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Missing data estimation is an important challenge with high-dimensional data arranged in the form of a matrix. Typically this data matrix is transposable, meaning that either the rows, columns or both can be treated as features. To model…

Applications · Statistics 2010-11-10 Genevera I. Allen , Robert Tibshirani

Recommending medications for patients using electronic health records (EHRs) is a crucial data mining task for an intelligent healthcare system. It can assist doctors in making clinical decisions more efficiently. However, the inherent…

Artificial Intelligence · Computer Science 2022-04-22 Yang An , Liang Zhang , Mao You , Xueqing Tian , Bo Jin , Xiaopeng Wei

Deep Learning (DL) methods have dramatically increased in popularity in recent years. While its initial success was demonstrated in the classification and manipulation of image data, there has been significant growth in the application of…

Machine Learning · Computer Science 2022-06-22 David K. Lim , Naim U. Rashid , Junier B. Oliva , Joseph G. Ibrahim

Missing data present challenges in data analysis. Naive analyses such as complete-case and available-case analysis may introduce bias and loss of efficiency, and produce unreliable results. Multiple imputation (MI) is one of the most widely…

Methodology · Statistics 2019-05-15 Domonique W. Hodge , Sandra E. Safo , Qi Long

Elastic Weight Consolidation (EWC) is a technique used in overcoming catastrophic forgetting between successive tasks trained on a neural network. We use this phenomenon of information sharing between tasks for domain adaptation. Training…

Computation and Language · Computer Science 2020-07-21 Avinash Madasu , Vijjini Anvesh Rao

Machine learning holds great promise for advancing the field of medicine, with electronic health records (EHRs) serving as a primary data source. However, EHRs are often sparse and contain missing data due to various challenges and…

Machine Learning · Computer Science 2026-02-25 Jun Han , Josue Nassar , Sanjit Singh Batra , Aldo Cordova-Palomera , Vijay Nori , Robert E. Tillman

Real-world Electronic Health Records (EHRs) are often plagued by a high rate of missing data. In our EHRs, for example, the missing rates can be as high as 90% for some features, with an average missing rate of around 70% across all…

Machine Learning · Computer Science 2022-07-12 Ge Gao , Farzaneh Khoshnevisan , Min Chi

Missing attribute values are quite common in the datasets available in the literature. Missing values are also possible because all attributes values may not be recorded and hence unavailable due to several practical reasons. For all these…

Information Retrieval · Computer Science 2016-05-04 Yelipe UshaRani , P. Sammulal

The challenge of missing data remains a significant obstacle across various scientific domains, necessitating the development of advanced imputation techniques that can effectively address complex missingness patterns. This study introduces…

Machine Learning · Computer Science 2025-01-22 Harsh Joshi , Rajeshwari Mistri , Manasi Mali , Nachiket Kapure , Parul Kumari

Deep learning has significantly advanced automatic medical diagnostics and released the occupation of human resources to reduce clinical pressure, yet the persistent challenge of data scarcity in this area hampers its further improvements…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Zehui Zhao , Laith Alzubaidi , Jinglan Zhang , Ye Duan , Usman Naseem , Yuantong Gu

Electronic health records (EHRs) linked with familial relationship data offer a unique opportunity to investigate the genetic architecture of complex phenotypes at scale. However, existing heritability and coheritability estimation methods…

Methodology · Statistics 2025-11-12 Yinjun Zhao , Nicholas Tatonetti , Yuanjia Wang

Healthcare is becoming a more and more important research topic recently. With the growing data in the healthcare domain, it offers a great opportunity for deep learning to improve the quality of medical service. However, the complexity of…

Computation and Language · Computer Science 2021-11-01 Bo Yang , Lijun Wu

Learning from Multi-Positive and Unlabeled (MPU) data has gradually attracted significant attention from practical applications. Unfortunately, the risk of MPU also suffer from the shift of minimum risk, particularly when the models are…

Machine Learning · Computer Science 2024-12-04 Zhongnian Li , Meng Wei , Peng Ying , Xinzheng Xu

Accuracy and interpretability are two dominant features of successful predictive models. Typically, a choice must be made in favor of complex black box models such as recurrent neural networks (RNN) for accuracy versus less accurate but…

Machine Learning · Computer Science 2017-02-28 Edward Choi , Mohammad Taha Bahadori , Joshua A. Kulas , Andy Schuetz , Walter F. Stewart , Jimeng Sun

Mortality prediction of diverse rare diseases using electronic health record (EHR) data is a crucial task for intelligent healthcare. However, data insufficiency and the clinical diversity of rare diseases make it hard for directly training…

Machine Learning · Computer Science 2020-05-12 Luchen Liu , Zequn Liu , Haoxian Wu , Zichang Wang , Jianhao Shen , Yiping Song , Ming Zhang

Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare…

Machine Learning · Computer Science 2018-10-24 Edward Choi , Cao Xiao , Walter F. Stewart , Jimeng Sun

With the increase of research in self-adaptive systems, there is a need to better understand the way research contributions are evaluated. Such insights will support researchers to better compare new findings when developing new knowledge…

Software Engineering · Computer Science 2021-03-23 Ilias Gerostathopoulos , Thomas Vogel , Danny Weyns , Patricia Lago

Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings.…

Adapting LLMs with new knowledge is increasingly important, but standard fine-tuning often erodes aligned epistemic abstention: the ability to acknowledge when the model does not know. This failure mode is especially concerning in…

Artificial Intelligence · Computer Science 2026-04-22 William F. Shen , Xinchi Qiu , Nicola Cancedda , Nicholas D. Lane

Identifying dependencies among variables in a complex system is an important problem in network science. Structural equation models (SEM) have been used widely in many fields for topology inference, because they are tractable and…

Signal Processing · Electrical Eng. & Systems 2020-03-20 Bakht Zaman , Luis Miguel Lopez Ramos , Baltasar Beferull-Lozano