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To infer the treatment effect for a single treated unit using panel data, synthetic control methods construct a linear combination of control units' outcomes that mimics the treated unit's pre-treatment outcome trajectory. This linear…

Methodology · Statistics 2024-05-07 Hongxiang Qiu , Xu Shi , Wang Miao , Edgar Dobriban , Eric Tchetgen Tchetgen

To estimate the causal effect of an intervention, researchers need to identify a control group that represents what might have happened to the treatment group in the absence of that intervention. This is challenging without a randomized…

Methodology · Statistics 2026-03-20 Robert Pickett , Jennifer Hill , Sarah Cowan

The Synthetic Control method has pioneered a class of powerful data-driven techniques to estimate the counterfactual reality of a unit from donor units. At its core, the technique involves a linear model fitted on the pre-intervention…

Artificial Intelligence · Computer Science 2022-11-28 Bhishma Dedhia , Roshini Balasubramanian , Niraj K. Jha

Staggered adoption of policies by different units at different times creates promising opportunities for observational causal inference. Estimation remains challenging, however, and common regression methods can give misleading results. A…

Methodology · Statistics 2021-01-19 Eli Ben-Michael , Avi Feller , Jesse Rothstein

Neuroimaging consortia can enhance reliability and generalizability of findings by pooling data across studies to achieve larger sample sizes. To adjust for site and MRI protocol effects, imaging datasets are often harmonized based on…

Quantitative Methods · Quantitative Biology 2024-03-04 Shruti P. Gadewar , Alyssa H. Zhu , Iyad Ba Gari , Sunanda Somu , Sophia I. Thomopoulos , Paul M. Thompson , Talia M. Nir , Neda Jahanshad

The synthetic control method estimates the causal effect by comparing the treated unit's outcomes to a weighted average of control units that closely match its pre-treatment outcomes, assuming the relationship between treated and control…

Methodology · Statistics 2026-01-07 Taehyeon Koo , Zijian Guo

Randomized experiments are the gold standard for causal inference but face significant challenges in business applications, including limited traffic allocation, the need for heterogeneous treatment effect estimation, and the complexity of…

Methodology · Statistics 2025-08-18 Zhenkang Peng , Chengzhang Li , Ying Rong , Renyu Zhang

Synthetic control (SC) methods are commonly used to estimate the treatment effect on a single treated unit in panel data settings. An SC is a weighted average of control units built to match the treated unit, with weights typically…

Methodology · Statistics 2023-02-21 Xu Shi , Kendrick Li , Wang Miao , Mengtong Hu , Eric Tchetgen Tchetgen

A/B tests, also known as randomized controlled experiments (RCTs), are the gold standard for evaluating the impact of new policies, products, or decisions. However, these tests can be costly in terms of time and resources, potentially…

Machine Learning · Statistics 2025-01-03 Shima Nassiri , Mohsen Bayati , Joe Cooprider

Synthetic control methods are widely used to estimate the treatment effect on a single treated unit in time-series settings. A common approach to estimate synthetic control weights is to regress the treated unit's pre-treatment outcome and…

Methodology · Statistics 2025-03-06 Chan Park , Eric Tchetgen Tchetgen

Modern foundation models often undergo iterative ``bootstrapping'' in their post-training phase: a model generates synthetic data, an external verifier filters out low-quality samples, and the high-quality subset is used for further…

Machine Learning · Computer Science 2025-10-17 Pu Yang , Yunzhen Feng , Ziyuan Chen , Yuhang Wu , Zhuoyuan Li

Synthetic control (SC) methods have gained rapid popularity in economics recently, where they have been applied in the context of inferring the effects of treatments on standard continuous outcomes assuming linear input-output relations. In…

Methodology · Statistics 2024-02-19 Alicia Curth , Hoifung Poon , Aditya V. Nori , Javier González

We present a robust generalization of the synthetic control method for comparative case studies. Like the classical method, we present an algorithm to estimate the unobservable counterfactual of a treatment unit. A distinguishing feature of…

Econometrics · Economics 2017-11-21 Muhammad Jehangir Amjad , Devavrat Shah , Dennis Shen

This article extends the widely-used synthetic controls estimator for evaluating causal effects of policy changes to quantile functions. The proposed method provides a geometrically faithful estimate of the entire counterfactual quantile…

Econometrics · Economics 2022-01-03 Florian Gunsilius

Estimation and inference procedures for synthetic control methods often do not allow for the existence of spillover effects, which are plausible in many applications. In this paper, we consider estimation and inference for synthetic control…

Econometrics · Economics 2026-01-23 Jianfei Cao , Connor Dowd

We propose novel controller synthesis techniques for probabilistic systems modelled using stochastic two-player games: one player acts as a controller, the second represents its environment, and probability is used to capture uncertainty…

Logic in Computer Science · Computer Science 2017-01-11 Klaus Drager , Vojtech Forejt , Marta Kwiatkowska , David Parker , Mateusz Ujma

In recent years, epidemic policy-making models are increasingly being used to provide reference for governors on prevention and control policies against catastrophic epidemics such as SARS, H1N1 and COVID-19. Existing studies are currently…

Artificial Intelligence · Computer Science 2024-03-19 Zhiyi Tan , Bingkun Bao

This paper presents an automatic formal controller synthesis method for nonlinear sampled-data systems with safety and reachability specifications. Fundamentally, the presented method is not restricted to polynomial systems and controllers.…

Systems and Control · Computer Science 2018-12-07 Cees F. Verdier , Manuel Mazo

A significant challenge in wet lab experiments with current drug design generative models is the trade-off between pharmacological properties and synthesizability. Molecules predicted to have highly desirable properties are often difficult…

Machine Learning · Computer Science 2025-04-04 Songtao Liu , Dandan Zhang , Zhengkai Tu , Hanjun Dai , Peng Liu

The synthetic control method has become a widely popular tool to estimate causal effects with observational data. Despite this, inference for synthetic control methods remains challenging. Often, inferential results rely on linear factor…

Methodology · Statistics 2024-07-09 Ignacio Martinez , Jaume Vives-i-Bastida