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Introduction: Clinical text classification using natural language processing (NLP) models requires adequate training data to achieve optimal performance. For that, 200-500 documents are typically annotated. The number is constrained by time…

Computation and Language · Computer Science 2026-01-23 Jaya Chaturvedi , Saniya Deshpande , Chenkai Ma , Robert Cobb , Angus Roberts , Robert Stewart , Daniel Stahl , Diana Shamsutdinova

Recent advances in large language models have led to renewed interest in natural language processing in healthcare using the free text of clinical notes. One distinguishing characteristic of clinical notes is their long time span over…

Computation and Language · Computer Science 2023-07-17 Hongyi Zheng , Yixin Zhu , Lavender Yao Jiang , Kyunghyun Cho , Eric Karl Oermann

In the United States, 25% or greater than 200 billion dollars of hospital spending accounts for administrative costs that involve services for medical coding and billing. With the increasing number of patient records, manual assignment of…

Computation and Language · Computer Science 2020-03-18 A. K. Bhavani Singh , Mounika Guntu , Ananth Reddy Bhimireddy , Judy W. Gichoya , Saptarshi Purkayastha

The era of big data is coming, and evidence-based medicine is attracting increasing attention to improve decision making in medical practice via integrating evidence from well designed and conducted clinical research. Meta-analysis is a…

Methodology · Statistics 2016-10-05 Dehui Luo , Xiang Wan , Jiming Liu , Tiejun Tong

Background: Clinical prediction models are increasingly used to inform healthcare decisions, but determining the minimum sample size for their development remains a critical and unresolved challenge. Inadequate sample sizes can lead to…

Machine Learning · Computer Science 2026-03-02 Diana Shamsutdinova , Felix Zimmer , Oyebayo Ridwan Olaniran , Sarah Markham , Daniel Stahl , Gordon Forbes , Ewan Carr

Knowing exactly how many data points need to be labeled to achieve a certain model performance is a hugely beneficial step towards reducing the overall budgets for annotation. It pertains to both active learning and traditional data…

Computation and Language · Computer Science 2023-07-04 Ernie Chang , Muhammad Hassan Rashid , Pin-Jie Lin , Changsheng Zhao , Vera Demberg , Yangyang Shi , Vikas Chandra

Although recent advances in scaling large language models (LLMs) have resulted in improvements on many NLP tasks, it remains unclear whether these models trained primarily with general web text are the right tool in highly specialized,…

Large Language Models (LLMs) have fundamentally transformed approaches to Natural Language Processing (NLP) tasks across diverse domains. In healthcare, accurate and cost-efficient text classification is crucial, whether for clinical notes…

Computation and Language · Computer Science 2026-02-16 Hajar Sakai , Sarah S. Lam

Machine learning (ML) methods are being increasingly used across various domains of medicine research. However, despite advancements in the use of ML in medicine, clear and definitive guidelines for determining sample sizes in medical ML…

Methodology · Statistics 2025-03-11 Wan Nor Arifin , Najib Majdi Yaacob

A ubiquitous task in processing electronic medical data is the assignment of standardized codes representing diagnoses and/or procedures to free-text documents such as medical reports. This is a difficult natural language processing task…

When solving NLP tasks with limited labelled data, researchers typically either use a general large language model without further update, or use a small number of labelled samples to tune a specialised smaller model. In this work, we…

Computation and Language · Computer Science 2026-01-26 Branislav Pecher , Ivan Srba , Maria Bielikova

This study evaluates how well large language models (LLMs) can classify ICD-10 codes from hospital discharge summaries, a critical but error-prone task in healthcare. Using 1,500 summaries from the MIMIC-IV dataset and focusing on the 10…

Computation and Language · Computer Science 2025-07-08 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Coding diagnosis and procedures in medical records is a crucial process in the healthcare industry, which includes the creation of accurate billings, receiving reimbursements from payers, and creating standardized patient care records. In…

Computation and Language · Computer Science 2020-01-01 Siddhartha Nuthakki , Sunil Neela , Judy W. Gichoya , Saptarshi Purkayastha

The field of clinical natural language processing has been advanced significantly since the introduction of deep learning models. The self-supervised representation learning and the transfer learning paradigm became the methods of choice in…

Computation and Language · Computer Science 2020-04-27 Andrey Kormilitzin , Nemanja Vaci , Qiang Liu , Alejo Nevado-Holgado

Metabolic syndrome (MetS) is a medication condition characterized by abdominal obesity, insulin resistance, hypertension and hyperlipidemia. It increases the risk of majority of chronic diseases, including type 2 diabetes mellitus, and…

Artificial Intelligence · Computer Science 2025-05-14 Yichen Zhao , Yuhua Wang , Xi Cheng , Junhao Fang , Yang Yang

Accurate sample classification using transcriptomics data is crucial for advancing personalized medicine. Achieving this goal necessitates determining a suitable sample size that ensures adequate statistical power without undue resource…

Methodology · Statistics 2024-09-11 Yunhui Qi , Xinyi Wang , Li-Xuan Qin

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark…

Background: Determining sample sizes for metabolomic experiments is important but due to the complexity of these experiments, there are currently no standard methods for sample size estimation in metabolomics. Since pilot studies are rarely…

Clinical notes are unstructured text generated by clinicians during patient encounters. Clinical notes are usually accompanied by a set of metadata codes from the International Classification of Diseases(ICD). ICD code is an important code…

Artificial Intelligence · Computer Science 2021-11-12 Tak-Sung Heo , Yongmin Yoo , Yeongjoon Park , Byeong-Cheol Jo , Kyungsun Kim

Objective: Clinical trials are essential for advancing pharmaceutical interventions, but they face a bottleneck in selecting eligible participants. Although leveraging electronic health records (EHR) for recruitment has gained popularity,…

Computation and Language · Computer Science 2026-01-15 Mojdeh Rahmanian , Seyed Mostafa Fakhrahmad , Seyedeh Zahra Mousavi
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