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The surging availability of electronic medical records (EHR) leads to increased research interests in medical predictive modeling. Recently many deep learning based predicted models are also developed for EHR data and demonstrated…

Machine Learning · Computer Science 2018-02-15 Mengying Sun , Fengyi Tang , Jinfeng Yi , Fei Wang , Jiayu Zhou

Longitudinal electronic health record (EHR) data offer opportunities to study biomarker trajectories; however, association estimates-the primary inferential target-from standard models designed for regular observation times may be biased by…

Methodology · Statistics 2026-02-18 Cheng-Han Yang , Xu Shi , Bhramar Mukherjee

Missing value is a very common and unavoidable problem in sensors, and researchers have made numerous attempts for missing value imputation, particularly in deep learning models. However, for real sensor data, the specific data distribution…

Machine Learning · Computer Science 2022-09-27 JinSheng Yang , YuanHai Shao , ChunNa Li , Wensi Wang

Data imputation is an effective way to handle missing data, which is common in practical applications. In this study, we propose and test a novel data imputation process that achieve two important goals: (1) preserve the row-wise…

Machine Learning · Computer Science 2023-09-13 Katrina Chen , Xiuqin Liang , Zheng Ma , Zhibin Zhang

Clinical decision support using data mining techniques offers more intelligent way to reduce the decision error in the last few years. However, clinical datasets often suffer from high missingness, which adversely impacts the quality of…

Machine Learning · Computer Science 2020-11-20 Xuetong Wu , Hadi Akbarzadeh Khorshidi , Uwe Aickelin , Zobaida Edib , Michelle Peate

Sepsis remains one of the most complex and heterogeneous syndromes in intensive care, characterized by diverse physiological trajectories and variable responses to treatment. While deep learning models perform well in the early prediction…

Machine Learning · Computer Science 2026-04-01 Vincent Lemaire , Nédra Meloulli , Pierre Jaquet

Test-Time adaptation (TTA) aims to enhance model robustness against distribution shifts through rapid model adaptation during inference. While existing TTA methods often rely on entropy-based unsupervised training and achieve promising…

Computer Vision and Pattern Recognition · Computer Science 2025-05-08 Zixuan Hu , Yichun Hu , Ling-Yu Duan

Regularized linear discriminant analysis (RLDA) is a widely used tool for classification and dimensionality reduction, but its performance in high-dimensional scenarios is inconsistent. Existing theoretical analyses of RLDA often lack clear…

Machine Learning · Statistics 2025-07-23 Yonghan Zhang , Zhangni Pu , Lu Yan , Jiang Hu

Modeling patient disease progression using Electronic Health Records (EHRs) is critical to assist clinical decision making. While most of prior work has mainly focused on developing effective disease progression models using EHRs collected…

Machine Learning · Computer Science 2021-03-23 Farzaneh Khoshnevisan , Min Chi

The explosion in high-resolution data capture technologies in health has increased interest in making inferences about individual-level parameters. While technology may provide substantial data on a single individual, how best to use…

Methodology · Statistics 2021-12-16 Ziyu Ji , Julian Wolfson

The state-of-the-art performance on entity resolution (ER) has been achieved by deep learning. However, deep models are usually trained on large quantities of accurately labeled training data, and can not be easily tuned towards a target…

Machine Learning · Computer Science 2022-04-12 Zhaoqiang Chen , Qun Chen , Youcef Nafa , Tianyi Duan , Wei Pan , Lijun Zhang , Zhanhuai Li

Trial-based cost-effectiveness analyses (CEAs) are an important source of evidence in the assessment of health interventions. In these studies, cost and effectiveness outcomes are commonly measured at multiple time points, but some…

Methodology · Statistics 2022-03-30 Andrea Gabrio , Catrin Plumpton , Sube Banerjee , Baptiste Leurent

While the self-attention mechanism has been widely used in a wide variety of tasks, it has the unfortunate property of a quadratic cost with respect to the input length, which makes it difficult to deal with long inputs. In this paper, we…

Computation and Language · Computer Science 2020-09-30 Xiaoya Li , Yuxian Meng , Mingxin Zhou , Qinghong Han , Fei Wu , Jiwei Li

In healthcare, the integration of multimodal data is pivotal for developing comprehensive diagnostic and predictive models. However, managing missing data remains a significant challenge in real-world applications. We introduce MARIA…

Machine Learning · Computer Science 2026-03-13 Camillo Maria Caruso , Paolo Soda , Valerio Guarrasi

Although increasingly used as a data resource for assembling cohorts, electronic health records (EHRs) pose many analytic challenges. In particular, a patient's health status influences when and what data are recorded, generating sampling…

Methodology · Statistics 2020-04-28 Yifei Sun , Charles E. McCulloch , Kieren A. Marr , Chiung-Yu Huang

We present a boosting-based method to learn additive Structural Equation Models (SEMs) from observational data, with a focus on the theoretical aspects of determining the causal order among variables. We introduce a family of score…

Machine Learning · Statistics 2024-01-15 Maximilian Kertel , Nadja Klein

Linear Discriminant Analysis (LDA) is a well-known technique for feature extraction and dimension reduction. The performance of classical LDA, however, significantly degrades on the High Dimension Low Sample Size (HDLSS) data for the…

Machine Learning · Computer Science 2023-03-09 Sijia Yang , Haoyi Xiong , Kaibo Xu , Licheng Wang , Jiang Bian , Zeyi Sun

Electronic Health Records (EHRs), the digital representation of a patient's medical history, are a valuable resource for epidemiological and clinical research. They are also becoming increasingly complex, with recent trends indicating…

Machine Learning · Computer Science 2025-08-19 Rachael DeVries , Casper Christensen , Marie Lisandra Zepeda Mendoza , Ole Winther

This paper introduces SePA (Search-enhanced Predictive AI Agent), a novel LLM health coaching system that integrates personalized machine learning and retrieval-augmented generation to deliver adaptive, evidence-based guidance. SePA…

Human-Computer Interaction · Computer Science 2025-09-08 Melik Ozolcer , Sang Won Bae

We propose self-adaptive training---a new training algorithm that dynamically corrects problematic training labels by model predictions without incurring extra computational cost---to improve generalization of deep learning for potentially…

Machine Learning · Computer Science 2020-10-01 Lang Huang , Chao Zhang , Hongyang Zhang
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