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Convolutional neural networks can be trained to perform histology slide classification using weak annotations with multiple instance learning (MIL). However, given the paucity of labeled histology data, direct application of MIL can easily…

Computer Vision and Pattern Recognition · Computer Science 2019-11-05 Ming Y. Lu , Richard J. Chen , Jingwen Wang , Debora Dillon , Faisal Mahmood

Whole-slide image (WSI) classification in computational pathology is commonly formulated as slide-level Multiple Instance Learning (MIL) with a single global bag representation. However, slide-level MIL is fundamentally underconstrained:…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Syed Fahim Ahmed , Gnanesh Rasineni , Florian Koehler , Abu Zahid Bin Aziz , Mei Wang , Attila Gyulassy , Brian Summa , J. Quincy Brown , Valerio Pascucci , Shireen Y. Elhabian

Training deep object detectors demands expensive bounding box annotation. Active learning (AL) is a promising technique to alleviate the annotation burden. Performing AL at box-level for object detection, i.e., selecting the most…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Jingyi Liao , Xun Xu , Chuan-Sheng Foo , Lile Cai

Obtaining labels for medical (image) data requires scarce and expensive experts. Moreover, due to ambiguous symptoms, single images rarely suffice to correctly diagnose a medical condition. Instead, it often requires to take additional…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Diana Davletshina , Valentyn Melnychuk , Viet Tran , Hitansh Singla , Max Berrendorf , Evgeniy Faerman , Michael Fromm , Matthias Schubert

Leveraging multimodal data, particularly the integration of whole-slide histology images (WSIs) and transcriptomic profiles, holds great promise for improving cancer survival prediction. However, excessive redundancy in multimodal data can…

Image and Video Processing · Electrical Eng. & Systems 2025-03-07 Hong Liu , Haosen Yang , Federica Eduati , Josien P. W. Pluim , Mitko Veta

Radiologists are in short supply globally, and deep learning models offer a promising solution to address this shortage as part of clinical decision-support systems. However, training such models often requires expensive and time-consuming…

Computation and Language · Computer Science 2023-07-10 Alessandro Wollek , Philip Haitzer , Thomas Sedlmeyr , Sardi Hyska , Johannes Rueckel , Bastian Sabel , Michael Ingrisch , Tobias Lasser

Background: Radiography (X-rays) is the dominant modality in orthopedics, and improving the interpretation of radiographs is clinically relevant. Machine learning (ML) has revolutionized data analysis and has been applied to medicine, with…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Jakub Olczak , Max Gordon

Accurate diagnosis of breast cancer in histopathology images is challenging due to the heterogeneity of cancer cell growth as well as of a variety of benign breast tissue proliferative lesions. In this paper, we propose a practical and…

Computer Vision and Pattern Recognition · Computer Science 2020-05-06 Xingyu Li , Marko Radulovic , Ksenija Kanjer , Konstantinos N. Plataniotis

Multiple Instance Learning is the predominant method for Whole Slide Image classification in digital pathology, enabling the use of slide-level labels to supervise model training. Although MIL eliminates the tedious fine-grained annotation…

Computer Vision and Pattern Recognition · Computer Science 2025-05-28 Chen Shu , Boyu Fu , Yiman Li , Ting Yin , Wenchuan Zhang , Jie Chen , Yuhao Yi , Hong Bu

Artificial Intelligence (AI) has great potential to improve health outcomes by training systems on vast digitized clinical datasets. Computational Pathology, with its massive amounts of microscopy image data and impact on diagnostics and…

Image and Video Processing · Electrical Eng. & Systems 2024-05-24 Gabriele Campanella , Eugene Fluder , Jennifer Zeng , Chad Vanderbilt , Thomas J. Fuchs

The implementation of Autonomous Driving (AD) technologies within urban environments presents significant challenges. These challenges necessitate the development of advanced perception systems and motion planning algorithms capable of…

Robotics · Computer Science 2024-02-26 Yanliang Huang , Liguo Zhou , Chang Liu , Alois Knoll

Thoracic disease detection from chest radiographs using deep learning methods has been an active area of research in the last decade. Most previous methods attempt to focus on the diseased organs of the image by identifying spatial regions…

Image and Video Processing · Electrical Eng. & Systems 2022-10-07 Uday Kamal , Mohammad Zunaed , Nusrat Binta Nizam , Taufiq Hasan

Anomaly detection (AD) is the identification of data samples that do not fit a learned data distribution. As such, AD systems can help physicians to determine the presence, severity, and extension of a pathology. Deep generative models,…

Image and Video Processing · Electrical Eng. & Systems 2021-04-12 Jaime Simarro , Ezequiel de la Rosa , Thijs Vande Vyvere , David Robben , Diana M. Sima

Automated diagnosis of Alzheimer Disease(AD) from brain imaging, such as magnetic resonance imaging (MRI), has become increasingly important and has attracted the community to contribute many deep learning methods. However, many of these…

Image and Video Processing · Electrical Eng. & Systems 2024-03-01 Yifeng Wang , Ke Chen , Haohan Wang

Accurate identification and localization of abnormalities from radiology images play an integral part in clinical diagnosis and treatment planning. Building a highly accurate prediction model for these tasks usually requires a large number…

Computer Vision and Pattern Recognition · Computer Science 2018-06-22 Zhe Li , Chong Wang , Mei Han , Yuan Xue , Wei Wei , Li-Jia Li , Li Fei-Fei

3D medical image segmentation is a challenging task with crucial implications for disease diagnosis and treatment planning. Recent advances in deep learning have significantly enhanced fully supervised medical image segmentation. However,…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Runmin Jiang , Zhaoxin Fan , Junhao Wu , Lenghan Zhu , Xin Huang , Tianyang Wang , Heng Huang , Min Xu

Precise anomaly detection in medical images is critical for clinical decision-making. While recent unsupervised or semi-supervised anomaly detection methods trained on large-scale normal data show promising results, they lack fine-grained…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Yue Zhou , Yuan Bi , Wenjuan Tong , Wei Wang , Nassir Navab , Zhongliang Jiang

Anomaly detection in computational pathology aims to identify rare and scarce anomalies where disease-related data are often limited or missing. Existing anomaly detection methods, primarily designed for industrial settings, face…

Computer Vision and Pattern Recognition · Computer Science 2025-10-29 Jinsol Song , Jiamu Wang , Anh Tien Nguyen , Keunho Byeon , Sangjeong Ahn , Sung Hak Lee , Jin Tae Kwak

Annotating bounding boxes is costly and limits the scalability of object detection. This challenge is compounded by the need to preserve high accuracy while minimizing manual effort in real-world applications. Prior active learning methods…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Rashi Sharma , Justin Timothy C. Bersamin , Karthikk Subramanian

Exploiting available medical records to train high performance computer-aided diagnosis (CAD) models via the semi-supervised learning (SSL) setting is emerging to tackle the prohibitively high labor costs involved in large-scale medical…

Computer Vision and Pattern Recognition · Computer Science 2021-02-17 Yirui Wang , Kang Zheng , Chi-Tung Chang , Xiao-Yun Zhou , Zhilin Zheng , Lingyun Huang , Jing Xiao , Le Lu , Chien-Hung Liao , Shun Miao