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Improving health in the most disadvantaged populations requires reliable estimates of health and demographic indicators to inform policy and interventions. Low- and middle-income countries with the largest burden of disease and disability…

Methodology · Statistics 2025-11-21 Austin E Schumacher , Jon Wakefield

Spatial confounding poses a significant challenge in scientific studies involving spatial data, where unobserved spatial variables can influence both treatment and outcome, possibly leading to spurious associations. To address this problem,…

Machine Learning · Computer Science 2024-12-04 Mauricio Tec , Ana Trisovic , Michelle Audirac , Sophie Woodward , Jie Kate Hu , Naeem Khoshnevis , Francesca Dominici

In this paper, we present a new statistical approach to automatically identify cancer regions in pathological images. The proposed method is built from statistical theory in line with evidence-based medicine. The two core technologies are…

Computer Vision and Pattern Recognition · Computer Science 2024-10-03 Toshiki Kindo

Increasing rates of global trade and travel, as well as changing climatic patterns, have led to more frequent outbreaks of plant disease epidemics worldwide. Mathematical modelling is a key tool in predicting where and how these new threats…

Populations and Evolution · Quantitative Biology 2019-11-28 Frédéric Fabre , Jérôme Coville , Nik J. Cunniffe

We intend to identify relationships between cancer cases and pollutant emissions and attempt to understand whether cancer in children is typically located together with some specific chemical combinations or is independent. Co-location…

An important task in drug development is to identify patients, which respond better or worse to an experimental treatment. Identifying predictive covariates, which influence the treatment effect and can be used to define subgroups of…

Methodology · Statistics 2018-11-27 Marius Thomas , Björn Bornkamp , Katja Ickstadt

Boundary discontinuity designs are used to learn about causal treatment effects along a continuous assignment boundary that splits units into control and treatment groups according to a bivariate location score. We analyze location-based…

Econometrics · Economics 2026-05-15 Matias D. Cattaneo , Rocio Titiunik , Ruiqi Rae Yu

Environmental epidemiologists are increasingly interested in establishing causality between exposures and health outcomes. A popular model for causal inference is the Rubin Causal Model (RCM), which typically seeks to estimate the average…

Applications · Statistics 2021-01-26 Keith W. Zirkle , Marie-Abele Bind , Jenise L. Swall , David C. Wheeler

We introduce a method called neighbor-based bootstrapping (NB2) that can be used to quantify the geospatial variation of a variable. We applied this method to an analysis of the incidence rates of disease from electronic medical record data…

Methodology · Statistics 2017-03-07 Maria T Patterson , Robert L Grossman

Multimorbidity, the co-occurrence of two or more chronic diseases such as diabetes, obesity or cardiovascular diseases in one patient, is a frequent phenomenon. To make care more efficient, it is of relevance to understand how different…

Medical Physics · Physics 2019-08-05 Nils Haug , Stefan Thurner , Alexandra Kautzky-Willer , Michael Gyimesi , Peter Klimek

Epidemic outbreaks are an important healthcare challenge, especially in developing countries where they represent one of the major causes of mortality. Approaches that can rapidly target subpopulations for surveillance and control are…

Social and Information Networks · Computer Science 2018-07-04 Stefania Rubrichi , Zbigniew Smoreda , Mirco Musolesi

Difference-in-differences is one of the most used identification strategies in empirical work in economics. This chapter reviews a number of important, recent developments related to difference-in-differences. First, this chapter reviews…

Econometrics · Economics 2022-08-02 Brantly Callaway

The identification and localization of diseases in medical images using deep learning models have recently attracted significant interest. Existing methods only consider training the networks with each image independently and most leverage…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 Cheng Zhang , Francine Chen , Yan-Ying Chen

Heterogeneity is a hallmark of complex diseases. Regression-based heterogeneity analysis, which is directly concerned with outcome-feature relationships, has led to a deeper understanding of disease biology. Such an analysis identifies the…

Methodology · Statistics 2022-11-29 Ziye Luo , Xinyue Yao , Yifan Sun , Xinyan Fan

Individuals do not respond uniformly to treatments, events, or interventions. Sociologists routinely partition samples into subgroups to explore how the effects of treatments vary by covariates like race, gender, and socioeconomic status.…

Other Statistics · Statistics 2019-09-23 Jennie E. Brand , Jiahui Xu , Bernard Koch , Pablo Geraldo

Rapid and accurate estimation of post-earthquake ground failures and building damage is critical for effective post-disaster responses. Progression in remote sensing technologies has paved the way for rapid acquisition of detailed,…

Geophysics · Physics 2024-12-03 Xuechun Li , Susu Xu

The need for more usable and explainable machine learning models in healthcare increases the importance of developing and utilizing causal discovery algorithms, which aim to discover causal relations by analyzing observational data.…

Machine Learning · Computer Science 2023-05-31 Mugariya Farooq , Shahad Hardan , Aigerim Zhumbhayeva , Yujia Zheng , Preslav Nakov , Kun Zhang

The analysis of population-wide datasets can provide insight on the health status of large populations so that public health officials can make data-driven decisions. The analysis of such datasets often requires highly parameterized models…

Applications · Statistics 2021-02-03 Dorota Młynarczyk , Carmen Armero , Virgilio Gómez-Rubio , Pedro Puig

Uncertainty maps highlight unreliable regions in segmentation predictions. However, most uncertainty evaluation metrics treat voxels independently, ignoring spatial context and anatomical structure. As a result, they may assign identical…

Computer Vision and Pattern Recognition · Computer Science 2025-06-23 Tal Zeevi , Eléonore V. Lieffrig , Lawrence H. Staib , John A. Onofrey

Joinpoint regression is used to determine the number of segments needed to adequately explain the relationship between two variables. This methodology can be widely applied to real problems, but we focus on epidemiological data, the main…

Applications · Statistics 2011-12-08 Miguel A. Martinez-Beneito , Gonzalo García-Donato , Diego Salmerón