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Variational quantum algorithms (VQAs) constitute a prominent framework for exploring the capabilities of near-term quantum computers. As the effectiveness of VQAs depends heavily on the design of variational quantum circuits, Quantum…

Quantum Physics · Physics 2026-04-30 Haozhen Situ , Zhimin He , Lvzhou Li

Quadratic Unconstrained Binary Optimization (QUBO) is a broad class of optimization problems with many practical applications. To solve its hard instances in an exact way, known classical algorithms require exponential time and several…

Quantum Physics · Physics 2021-01-21 Gian Giacomo Guerreschi

Unsupervised representation learning presents new opportunities for advancing Quantum Architecture Search (QAS) on Noisy Intermediate-Scale Quantum (NISQ) devices. QAS is designed to optimize quantum circuits for Variational Quantum…

Quantum Physics · Physics 2026-02-04 Yize Sun , Zixin Wu , Volker Tresp , Yunpu Ma

Machine learning has emerged as a promising approach to study the properties of many-body systems. Recently proposed as a tool to classify phases of matter, the approach relies on classical simulation methods$-$such as Monte Carlo$-$which…

Quantum Physics · Physics 2020-07-17 Alexey Uvarov , Andrey Kardashin , Jacob Biamonte

Reinforcement learning has driven impressive advances in machine learning. Simultaneously, quantum-enhanced machine learning algorithms using quantum annealing underlie heavy developments. Recently, a multi-agent reinforcement learning…

Artificial Intelligence · Computer Science 2021-11-23 Tobias Müller , Christoph Roch , Kyrill Schmid , Philipp Altmann

The recent advent of commercially available quantum annealing hardware (QAH) has expanded opportunities for research into quantum annealing-based algorithms. In the domain of power systems, this advancement has driven increased interest in…

Optimization and Control · Mathematics 2025-03-26 Rosemary Barrass , Harsha Nagarajan , Carleton Coffrin

Demonstrating quantum advantage using conventional quantum algorithms remains challenging on current noisy gate-based quantum computers. Automated quantum circuit synthesis via quantum machine learning has emerged as a promising solution,…

Quantum Physics · Physics 2025-04-14 Shubing Xie , Aritra Sarkar , Sebastian Feld

Quantum annealers are specialized quantum computers for solving combinatorial optimization problems using special characteristics of quantum computing (QC), such as superposition, entanglement, and quantum tunneling. Theoretically, quantum…

Software Engineering · Computer Science 2024-07-29 Xinyi Wang , Asmar Muqeet , Tao Yue , Shaukat Ali , Paolo Arcaini

One of the most promising applications of quantum computing is simulating quantum many-body systems. However, there is still a need for methods to efficiently investigate these systems in a native way, capturing their full complexity. Here,…

Quantum Physics · Physics 2022-01-07 Korbinian Kottmann , Friederike Metz , Joana Fraxanet , Niccolo Baldelli

The development of tailored materials for specific applications is an active field of research in chemistry, material science and drug discovery. The number of possible molecules that can be obtained from a set of atomic species grow…

Quantum computing promises to solve previously intractable problems, with neutral atoms emerging as a promising technology. Zoned neutral atom architectures allow for immense parallelism and higher coherence times by shielding idling atoms…

Quantum Physics · Physics 2026-01-15 Yannick Stade , Wan-Hsuan Lin , Jason Cong , Robert Wille

We present a computational platform for modeling chemical reactions in complex molecular environments, focused on ligand-protein binding in drug discovery. The platform implements our new quantum-in-quantum-in-classical (QM/QM/MM)…

Multi-agent systems (MAS) utilizing multiple Large Language Model agents with Retrieval Augmented Generation and that can execute code locally may become beneficial in cosmological data analysis. Here, we illustrate a first small step…

Instrumentation and Methods for Astrophysics · Physics 2024-12-04 Andrew Laverick , Kristen Surrao , Inigo Zubeldia , Boris Bolliet , Miles Cranmer , Antony Lewis , Blake Sherwin , Julien Lesgourgues

This paper explores the applications of quantum annealing (QA) and classical simulated annealing (SA) to a suite of combinatorial optimization problems in machine learning, namely feature selection, instance selection, and clustering. We…

Quantum Physics · Physics 2025-07-22 Chloe Pomeroy , Aleksandar Pramov , Karishma Thakrar , Lakshmi Yendapalli

Quantum annealers provide an effective framework for solving large-scale combinatorial optimization problems. This work presents a novel methodology for training Variational Quantum Algorithms (VQAs) by reformulating the parameter…

Quantum Physics · Physics 2025-09-03 Ernesto Acosta , Guillermo Botella , Carlos Cano

We study quantum anomaly detection with density estimation and multivariate Gaussian distribution. Both algorithms are constructed using the standard gate-based model of quantum computing. Compared with the corresponding classical…

Quantum Physics · Physics 2019-06-26 Jin-Ming Liang , Shu-Qian Shen , Ming Li , Lei Li

Precision medicine has become a central focus in breast cancer management, advancing beyond conventional methods to deliver more precise and individualized therapies. Traditionally, histopathology images have been used primarily for…

Quantitative Methods · Quantitative Biology 2024-12-17 Suchithra Kunhoth , Somaya Al- Maadeed , Younes Akbari , Rafif Al Saady

The advent of quantum computing has opened new possibilities in data science, offering unique capabilities for addressing complex, data-intensive problems. Traditional machine learning algorithms often face challenges in high-dimensional or…

Quantum Physics · Physics 2025-02-13 Sanjeev Naguleswaran

This paper investigates the utilization of Quantum Computing and Neuromorphic Computing for Safe, Reliable, and Explainable Multi_Agent Reinforcement Learning (MARL) in the context of optimal control in autonomous robotics. The objective…

Emerging Technologies · Computer Science 2025-07-18 Mazyar Taghavi , Rahman Farnoosh

Optimizing the mRNA codon has an essential impact on gene expression for a specific target protein. It is an NP-hard problem; thus, exact solutions to such optimization problems become computationally intractable for realistic problem sizes…

Quantum Physics · Physics 2024-05-13 Hongfeng Zhang , Aritra Sarkar , Koen Bertels
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