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The steady progress of quantum hardware is motivating the search for novel quantum algorithm optimization strategies for near-term, real-world applications. In this study, we propose a novel feature map optimization strategy for Quantum…

Quantum Physics · Physics 2025-03-31 Roberto Moretti , Andrea Giachero , Voica Radescu , Michele Grossi

We propose two quantum algorithms for a problem in bioinformatics, position weight matrix (PWM) matching, which aims to find segments (sequence motifs) in a biological sequence such as DNA and protein that have high scores defined by the…

Quantum Physics · Physics 2023-03-08 Koichi Miyamoto , Naoki Yamamoto , Yasubumi Sakakibara

Quantum computing (QC) is expected to solve incredibly difficult problems, including finding optimal solutions to combinatorial optimization problems. However, to date, QC alone is still far to demonstrate this capability except on…

Emerging Technologies · Computer Science 2025-12-19 James B. Holliday , Eneko Osaba , Khoa Luu

Biomarker discovery is vital in advancing personalized medicine, offering insights into disease diagnosis, prognosis, and therapeutic efficacy. Traditionally, the identification and validation of biomarkers heavily depend on extensive…

Machine Learning · Computer Science 2024-09-25 Wangyang Ying , Dongjie Wang , Xuanming Hu , Ji Qiu , Jin Park , Yanjie Fu

Variational quantum algorithms (VQAs) are expected to be a path to quantum advantages on noisy intermediate-scale quantum devices. However, both empirical and theoretical results exhibit that the deployed ansatz heavily affects the…

Quantum Physics · Physics 2022-05-31 Yuxuan Du , Tao Huang , Shan You , Min-Hsiu Hsieh , Dacheng Tao

Detecting communities from complex networks has recently triggered great interest. Aiming at this problem, a new ant colony optimization strategy building on the Markov random walks theory, which is named as MACO, is proposed in this paper.…

Social and Information Networks · Computer Science 2013-03-26 Di Jin , Dayou Liu , Bo Yang , Jie Liu , Dongxiao He

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited…

Robotics · Computer Science 2025-07-03 Yibo Qiu , Zan Huang , Zhiyu Wang , Handi Liu , Yiling Qiao , Yifeng Hu , Shu'ang Sun , Hangke Peng , Ronald X Xu , Mingzhai Sun

Diagnosing the minimal set of faults capable of explaining a set of given observations, e.g., from sensor readouts, is a hard combinatorial optimization problem usually tackled with artificial intelligence techniques. We present the mapping…

In this pioneering research paper, we present a groundbreaking exploration into the synergistic fusion of classical and quantum computing paradigms within the realm of Generative Adversarial Networks (GANs). Our objective is to seamlessly…

Quantum Physics · Physics 2023-12-29 Sahil Nokhwal , Suman Nokhwal , Saurabh Pahune , Ankit Chaudhary

Quantum computing is gaining popularity across a wide range of scientific disciplines due to its potential to solve long-standing computational problems that are considered intractable with classical computers. One promising area where…

Quantum Physics · Physics 2023-05-15 Benjamin C. B. Symons , David Galvin , Emre Sahin , Vassil Alexandrov , Stefano Mensa

Drug discovery is lengthy and expensive, with traditional computer-aided design facing limits. This paper examines integrating quantum computing across the drug development cycle to accelerate and enhance workflows and rigorous…

Navigating the vast chemical space of molecular structures to design novel drug molecules with desired target properties remains a central challenge in drug discovery. Recent advances in generative models offer promising solutions. This…

Quantum processors may enhance machine learning by mapping high-dimensional data onto quantum systems for processing. Conventional feature maps, for encoding data onto a quantum circuit are currently impractical, as the number of entangling…

Quantum Physics · Physics 2026-03-27 Utkarsh Singh , Jean-Frédéric Laprade , Aaron Z. Goldberg , Khabat Heshami

Longitudinal biomedical studies play a vital role in tracking disease progression, treatment response, and the emergence of resistance mechanisms, particularly in complex disorders such as cancer and neurodegenerative diseases. However, the…

Quantitative Methods · Quantitative Biology 2025-04-28 Maria Demidik , Filippo Utro , Alexey Galda , Karl Jansen , Daniel Blankenberg , Laxmi Parida

Quantum counting is a key quantum algorithm that aims to determine the number of marked elements in a database. This algorithm is based on the quantum phase estimation algorithm and uses the evolution operator of Grover's algorithm because…

Quantum Physics · Physics 2023-12-11 Gustavo A. Bezerra , Raqueline A. M. Santos , Renato Portugal

Identification of cancer driver genes is fundamental for the development of targeted therapeutic interventions. The integration of mutational profiles with protein-protein interaction (PPI) networks offers a promising avenue for their…

Quantum Physics · Physics 2025-11-05 Patricia Marques , Andreas Wichert , Duarte Magano , Bruno Coutinho

Quantum computing promises to solve difficult optimization problems in chemistry, physics and mathematics more efficiently than classical computers, but requires fault-tolerant quantum computers with millions of qubits. To overcome errors…

Databases · Computer Science 2021-07-23 Tobias Fankhauser , Marc E. Solèr , Rudolf M. Füchslin , Kurt Stockinger

Machine learning has been increasingly utilized in the field of biomedical research to accelerate the drug discovery process. In recent years, the emergence of quantum computing has been followed by extensive exploration of quantum machine…

Quantum computing offers an alternative paradigm for addressing combinatorial optimization problems compared to classical computing. Despite recent hardware improvements, the execution of empirical quantum optimization experiments at scales…

DNA microarray technology enables the simultaneous measurement of expression levels of thousands of genes, thereby facilitating the understanding of the molecular mechanisms underlying complex diseases such as brain tumors and the…

Machine Learning · Computer Science 2025-08-29 Emine Akpinar , Batuhan Hangun , Murat Oduncuoglu , Oguz Altun , Onder Eyecioglu , Zeynel Yalcin
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