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Non-contrast computed tomography calcium scoring (CTCS) is widely recognized as an effective tool for cardiovascular risk stratification. This study aimed to develop a novel machine learning framework for predicting myocardial ischemia from…

Machine Learning · Computer Science 2026-05-22 Juhwan Lee , Sadeer Al-Kindi , Ammar Hoori , Tao Hu , Hao Wu , Justin N. Kim , Robert Gilkeson , Sanjay Rajagopalan , David L. Wilson

Calcium scoring, a process in which arterial calcifications are detected and quantified in CT, is valuable in estimating the risk of cardiovascular disease events. Especially when used to quantify the extent of calcification in the coronary…

Image and Video Processing · Electrical Eng. & Systems 2021-05-27 Sanne G. M. van Velzen , Nils Hampe , Bob D. de Vos , Ivana Išgum

Coronary artery calcium (CAC) is highly predictive of cardiovascular events. While millions of chest CT scans are performed annually in the United States, CAC is not routinely quantified from scans done for non-cardiac purposes. A deep…

Despite coronary artery calcium scoring being considered a largely solved problem within the realm of medical artificial intelligence, this paper argues that significant improvements can still be made. By shifting the focus from pathology…

Non-contrast computed tomography calcium scoring (CTCS) is a cost-effective imaging modality widely used to detect coronary artery calcifications. This study aimed to develop an advanced machine learning framework that utilizes quantitative…

Coronary artery calcium (CAC) is a significant marker of atherosclerosis and cardiovascular events. In this work we present a system for the automatic quantification of calcium score in ECG-triggered non-contrast enhanced cardiac computed…

Computer Vision and Pattern Recognition · Computer Science 2017-10-10 G. Santini , D. Della Latta , N. Martini , G. Valvano , A. Gori , A. Ripoli , C. L. Susini , L. Landini , D. Chiappino

Background: Recent studies have used basic epicardial adipose tissue (EAT) assessments (e.g., volume and mean HU) to predict risk of atherosclerosis-related, major adverse cardiovascular events (MACE). Objectives: Create novel, hand-crafted…

Quantitative Methods · Quantitative Biology 2024-01-31 Tao Hu , Joshua Freeze , Prerna Singh , Justin Kim , Yingnan Song , Hao Wu , Juhwan Lee , Sadeer Al-Kindi , Sanjay Rajagopalan , David L. Wilson , Ammar Hoori

Aims. To develop a deep-learning based system for recognition of subclinical atherosclerosis on a plain frontal chest x-ray. Methods and Results. A deep-learning algorithm to predict coronary artery calcium (CAC) score (the AI-CAC model)…

Coronary artery calcium (CAC) scoring is a key predictor of cardiovascular risk, but it relies on ECG-gated CT scans, restricting its use to specialized cardiac imaging settings. We introduce an automated framework for CAC detection and…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Mahmut S. Gokmen , Moneera N. Haque , Steve W. Leung , Caroline N. Leach , Seth Parker , Stephen B. Hobbs , Vincent L. Sorrell , W. Brent Seales , V. K. Cody Bumgardner

Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into…

Computer Vision and Pattern Recognition · Computer Science 2024-01-18 Mehdi Ramezanpour , Anne M. Robertson , Yasutaka Tobe , Xiaowei Jia , Juan R. Cebral

Cardiovascular disease causes high rates of mortality worldwide. Coronary artery calcium (CAC) scoring is a powerful tool to stratify the risk of atherosclerotic cardiovascular disease. Current scoring practices require time-intensive…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Lachlan Nguyen , Aidan Cousins , Arcot Sowmya , Hugh Dixson , Sonit Singh

Purpose: Coronary artery calcium (CAC) score, i.e. the amount of CAC quantified in CT, is a strong and independent predictor of coronary heart disease (CHD) events. However, CAC scoring suffers from limited interscan reproducibility, which…

Image and Video Processing · Electrical Eng. & Systems 2022-06-13 Sanne G. M. van Velzen , Bob D. de Vos , Julia M. H. Noothout , Helena M. Verkooijen , Max A. Viergever , Ivana Išgum

CAD remains a major global public health burden, yet scalable screening tools are limited. Although CCTA is a first-line non-invasive diagnostic modality, its use is constrained by resource requirements and radiation exposure. AI-ECG may…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Yujie Xiao , Qinghao Zhao , Gongzheng Tang , Hao Zhang , Zhuoran Kan , Deyun Zhang , Jun Li , Guangkun Nie , Xiaocheng Fang , Haoyu Wang , Shun Huang , Tong Liu , Jian Liu , Kangyin Chen , Shenda Hong

Coronary artery calcium (CAC) scoring plays a crucial role in the early detection and risk stratification of coronary artery disease (CAD). In this study, we focus on non-contrast coronary computed tomography angiography (CCTA) scans, which…

Women are underdiagnosed and undertreated for cardiovascular disease. Automatic quantification of breast arterial calcification on screening mammography can identify women at risk for cardiovascular disease and enable earlier treatment and…

Every year, thousands of innocent people die due to heart attacks. Often undiagnosed heart attacks can hit people by surprise since many current medical plans don't cover the costs to require the searching of calcification on these scans.…

Image and Video Processing · Electrical Eng. & Systems 2022-09-23 Sanskriti Singh

Coronary artery calcification (CAC) is a strong predictor of cardiovascular risk but remains underutilized in clinical routine thoracic imaging due to the need for dedicated imaging protocols and manual annotation. We present DeepCAC2, a…

Image and Video Processing · Electrical Eng. & Systems 2026-03-27 Leonard Nürnberg , Simon Bernatz , Borek Foldyna , Michael T. Lu , Andrey Fedorov , Hugo JWL Aerts

We investigated the feasibility and advantages of using non-contrast CT calcium score (CTCS) images to assess pericoronary adipose tissue (PCAT) and its association with major adverse cardiovascular events (MACE). PCAT features from…

Computer Vision and Pattern Recognition · Computer Science 2024-01-30 Yingnan Song , Hao Wu , Juhwan Lee , Justin Kim , Ammar Hoori , Tao Hu , Vladislav Zimin , Mohamed Makhlouf , Sadeer Al-Kindi , Sanjay Rajagopalan , Chun-Ho Yun , Chung-Lieh Hung , David L. Wilson

Coronary artery calcium (CAC) burden quantified in low-dose chest CT is a predictor of cardiovascular events. We propose an automatic method for CAC quantification, circumventing intermediate segmentation of CAC. The method determines a…

Computer Vision and Pattern Recognition · Computer Science 2017-12-11 Bob D. de Vos , Nikolas Lessmann , Pim A. de Jong , Max A. Viergever , Ivana Isgum

Coronary artery calcium (CAC) is biomarker of advanced subclinical coronary artery disease and predicts myocardial infarction and death prior to age 60 years. The slice-wise manual delineation has been regarded as the gold standard of…

Computer Vision and Pattern Recognition · Computer Science 2018-11-13 Yuankai Huo , James G. Terry , Jiachen Wang , Vishwesh Nath , Camilo Bermudez , Shunxing Bao , Prasanna Parvathaneni , J. Jeffery Carr , Bennett A. Landman
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