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This paper presents libRoadRunner, an extensible, high-performance, cross-platform, open-source software library for the simulation and analysis of models \ expressed using Systems Biology Markup Language (SBML). SBML is the most widely…

Subcellular Processes · Quantitative Biology 2015-03-04 Endre T. Somogyi , Jean-Marie Bouteiller , James A. Glazier , Matthias König , Kyle Medley , Maciej H. Swat , Herbert M. Sauro

Large language model (LLM) serving infrastructures are undergoing a shift toward heterogeneity and disaggregation. Modern deployments increasingly integrate diverse accelerators and near-memory processing technologies, introducing…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-24 Jaehong Cho , Hyunmin Choi , Guseul Heo , Jongse Park

Neural networks have become indispensable for a wide range of applications, but they suffer from high computational- and memory-requirements, requiring optimizations from the algorithmic description of the network to the hardware…

Signal Processing · Electrical Eng. & Systems 2020-05-05 Andreas Toftegaard Kristensen , Robert Giterman , Alexios Balatsoukas-Stimming , Andreas Burg

The ability to dynamically allocate memory is fundamental in modern programming languages. However, this feature is not adequately supported in current general-purpose PIM devices. To identify key design principles that PIM must consider,…

Hardware Architecture · Computer Science 2026-01-28 Dongjae Lee , Bongjoon Hyun , Youngjin Kwon , Minsoo Rhu

Memory is fundamental to intelligence, enabling learning, reasoning, and adaptability across biological and artificial systems. While Transformer architectures excel at sequence modeling, they face critical limitations in long-range context…

Machine Learning · Computer Science 2025-08-19 Parsa Omidi , Xingshuai Huang , Axel Laborieux , Bahareh Nikpour , Tianyu Shi , Armaghan Eshaghi

Dynamic Random Access Memory (DRAM) is the de-facto choice for main memory devices due to its cost-effectiveness. It offers a larger capacity and higher bandwidth compared to SRAM but is slower than the latter. With each passing generation,…

Hardware Architecture · Computer Science 2022-01-19 Kaustav Goswami , Hemanta Kumar Mondal , Shirshendu Das , Dip Sankar Banerjee

Robust implementable output regulator design approaches are studied for general linear continuous-time \mbox{systems} with periodically sampled measurements, consisting of both the regulation errors and extra measurements that are generally…

Optimization and Control · Mathematics 2021-03-01 Lei Wang , Lorenzo Marconi , Christopher M. Kellett

Deeply embedded systems often have the tightest constraints on energy consumption, requiring that they consume tiny amounts of current and run on batteries for years. However, they typically execute code directly from flash, instead of the…

Other Computer Science · Computer Science 2021-04-13 James Pallister , Kerstin Eder , Simon Hollis

The emerging hybrid DRAM-NVM architecture is challenging the existing memory management mechanism in operating system. In this paper, we introduce memos, which can schedule memory resources over the entire memory hierarchy including cache,…

Operating Systems · Computer Science 2017-03-23 Lei Liu , Mengyao Xie , Hao Yang

This work introduces MICSim, an open-source, pre-circuit simulator designed for early-stage evaluation of chip-level software performance and hardware overhead of mixed-signal compute-in-memory (CIM) accelerators. MICSim features a modular…

Artificial Intelligence · Computer Science 2024-12-18 Cong Wang , Zeming Chen , Shanshi Huang

This paper summarizes the idea of Subarray-Level Parallelism (SALP) in DRAM, which was published in ISCA 2012, and examines the work's significance and future potential. Modern DRAMs have multiple banks to serve multiple memory requests in…

Hardware Architecture · Computer Science 2018-05-08 Yoongu Kim , Vivek Seshadri , Donghyuk Lee , Jamie Liu , Onur Mutlu

The design of the buffer manager in database management systems (DBMSs) is influenced by the performance characteristics of volatile memory (DRAM) and non-volatile storage (e.g., SSD). The key design assumptions have been that the data must…

Databases · Computer Science 2019-01-31 Joy Arulraj , Andy Pavlo , Krishna Teja Malladi

Mastering computational architectures is essential for developing fast and power-efficient programs. Our advanced simulator empowers both IT students and professionals to grasp the fundamentals of superscalar RISC-V processors, HW/SW…

Hardware Architecture · Computer Science 2024-11-13 Jiri Jaros , Michal Majer , Jakub Horky , Jan Vavra

Simulators perform an important role in prototyping, debugging, and benchmarking new advances in robotics and learning for control. Although many physics engines exist, some aspects of the real world are harder than others to simulate. One…

Robotics · Computer Science 2022-02-14 Shaoxiong Wang , Mike Lambeta , Po-Wei Chou , Roberto Calandra

Scaling up hardware systems has become an important tactic for improving performance as Moore's law fades. Unfortunately, simulations of large hardware systems are often a design bottleneck due to slow throughput and long build times. In…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-07-31 Steven Herbst , Noah Moroze , Edgar Iglesias , Andreas Olofsson

Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the…

Quantum Physics · Physics 2017-01-12 P. Pfeiffer , I. L. Egusquiza , M. Di Ventra , M. Sanz , E. Solano

Chemical modelling serves two purposes in dynamical models: accounting for the effect of microphysics on the dynamics and providing observable signatures. Ideally, the former must be done as part of the hydrodynamic simulation but this…

Computational Physics · Physics 2021-09-15 J. Holdship , S. Viti , T. J. Haworth , J. D. Ilee

With the imminent slowing down of DRAM scaling, Phase Change Memory (PCM) is emerging as a lead alternative for main memory technology. While PCM achieves low energy due to various technology-specific advantages, PCM is significantly slower…

Hardware Architecture · Computer Science 2015-04-17 Hamza Bin Sohail , Balajee Vamanan , T. N. Vijaykumar

Simulation has become an essential component of designing and developing scientific experiments. The conventional procedural approach to coding simulations of complex experiments is often error-prone, hard to interpret, and inflexible,…

Computational Physics · Physics 2023-08-09 Peter Sun , John A. Marohn

Transformers have reached remarkable success in sequence modeling. However, these models have efficiency issues as they need to store all the history token-level representations as memory. We present Memformer, an efficient neural network…

Computation and Language · Computer Science 2022-04-14 Qingyang Wu , Zhenzhong Lan , Kun Qian , Jing Gu , Alborz Geramifard , Zhou Yu
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