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Drug repurposing has attracted increasing attention from both the pharmaceutical industry and the research community. Many existing computational drug repurposing methods rely on preclinical data (e.g., chemical structures, drug targets),…

Quantitative Methods · Quantitative Biology 2020-07-28 Qianlong Wen , Ruoqi Liu , Ping Zhang

Objectives: Our research adopts computational techniques to analyze disease outbreaks weekly over a large geographic area while maintaining local-level analysis by incorporating relevant high-spatial resolution cultural and environmental…

Machine Learning · Computer Science 2024-11-12 Scott Pezanowski , Etien Luc Koua , Joseph C Okeibunor , Abdou Salam Gueye

Disease mapping focuses on learning about areal units presenting high relative risk. Disease mapping models for disease counts specify Poisson regressions in relative risks compared with the expected counts. These models typically…

Methodology · Statistics 2016-07-26 Feifei Wang , Jian Wang , Alan E. Gelfand , Fan Li

Spatial correlation in areal unit count data is typically modelled by a set of random effects that are assigned a conditional autoregressive (CAR) prior distribution. The spatial correlation structure implied by this model depends on a…

Methodology · Statistics 2020-10-22 Duncan Lee , Kitty Meeks

Anomaly detection in random fields is an important problem in many applications including the detection of cancerous cells in medicine, obstacles in autonomous driving and cracks in the construction material of buildings. Such anomalies are…

Statistics Theory · Mathematics 2023-11-17 Claudia Kirch , Philipp Klein , Marco Meyer

Human mortality is in part a function of multiple socioeconomic factors that differ both spatially and temporally. Adjusting for other covariates, the human lifespan is positively associated with household wealth. However, the extent to…

Evidence synthesis models combine multiple data sources to estimate latent quantities of interest, enabling reliable inference on parameters that are difficult to measure directly. However, shared parameters across data sources can induce…

Methodology · Statistics 2025-11-06 Fuming Yang , David J. Nott , Anne M. Presanis

The scientific rigor and computational methods of causal inference have had great impacts on many disciplines, but have only recently begun to take hold in spatial applications. Spatial casual inference poses analytic challenges due to…

Methodology · Statistics 2020-07-07 Brian J Reich , Shu Yang , Yawen Guan , Andrew B Giffin , Matthew J Miller , Ana G Rappold

Healthcare professionals have long envisioned using the enormous processing powers of computers to discover new facts and medical knowledge locked inside electronic health records. These vast medical archives contain time-resolved…

Machine Learning · Computer Science 2020-05-15 Ahmed Allam , Matthias Dittberner , Anna Sintsova , Dominique Brodbeck , Michael Krauthammer

Neural networks are capable of learning rich, nonlinear feature representations shown to be beneficial in many predictive tasks. In this work, we use such models to explore different geographical feature representations in the context of…

Machine Learning · Computer Science 2018-09-11 Michael T. Lash , Min Zhang , Xun Zhou , W. Nick Street , Charles F. Lynch

Mixed data refers to a type of data in which variables can be of multiple types, such as continuous, discrete, or categorical. This data is routinely collected in various fields, including healthcare and social sciences. A common goal in…

Methodology · Statistics 2025-05-22 Mauro Florez , Anna Gottard , Carrie McAdams , Michele Guindani , Marina Vannucci

In clinical practice, regions of interest in medical imaging often need to be identified through a process of precise image segmentation. The quality of this image segmentation step critically affects the subsequent clinical assessment of…

Image and Video Processing · Electrical Eng. & Systems 2021-03-23 João B. S. Carvalho , João A. Santinha , Đorđe Miladinović , Joachim M. Buhmann

The recent availability of routine medical data, especially in a university-clinical context, may enable the discovery of typical healthcare pathways, i.e., typical temporal sequences of clinical interventions or hospital readmissions.…

Methodology · Statistics 2021-09-22 Nadine Binder , Kathrin Möllenhoff , August Sigle , Holger Dette

A causal decomposition analysis allows researchers to determine whether the difference in a health outcome between two groups can be attributed to a difference in each group's distribution of one or more modifiable mediator variables. With…

Methodology · Statistics 2024-08-09 Melissa J. Smith , Leslie A. McClure , D. Leann Long

Radiologists use time series of medical images to monitor the progression of a patient condition. They compare information gleaned from sequences of images to gain insight on progression or remission of the lesions, thus evaluating the…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 John Wandeto , Henry Nyongesa , Yves Remond , Birgitta Dresp-Langley

Most epidemic models are spatially aggregate and the index which is most used for planning and policy numbers, the r number, typically refers to a single system of interest. Even if r numbers are calculated for each of adjacent areas,…

Physics and Society · Physics 2020-05-18 Alan Wilson

Surveillance data serving for epidemic alert systems are typically fully aggregated in space. However, epidemics may be spatially heterogeneous, undergoing distinct dynamics in distinct regions of the surveillance area. We unveil this in…

Populations and Evolution · Quantitative Biology 2018-03-30 Pavel Polyakov , Cécile Souty , Pierre-Yves Böelle , Romulus Breban

To study the impact of climate variables on morbidity of some diseases in Mexico, we propose a spatio-temporal varying coefficients regression model. For that we introduce a new spatio-temporal dependent process prior, in a Bayesian…

Applications · Statistics 2019-12-02 Luis E. Nieto-Barajas

Infectious disease models can be of great use for understanding the underlying mechanisms that influence the spread of diseases and predicting future disease progression. Modeling has been increasingly used to evaluate the potential impact…

Applications · Statistics 2019-08-20 Md Mahsin , Rob Deardon , Patrick Brown

Bidirectional causal relationships arising from mutual interactions between variables are commonly observed within biomedical, econometrical, and social science contexts. When such relationships are further complicated by unobserved…

Methodology · Statistics 2026-01-27 Yafang Deng , Kang Shuai , Shanshan Luo
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