quantitative Methods · Quantitative Biology 2025-02-14 Jin Kousaka , Atsuko H. Iwane , Yuichi Togashi

We propose a novel point cloud based 3D organ segmentation pipeline utilizing deep Q-learning. In order to preserve shape properties, the learning process is guided using a statistical shape model. The trained agent directly predicts…

Computer Vision and Pattern Recognition · Computer Science 2018-06-18 Xia Zhong , Mario Amrehn , Nishant Ravikumar , Shuqing Chen , Norbert Strobel , Annette Birkhold , Markus Kowarschik , Rebecca Fahrig , Andreas Maier

Various structures in human physiology follow a treelike morphology, which often expresses complexity at very fine scales. Examples of such structures are intrathoracic airways, retinal blood vessels, and hepatic blood vessels. Large…

Image and Video Processing · Electrical Eng. & Systems 2022-09-23 Hao Li , Zeyu Tang , Yang Nan , Guang Yang

Aortic shape analysis plays a key role in cardiovascular diagnostics, treatment planning, and understanding disease progression. We present a robust, fully automated pipeline for aortic shape analysis from cardiac MRI, combining deep…

Tissues and Organs · Quantitative Biology 2025-09-15 Nairouz Shehata , Amr Elsawy , Mohamed Nagy , Muhammad ElMahdy , Mariam Ali , Soha Romeih , Heba Aguib , Magdi Yacoub , Ben Glocker

Semantic segmentation is an import task in the medical field to identify the exact extent and orientation of significant structures like organs and pathology. Deep neural networks can perform this task well by leveraging the information…

Computer Vision and Pattern Recognition · Computer Science 2019-09-18 Abhijeet Parida , Arianne Tran , Nassir Navab , Shadi Albarqouni

We present a novel approach for benchmarking and validating quantitative phase tomography (QPT) systems using three-dimensional microphantoms. These microphantoms, crafted from biological and imaging data, replicate the optical and…

Automated patient positioning can improve radiology workflow efficiency by reducing the time required for manual table adjustments and scout-based scan planning. We propose a learning-based framework that predicts 3D organ locations and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Eytan Kats , Kai Geissler , Daniel Mensing , Julien Senegas , Jochen G. Hirsch , Stefan Heldman , Mattias P. Heinrich

Image segmentation remains a pivotal component in medical image analysis, aiding in the extraction of critical information for precise diagnostic practices. With the advent of deep learning, automated image segmentation methods have risen…

Image and Video Processing · Electrical Eng. & Systems 2024-03-07 Nhat-Tan Bui , Dinh-Hieu Hoang , Minh-Triet Tran , Gianfranco Doretto , Donald Adjeroh , Brijesh Patel , Arabinda Choudhary , Ngan Le

Grape cluster architecture and compactness are complex traits influencing disease susceptibility, fruit quality, and yield. Evaluation methods for these traits include visual scoring, manual methodologies, and computer vision, with the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Efrain Torres-Lomas , Jimena Lado-Jimena , Guillermo Garcia-Zamora , Luis Diaz-Garcia

Tracking cells and detecting mitotic events in time-lapse microscopy image sequences is a crucial task in biomedical research. However, it remains highly challenging due to dividing objects, low signal-tonoise ratios, indistinct boundaries,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-15 Zhu Chen , Mert Edgü , Er Jin , Johannes Stegmaier

The analysis of dynamic organelles remains a formidable challenge, though key to understanding biological processes. We introduce Nellie, an automated and unbiased user-friendly pipeline for segmentation, tracking, and feature extraction of…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Austin E. Y. T. Lefebvre , Gabriel Sturm , Ting-Yu Lin , Emily Stoops , Magdalena Preciado Lopez , Benjamin Kaufmann-Malaga , Kayley Hake

In biological and medical research, scientists now routinely acquire microscopy images of hundreds of morphologically heterogeneous organoids and are then faced with the task of finding patterns in the image collection, i.e., subsets of…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Jannik Presberger , Rashmiparvathi Keshara , David Stein , Yung Hae Kim , Anne Grapin-Botton , Bjoern Andres

Segmentation of multiple organs-at-risk (OARs) is essential for radiation therapy treatment planning and other clinical applications. We developed an Automated deep Learning-based Abdominal Multi-Organ segmentation (ALAMO) framework based…

Image and Video Processing · Electrical Eng. & Systems 2020-08-25 Yuhua Chen , Dan Ruan , Jiayu Xiao , Lixia Wang , Bin Sun , Rola Saouaf , Wensha Yang , Debiao Li , Zhaoyang Fan
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